KEAP1 Antikörper (AA 380-624)

Produktnummer ABIN1098141

Dieses Anti-KEAP1-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von KEAP1 in ELISA, IHC und FACS. Geeignet für Human. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.

Kurzübersicht für KEAP1 Antikörper (AA 380-624) (ABIN1098141)

Target: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser KEAP1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Klon: 7G4B10

Produktdetails anti-KEAP1 Antikörper

Bindungsspezifität: AA 380-624

Verwendungszweck: KEAP1 Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human KEAP1 (AA: 380-624 ) expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-KEAP1 Antikörper (ABIN1098141)

Muscarella, Barbano, DAngelo, Copetti, Coco, Balsamo, la Torre, Notarangelo, Troiano, Parisi, Icolaro, Catapano, Valori, Pellegrini, Merla, Carella, Fazio, Parrella: "Regulation of KEAP1 expression by promoter methylation in malignant gliomas and association with patient's outcome." in: Epigenetics, Vol. 6, Issue 3, pp. 317-25, (2011) (PubMed).

Niture, Jaiswal: "INrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosis." in: Cell death and differentiation, Vol. 18, Issue 3, pp. 439-51, (2011) (PubMed).

Details zu KEAP1

Target: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Andere Bezeichnung: KEAP1

Hintergrund: This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.

Molekulargewicht: 69.7 kDa

Gen-ID: 9817

UniProt: Q14145

Pathways: Maintenance of Protein Location