LGR4 Antikörper (Internal Region)

Produktnummer ABIN1043731

Produktdetails anti-LGR4 Antikörper

Target: LGR4 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 4 (LGR4))

Bindungsspezifität: Internal Region

Reaktivität: Human, Schimpanse, Makake

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LGR4 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: Anti-LGR4 Antibody product was purified from concentrated tissue culture supernate by Protein A chromatography. This antibody is specific for human LGR4 protein. A BLAST analysis was used to suggest cross-reactivity with LGR4 from chimpanzee, orangutan and macaque based on 100% homology with the immunizing sequence. Cross-reactivity with LGR4 from other sources has not been determined.

Produktmerkmale: LGR4, also known as leucine-rich repeat-containing G protein-coupled receptor 4, is a G protein-coupled receptors (GPCRs). GPCRs are membrane bound proteins that play key roles in a variety of physiologic functions. Members of the leucine-rich GPCR (LGR) family, such as GPR48, have multiple N-terminal leucine-rich repeats (LRRs) and a 7-transmembrane domain. LGR4 is an orphan GPCR reported to be expressed in steroidogenic tissues such as placenta, ovary, testis, adrenal, pancreas, prostate, and thyroid, as well as in spinal cord, stomach, heart, and kidney.

Sterilität: Sterile filtered

Immunogen: This LGR4 antibody was produced by repeated immunizations with a synthetic peptide corresponding to an internal region of human LGR4 protein. The hybridoma was produced by fusing BALB/c mouse splenocytes and mouse myeloma SP2/O cells using conventional technology.
Immunogen Type: Peptide

Klon: 6G8-B3-G5-C3

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise: Anti-LGR4 antibody is suitable for ELISA, immunohistochemistry and western blotting. Expect a band approximately 102 kDa in size corresponding to LGR4 protein by western blotting in the appropriate cell lysate or extract. Specific conditions for reactivity should be optimized by the end user. Use formalin-fixed paraffin-embedded sections for immunohistochemistry. No pre-treatment of sample is required.

Kommentare:

Gene Name: LGR4

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.

Haltbarkeit: 12 months

Referenzen für anti-LGR4 Antikörper (ABIN1043731)

Weng, Luo, Cheng, Jin, Zhou, Qu, Tu, Ai, Li, Wang, Martin, Amendt, Liu: "Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 16, pp. 6081-6, (2008) (PubMed).

Details zu LGR4

Target: LGR4 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 4 (LGR4))

Andere Bezeichnung: LGR4 (LGR4 Produkte)

Synonyme: BNMD17 antikoerper, GPR48 antikoerper, 9130225G07 antikoerper, A330106J01Rik antikoerper, A930009A08Rik antikoerper, Gpr48 antikoerper, leucine rich repeat containing G protein-coupled receptor 4 antikoerper, leucine-rich repeat-containing G protein-coupled receptor 4 antikoerper, LGR4 antikoerper, Lgr4 antikoerper

Hintergrund: LGR4, also known as leucine-rich repeat-containing G protein-coupled receptor 4, is a G protein-coupled receptors (GPCRs). GPCRs are membrane bound proteins that play key roles in a variety of physiologic functions. Members of the leucine-rich GPCR (LGR) family, such as GPR48, have multiple N-terminal leucine-rich repeats (LRRs) and a 7-transmembrane domain. LGR4 is an orphan GPCR reported to be expressed in steroidogenic tissues such as placenta, ovary, testis, adrenal, pancreas, prostate, and thyroid, as well as in spinal cord, stomach, heart, and kidney.
Synonyms: LGR4 leucine-rich repeat-containing G protein-coupled receptor 4

Gen-ID: 55366, 157694513

UniProt: Q8N537