TCR gamma/delta Antikörper (PE)

Produktnummer ABIN1027689

Produktdetails anti-TCR gamma/delta Antikörper (PE)

Target: TCR gamma/delta (T-Cell Receptor gamma/delta (TCR gamma/delta))

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TCR gamma/delta Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Spezifität: The mouse monoclonal antibody V65 recognizes an extracellular epitope of TCR gamma/delta, the subtype of T cell receptor expressed mainly in epithelial tissues and at the sites of infection.

Kreuzreaktivität (Details): Rat

Aufreinigung: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: TCR alpha/beta-negative CD3-positive rat T cell hybridoma III.89.1.4 line

Klon: V65

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Flow cytometry: Recommended dilution: 1-2 μg/mL.

Kommentare:

The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze.
Avoid prolonged exposure to light.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Referenzen für anti-TCR gamma/delta Antikörper (PE) (ABIN1027689)

De Bernardis, Lucciarini, Boccanera, Amantini, Arancia, Morrone, Mosca, Cassone, Santoni: "Phenotypic and functional characterization of vaginal dendritic cells in a rat model of Candida albicans vaginitis." in: Infection and immunity, Vol. 74, Issue 7, pp. 4282-94, (2006) (PubMed).

van den Brandt, Kwon, Hünig, McPherson, Reichardt: "Sustained pre-TCR expression in Notch1IC-transgenic rats impairs T cell maturation and selection." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 12, pp. 7845-52, (2005) (PubMed).

Moghaddami, Cleland, Mayrhofer: "MHC II+ CD45+ cells from synovium-rich tissues of normal rats: phenotype, comparison with macrophage and dendritic cell lineages and differentiation into mature dendritic cells in vitro." in: International immunology, Vol. 17, Issue 8, pp. 1103-15, (2005) (PubMed).

Xystrakis, Dejean, Bernard, Druet, Liblau, Gonzalez-Dunia, Saoudi: "Identification of a novel natural regulatory CD8 T-cell subset and analysis of its mechanism of regulation." in: Blood, Vol. 104, Issue 10, pp. 3294-301, (2004) (PubMed).

Henriksson, Helgeland, Midtvedt, Stierna, Brandtzaeg: "Immune response to Mycoplasma pulmonis in nasal mucosa is modulated by the normal microbiota." in: American journal of respiratory cell and molecular biology, Vol. 31, Issue 6, pp. 657-62, (2004) (PubMed).

Hosea, Rector, Taylor: "Zinc-deficient rats have fewer recent thymic emigrant (CD90+) T lymphocytes in spleen and blood." in: The Journal of nutrition, Vol. 133, Issue 12, pp. 4239-42, (2003) (PubMed).

Giezeman-Smits, Jonges, Chambers, Brisette-Storkus, Van Vlierberghe, Van Eendenburg, Eggermont, Fleuren, Kuppen: "Novel monoclonal antibodies against membrane structures that are preferentially expressed on IL-2-activated rat NK cells." in: Journal of leukocyte biology, Vol. 63, Issue 2, pp. 209-15, (1998) (PubMed).

Details zu TCR gamma/delta

Target: TCR gamma/delta (T-Cell Receptor gamma/delta (TCR gamma/delta))

Andere Bezeichnung: TCR gamma/delta (TCR gamma/delta Produkte)

Hintergrund: The antigen-specific T cell receptor (TCR) is composed of either alpha and beta subunit, or gamma and delta subunit. Majority of T cells present in the blood, lymph and secondary lymphoid organs express TCR alpha/beta heterodimers, whereas the T cells expressing TCR gamma/delta heterodimers are localized mainly in epithelial tissues and at the sites of infection. The subunits of TCR heterodimers are covalently bonded and in the endoplasmic reticulum they associate with CD3 subunits to form functional TCR-CD3 complex. Lack of expression of any of the chains is sufficient to stop cell surface expression.,TCRG/D