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CAMKK2 exhibited the strongest associations with HIV-associated sensory neuropathy (HIV-SN), with two SNPs and six haplotypes predicting SN status in black Southern Africans.
Study used three cognitive tasks and fMRI to provide convergent evidence of a link between the rs1063843 SNP of CAMKK2 and the function of the dorsolateral prefrontal cortex. In addition, this polymorphism was associated with the function of the striatum during a working memory task.
Data suggest that CAMKK2 is highly expressed in high-grade ovarian cancer and ovarian cancer cell lines; CAMKK2 directly activates Akt1 by phosphorylation at Thr-308 in a Ca2+/calmodulin-dependent manner; CAMKK2 knockdown or inhibition decreases Akt1 phosphorylation at Thr-308 and Ser-473. (CAMKK2 = calcium/calmodulin dependent protein kinase kinase 2; AKT1 = AKT serine/threonine kinase 1)
Single nucleotide polymorphism in CAMKK2 gene is associated with pulmonary non-tuberculous mycobacterial disease.
This study showed that the expression level of CAMKK2 could be regulated by promoter methylation. CAMKK2 serves as a prognostic marker in gliomas and could be a potential therapeutic target in gliomas.
For the first time, we showed that rs1063843, a single nucleotide polymorphism located in the CAMKK2 gene, is highly associated with bipolar disorder
Site-directed mutagenesis analysis revealed that Leu(358) in CaMKKbeta/Ile(322) in CaMKKalpha confer, at least in part, a distinct recognition of AMPK (zeige PRKAA1 Proteine) but not of CaMKIalpha (zeige CAMK1 Proteine).
Clopidogrel diminishes TNFalpha (zeige TNF Proteine)-stimulated VCAM-1 (zeige VCAM1 Proteine) expression at least in part via HO-1 (zeige HMOX1 Proteine) induction and CaMKKbeta/AMPK (zeige PRKAA1 Proteine)/Nrf2 (zeige GABPA Proteine) pathway in endothelial cells.
CaMKK2 (and Nup62 (zeige NUP62 Proteine)) are required for optimal androgen receptor (zeige AR Proteine) transcriptional activity in castrate resistant prostate cancer cells.
Silencing of CAMKK2 using siRNA significantly reduced cell proliferation, colony formation and invasion of gastric cancer cells.
we demonstrated that systemic administration of the small molecule CaMKK2 inhibitor, STO-609, to irradiated mice enhanced Hematopoietic stem and progenitor cells (HSPCs)recovery and improved survival. These findings identify CaMKK2 as an important regulator of HSPC (zeige PSMA7 Proteine) regeneration and demonstrate CaMKK2 inhibition is a novel approach to promoting hematopoietic recovery after BM injury.
loss of blood-brain barrier proteins, inactivation of survival gene expression such as B-cell lymphoma 2 (Bcl-2 (zeige BCL2 Proteine)) and an increase in inflammatory cytokines in the serum were observed after stroke with CaMKK beta inhibition. We demonstrate that CaMKK beta is neuroprotective in stroke in aged mice
CaMKK2 as a molecular rheostat for insulin (zeige INS Proteine) action.
CaMKK2 Inhibits C2C12 Myoblasts Proliferation and Differentiation through AMPK (zeige PRKAA1 Proteine). Overexpression of CaMKK2 Inhibits Muscle Regeneration in Vivo.
In summary, we demonstrate a new mechanism of calcium dependent antibacterial strategy in E. coli infected macrophages, which requires autophagy enhancement mediated by activation of CaMKKbeta, ERK (zeige EPHB2 Proteine), AMPK (zeige PRKAA1 Proteine) and FoxO1 (zeige FOXO1 Proteine).
CaMKKbeta exerts protective effects on cardiac adaptive energy pooling against pressure-overload possibly through phosphorylation of AMPK and by upregulation of PGC-1alpha.
Results demonstrated that genetically inhibiting the CaMKK pathway via CaMKKbeta or CaMK IV (zeige CAMK4 Proteine) is detrimental in the response of female mice to cerebral ischemia
a novel function for CaMKK2 in bone remodeling and highlight the potential for its therapeutic inhibition as a valuable bone anabolic strategy that also inhibits OC differentiation in the treatment of osteoporosis.
Flow-enhanced sirtuin (zeige SIRT1 Proteine) (SIRT)1 (zeige SIRT1 Proteine) stability is primarily mediated by CaMKKbeta phosphorylation of sirtuin SIRT1 (zeige SIRT1 Proteine) at Ser (zeige SIGLEC1 Proteine)-27 and Ser (zeige SIGLEC1 Proteine)-47.
amino acid starvation regulates autophagy in part through an increase in cellular Ca(2 (zeige CA2 Proteine)+) that activates a CaMKK-beta-AMPK (zeige PRKAA1 Proteine) pathway and inhibits mTORC1, which results in ULK1 (zeige ULK1 Proteine) stimulation
the expression, but not the kinase activity, of AMPK (zeige PRKAA1 Proteine) and CaMKKbeta is necessary for ADP signaling to eNOS (zeige NOS3 Proteine)
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases.
CAMKK beta protein
, caM-KK 2
, caM-KK beta
, caM-kinase kinase 2
, caM-kinase kinase beta
, calcium/calmodulin-dependent protein kinase beta
, calcium/calmodulin-dependent protein kinase kinase 2
, caMKK 2
, caMKK beta
, calcium/calmodulin-dependent protein kinase kinase beta
, calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1
, protein-tyrosine kinase
, calcium/calmodulin-dependent protein kinase II beta
, calcium/calmodulin-dependent protein kinase kinase 2, beta
, calcium/calmodulin-dependent protein kinase kinase 2-like
, Ca+/Calmodulin-dependent protein kinase kinase beta (CaM-kinase kinase beta)
, CaM-kinase kinase beta
, calcium/calmodulin-dependent protein kinase 2 beta