Prosaposin Antikörper (AA 325-524)

Produktnummer ABIN1098150

Dieses Anti-Prosaposin-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Prosaposin in IHC, ELISA, ICC und FACS. Geeignet für Human. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.

Kurzübersicht für Prosaposin Antikörper (AA 325-524) (ABIN1098150)

Target: Prosaposin (PSAP)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Prosaposin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Klon: 4D5F4

Produktdetails anti-Prosaposin Antikörper

Bindungsspezifität: AA 325-524

Verwendungszweck: PSAP Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human PSAP (AA: 325-524 ) expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/50 - 1/500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-Prosaposin Antikörper (ABIN1098150)

Xu, Deng, Mao, Zhang, Wang, Wang, Mu, Deng, Ma: "The interaction of the second Kunitz-type domain (KD2) of TFPI-2 with a novel interaction partner, prosaposin, mediates the inhibition of the invasion and migration of human fibrosarcoma cells." in: The Biochemical journal, Vol. 441, Issue 2, pp. 665-74, (2011) (PubMed).

Hu, Delorme, Liu, Liu, Velasco-Gonzalez, Garai, Pullikuth, Koochekpour: "Prosaposin down-modulation decreases metastatic prostate cancer cell adhesion, migration, and invasion." in: Molecular cancer, Vol. 9, pp. 30, (2010) (PubMed).

Details zu Prosaposin

Target: Prosaposin (PSAP)

Andere Bezeichnung: PSAP

Hintergrund: This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molekulargewicht: 58.1 kDa

UniProt: P07602

Pathways: Positive Regulation of Endopeptidase Activity