KEAP1 Antikörper (AA 380-624)

Produktnummer ABIN1098137

Der Maus Monoklonal Anti-KEAP1-Antikörper wurde für ELISA, ICC und FACS validiert. Er ist geeignet, KEAP1 in Proben von Human und Maus zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für KEAP1 Antikörper (AA 380-624) (ABIN1098137)

Target: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser KEAP1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Klon: 1F10B6

Produktdetails anti-KEAP1 Antikörper

Bindungsspezifität: AA 380-624

Verwendungszweck: KEAP1 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human KEAP1 (AA: 380-624) expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-KEAP1 Antikörper (ABIN1098137)

Kim, You, Lee, Ahn, Seong, Hwang: "Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation." in: Cellular signalling, Vol. 22, Issue 11, pp. 1645-54, (2010) (PubMed).

Zhang, Singh, Yegnasubramanian, Esopi, Kombairaju, Bodas, Wu, Bova, Biswal: "Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth." in: Molecular cancer therapeutics, Vol. 9, Issue 2, pp. 336-46, (2010) (PubMed).

Details zu KEAP1

Target: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Andere Bezeichnung: KEAP1

Hintergrund: This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.

Molekulargewicht: 69.7 kDa

Gen-ID: 9817

UniProt: Q14145

Pathways: Maintenance of Protein Location