Interleukin 17F (IL17F) Antikörper (Biotin)

Details zu Produkt Nr. ABIN1043791, Anbieter: Anmelden zum Anzeigen
Antigen
  • FISP
  • Mda7
  • St16
  • Mda-7
  • IL17F
  • IL-17F
  • CANDF6
  • ML-1
  • ML1
  • C87042
  • interleukin 24
  • interleukin 17F
  • interleukin 17A
  • Il24
  • IL24
  • IL17F
  • IL17A
  • Il17f
Reaktivität
Human
213
73
29
1
Wirt
Maus
139
112
16
15
Klonalität (Klon)
Monoklonal ()
Konjugat
Biotin
30
13
13
12
11
10
9
7
7
6
6
6
4
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
178
110
88
47
29
13
10
9
7
6
6
4
4
4
4
3
3
2
2
2
1
1
1
1
1
1
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Immunogen Anti-IL-17F (MOUSE) Monoclonal Antibody was produced in mouse by repeated immunizations with mature full length recombinant human IL-17F produced in E.coli followed by hybridoma development.
Immunogen Type: RecombinantProtein
Klon 4H1629-1
Isotyp IgG1
Spezifität This product was purified from concentrated tissue culture supernate by Protein G chromatography followed by extensive dialysis against the buffer stated above. This antibody is specific for human IL-17F protein. A BLAST analysis was used to suggest cross-reactivity with IL-17F from human sources based on 100% homology with the immunizing sequence. Cross-reactivity with IL-17F from other sources has not been determined.
Produktmerkmale Anti-L-17F recognizes IL-17F (also known as Cytokine ML-1 or Interleukin-24). IL-17F is produced and secreted by CD8+ T cells, NK cells, NKT cells and LTi cells. The main functions of IL-17F are neutrophil recruitment and immunity to extracellular pathogen. More importantly, IL-17F drives inflammation and auto-immunity. IL-17A and IL-17F are by far the best characterized cytokines of the IL-17 cytokine family. IL-17F dimerizes in a parallel fashion similar to nerve growth factor and other neutrophins. Its dimerization is critical to fulfill its activity. When secreted by activated T cells, IL-17F can stimulate the production of other cytokines such as IL-6, IL-8 granulocyte colony-stimulating factor and, can stimulate cartilage matrix turnover. Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6). CANDF6 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. Anti-IL-17E cytokine antibody is ideal for investigators involved in Immunology, Signal Transduction research, Cancer and Inflammatory pathologies.
Reinigung purified
Andere Bezeichnung IL-17F (IL17F Antibody Abstract)
Hintergrund Anti-L-17F recognizes IL-17F (also known as Cytokine ML-1 or Interleukin-24). IL-17F is produced and secreted by CD8+ T cells, NK cells, NKT cells and LTi cells. The main functions of IL-17F are neutrophil recruitment and immunity to extracellular pathogen. More importantly, IL-17F drives inflammation and auto-immunity. IL-17A and IL-17F are by far the best characterized cytokines of the IL-17 cytokine family. IL-17F dimerizes in a parallel fashion similar to nerve growth factor and other neutrophins. Its dimerization is critical to fulfill its activity. When secreted by activated T cells, IL-17F can stimulate the production of other cytokines such as IL-6, IL-8 granulocyte colony-stimulating factor and, can stimulate cartilage matrix turnover. Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6). CANDF6 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. Anti-IL-17E cytokine antibody is ideal for investigators involved in Immunology, Signal Transduction research, Cancer and Inflammatory pathologies.
Synonyms: Interleukin-17F, Cytokine ML-1, Interleukin-24
Gen-ID 112744
NCBI Accession NP_443104
UniProt Q96PD4
Pathways Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity
Applikationshinweise This purified antibody has been tested for use in IHC and Western Blot. Specific conditions for reactivity should be optimized by the end user.
Kommentare

Gene Name: IL17F

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Rekonstitution Reconstitution Buffer: Restore with deionized water (or equivalent), Reconstitution Volume: 100 µL
Konzentration 1.0 mg/mL
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 10 mg/mL Bovine Serum Albumin (BSA) - Immunoglobulin and Protease free
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.
Haltbarkeit 12 months
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-Interleukin 17F (IL17F) antibody (Biotin) (ABIN1043791) Immunohistochemistry of Mouse Anti-IL-17F antibody Tissue: human colon tissue Fixatio...
 image for anti-Interleukin 17F (IL17F) antibody (Biotin) (ABIN1043791) anti-Interleukin 17F (IL17F) antibody (Biotin) (Image 2)
Western Blotting (WB) image for anti-Interleukin 17F (IL17F) antibody (Biotin) (ABIN1043791) Western Blot of Mouse Anti-IL-17F antibody Lane 1: human full length recombinant IL-1...
Immunohistochemistry (IHC) image for anti-Interleukin 17F (IL17F) antibody (Biotin) (ABIN1043791) Immunohistochemistry of Mouse Anti-IL-17F antibody Tissue: human colon tissue Fixatio...
Produkt verwendet in: Conti, Shen, Nayyar, Stocum, Sun, Lindemann, Ho, Hai, Yu, Jung, Filler, Masso-Welch, Edgerton, Gaffen: "Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis." in: The Journal of experimental medicine, Vol. 206, Issue 2, pp. 299-311, 2009 (PubMed).

Haben Sie etwas anderes gesucht?