Asialoglycoprotein Receptor 1 Antikörper

Produktnummer ABIN1105447

Dieses Maus Monoklonal-Antikörper erkennt spezifisch Asialoglycoprotein Receptor 1 in WB, IF, EIA und IHC (fro). Er zeigt eine Reaktivität gegenüber Human und Ratte.

Kurzübersicht für Asialoglycoprotein Receptor 1 Antikörper (ABIN1105447)

Target: Asialoglycoprotein Receptor 1 (ASGR1)

Reaktivität: Human, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Asialoglycoprotein Receptor 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: 8D7

Produktdetails anti-Asialoglycoprotein Receptor 1 Antikörper

Spezifität: This antibody recognizes a subunit-specific epitope on RHL-1 of rat ASGPR.

Kreuzreaktivität (Details): Species reactivity (tested):Human, rat

Aufreinigung: Protein G

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 1 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2 - 8 °C.

Details zu Asialoglycoprotein Receptor 1

Target: Asialoglycoprotein Receptor 1 (ASGR1)

Andere Bezeichnung: ASGR1

Hintergrund: The asialoglycoprotein (ASGP) receptor is a transmembrane hepatocellular surface carbohydrate binding glycoproteins lacking terminal sialic acid residues (asialoglycoproteins). Characterization of the ASGP receptor revealed its functional role in the binding, internalization and transport of a wide range of glycoproteins, which have exposed galactose or N-acetylgalactosamine residues, via the process of receptor-mediated endocytosis (RME). The ASGP receptor can bind a variety of important plasma proteins including transport proteins (i.e. transferrin), enzymes such as alkaline phosphatase, immunoglobulins including IgA, apoptotic hepatocytes, fibronectin and platelets. Additionally, the expression of the ASGP receptor has been clinically correlated to the level of hepatic function that is lost during liver diseases related to cancer, viral hepatitis, and cirrhosis. The ASGP receptor consists of major and minor subunits, which in the rat were identified as rat hepatic lectin (RHL) 1 and RHL 2/3, with molecular weights of respectively 42, 49 and 54 kDa. The selective binding (calcium and pH depended) and uptake of terminal galactosyl bearing proteins requires the formation of hetero-oligomers between these major and minor forms The total ASGP receptor population consisted of two functionally distinct receptor populations, designated State 1 and State 2, which were involved in the endocytosis and intracellular processing of ligands by different pathways.Synonyms: ASGP-R 1, ASGPR 1, Asialoglycoprotein receptor 1, Hepatic lectin H1

Gen-ID: 24210

NCBI Accession: NP_036635

UniProt: P02706

Pathways: Thyroid Hormone Synthesis