BPI Antikörper

Produktnummer ABIN1105557

Dieses Anti-BPI-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von BPI in IP und EIA. Geeignet für Human.

Kurzübersicht für BPI Antikörper (ABIN1105557)

Target: BPI (Bactericidal/Permeability Increasing Protein (BPI))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BPI Antikörper ist unkonjugiert

Applikation: Immunoprecipitation (IP), Enzyme Immunoassay (EIA)

Produktdetails anti-BPI Antikörper

Spezifität: The polyclonal antibody reacts specifically with full length human natural and recombinant Bactericidal Permeability Increasing protein (BPI). It recognizes only free BPI and does not interact with BPI that has formed a complex with LPS.

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Protein A

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2 - 8 °C.

Details zu BPI

Target: BPI (Bactericidal/Permeability Increasing Protein (BPI))

Andere Bezeichnung: BPI

Hintergrund: The antimicrobial protein BPI is a 55 kDa protein found in the primary (azurophilic) granules of human neutrophils and has also been detected on surface of neutrophils, small intestinal and oral epithelial cells. BPI is a bactericidal compound that is present in polymorphonuclear cells (PMN) and in lower levels in the specific granules of eosinophils. BPI possesses high affinity toward the lipid A region of lipopolysaccharides (LPS) that comprise the outer leaflet of the gram-negative bacterial outer membrane. Binding of BPI to the lipid A moiety of LPS exerts multiple anti-infective activities against gram-negative bacteria: 1) cytotoxicity via sequential damage to bacterial outer and inner lipid membranes, 2) neutralization of gram-negative bacterial LPS, 3) opsonization of bacteria to enhance phagocytosis by neutrophils. Airway epithelial cells constitutively express the BPI gene and produce the BPI protein and, therefore, BPI may be a critical determinant in the development of LPS-triggered airways disease. Inflammation induced by LPS possibly contributes to the development of rapid airflow decline, a serious and often fatal complication of hematopoietic cell transplantation. Furthermore, a 21 kDa bioactive recombinant fragment of BPI, rBPI21, was shown to confer a survival advantage against invasive pneumococcal disease by binding to the gram-positive bacterial pathogen, pneumolysin.Synonyms: Bactericidal permeability-increasing protein, CAP57

Gen-ID: 671

NCBI Accession: NP_001716

UniProt: P17213