SARS-Coronavirus Membrane Protein (SARS-CoV M) (N-Term) Antikörper

Produktnummer ABIN1031552

Der Kaninchen Polyklonal Anti--Antikörper wurde für ELISA validiert. Er ist geeignet, in Proben von SARS Coronavirus (SARS-CoV) zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für SARS-Coronavirus Membrane Protein (SARS-CoV M) (N-Term) Antikörper (ABIN1031552)

Target: SARS-Coronavirus Membrane Protein (SARS-CoV M)

Reaktivität: SARS Coronavirus (SARS-CoV)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: ELISA

Produktdetails

Bindungsspezifität: N-Term

Homologie: Predicted reactivity based on immunogen sequence: SARS-CoV2 Matrix protein: (identity 77%, homology 93%)

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: Anti-SARS-CoV Matrix antibody was raised against a peptide corresponding to 13 amino acids near the amino-terminus of SARS-CoV Matrix protein.
The immunogen is located within the first 50 amino acids of SARS-CoV Matrix.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: SARS-CoV Matrix antibody can be used for the detection of SARS-CoV Matrix protein in ELISA. It will detect 5 ng of free peptide at 1 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Antibody is supplied in PBS containing 0.02% sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: The antibody can be stored at 4 ˚ C for three months and -20 ˚ C, stable for up to one year.

Haltbarkeit: 12 months

Referenzen

Nuovo, Magro, Shaffer, Awad, Suster, Mikhail, He, Michaille, Liechty, Tili: "Endothelial cell damage is the central part of COVID-19 and a mouse model induced by injection of the S1 subunit of the spike protein." in: Annals of diagnostic pathology, Vol. 51, pp. 151682, (2020) (PubMed).

Antigendetails

Target: SARS-Coronavirus Membrane Protein (SARS-CoV M)

Andere Bezeichnung: SARS-CoV M Protein

Substanzklasse: Viral Protein

Hintergrund: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus. The disease is the cause of the 2019–20 coronavirus outbreak. The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. The membrane (M) protein or matrix protein is the most abundant structural protein and defines the shape of the viral envelope. It is an integral membrane protein involved in the budding of the viral particles and interacts with S (Spike) protein. It involves in organization of the nucleoprotein inside, which includes many copies of the N (nucleocapsid) protein bound to the genomic RNA. The M protein holds dominant cellular immunogenicity and has been determined as a protective antigen in humoral responses, which suggests it would serve as a potential target in vaccine design.

Gen-ID: 1489672

NCBI Accession: P59596