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TIMP4 Antikörper

This anti-TIMP4 antibody (ABIN1043743) is a Mouse Monoclonal antibody detecting TIMP4 in WB, IHC, ELISA. Suitable for Human.
Rockland
Produktnummer ABIN1043743
Hersteller Produkt- Nr.: 200-301-e65

Quick Overview for TIMP4 Antikörper (ABIN1043743)

Target

Alle TIMP4 Antikörper anzeigen
TIMP4 (TIMP Metallopeptidase Inhibitor 4 (TIMP4))

Reaktivität

  • 70
  • 42
  • 35
  • 16
  • 13
  • 4
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 104
  • 13
  • 1
Maus

Klonalität

  • 105
  • 13
Monoklonal

Konjugat

  • 54
  • 19
  • 10
  • 5
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser TIMP4 Antikörper ist unkonjugiert

Applikation

  • 90
  • 59
  • 32
  • 31
  • 29
  • 13
  • 13
  • 9
  • 8
  • 7
  • 6
  • 3
  • 2
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Klon

9:4-7
  • Hersteller Produkt- Nr.

    200-301-e65

    Hersteller

    Rockland

    Verwendungszweck

    TIMP4 Antibody

    Kreuzreaktivität (Details)

    TIMP4 antibody is specific for human TIMP4 protein.

    Produktmerkmale

    Synonyms: mouse anti-TIMP4 antibody, Tissue inhibitor of metalloproteinase-4, Metalloproteinase inhibitor 4, TIMP-4, TIMP 4, TIMP4 antibody, anti-TIMP-4 antibody

    Aufreinigung

    Anti-TIMP4 was purified from clarified mouse ascetic fluid by Protein A chromatography followed by extensive dialysis against the buffer stated above.

    Sterilität

    Sterile filtered

    Immunogen

    Immunogen: Anti-TIMP4 (MOUSE) Monoclonal Antibody was produced in mouse by repeated immunizations with full length human TIMP4 protein followed by hybridoma development.

    Immunogen Type: Recombinant Protein

    Isotyp

    IgG2b kappa
  • Applikationshinweise

    Immunohistochemistry Dilution: 5-10 μg/mL

    Application Note: Anti-TIMP4 antibody has been tested for use in ELISA, Native - Western, and IHC (P). SDS-PAGE - Western Blot not useful for endogenous detection. Specific conditions for reactivity should be optimized by the end user.

    Western Blot Dilution: 1:2,000 to 1:10,000

    ELISA Dilution: 1:20,000 to 1:100,000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1.0 mg/mL

    Buffer

    Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

    Stabilizer: None

    Preservative: 0.01 % (w/v) Sodium Azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

    Haltbarkeit

    12 months
  • Donover, Wojciechowski, Thirumaran, Zemba-Palko, Prendergast, Wallon: "Development of a monoclonal antibody that specifically detects tissue inhibitor of metalloproteinase-4 (TIMP-4) in formalin-fixed, paraffin-embedded human tissues." in: Journal of cellular biochemistry, Vol. 110, Issue 5, pp. 1255-61, (2010) (PubMed).

  • Target

    TIMP4 (TIMP Metallopeptidase Inhibitor 4 (TIMP4))

    Andere Bezeichnung

    TIMP4

    Hintergrund

    Background: Tissue inhibitor of metalloproteinase-4 (TIMP-4) is member of the TIMP family of inhibitors of matrix metalloproteinase (MMP) activities. In addition, TIMPs have non-MMP associated functions, including roles in growth promotion, apoptosis, and angiogenesis. All four members of the TIMP gene family form a similar secondary structure due to the formation of six highly conserved disulfide bonds. It has been reported that some TIMPs, TIMP4 included, can bind a tetraspanin in the plasma membrane, initiating an intra-cellular signaling cascade. Elevated levels of TIMP4 have been associated with breast cancer progression and heart disease.

    Gen-ID

    7079

    NCBI Accession

    NM_003256

    UniProt

    Q99727
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