RIPK3 Proteine (RIPK3)

Human Receptor-Interacting serine-threonine Kinase 3 (RIPK3) Interaktionspartner

1. The necroptosis-inducing kinase RIPK3 reduces adipose tissue inflammation and glucose intolerance.

2. We showed that RIP3 spontaneously drives a necroptosis-induced inflammation in established intestinal cell lines and in ileal/colonic samples from IBD patients.

3. These data demonstrate that caspase-8 (zeige CASP8 Proteine) functions in synovial antigen-presenting cells to regulate the response to inflammatory stimuli by controlling RIPK3 action, and this delicate balance maintains homeostasis within the joint.

4. The induced expression of RIP3 by UHRF1 (zeige UHRF1 Proteine) RNAi depends on the presence of Sp1 (zeige PSG1 Proteine). Remarkably, the ectopic expression of RIP3 in RIP3-null cancer cells results in a decrease in tumor growth in mice. Therefore, our findings offer insights into RIP3 expression control in cancer cells and suggest an inhibitory effect of RIP3 on tumorigenesis.

5. 2-hydroxyglutarate bound to DNMT1 (zeige DNMT1 Proteine) and stimulated its association with the RIP3 promoter, inducing hypermethylation that reduces RIP3 protein and consequently impaired RIP3-dependent necroptosis.

6. the in vivo effects were diametrically reversed with RIP3 deletion or RIP1 (zeige UQCRFS1 Proteine) blockade, resulting in marked tumor protection. The dichotomy between the in vivo and in vitro results suggests that the microenvironmental milieu resulting from RIP1 (zeige UQCRFS1 Proteine)/RIP3 signaling is likely responsible for its protumorigenic effects

7. Shikonin induces glioma cell necroptosis in vitro by reactive oxygen species overproduction and promoting RIP1 (zeige UQCRFS1 Proteine)/RIP3 necrosome formation.

8. In critically ill trauma patients, plasma levels of the necroptosis mediator RIP3 at 48 h were associated with AKI stage and RBC (zeige CACNA1C Proteine) transfusions.

9. our results reveal that the necroptosis adaptor RIPK3 has key anti-inflammatory and anti-tumoral functions in the intestine, and define RIPK3 as a novel colon tumor suppressor

10. adhesion-induced eosinophil cytolysis takes place through RIPK3-MLKL-dependent necroptosis, which can be counterregulated by autophagy

Mouse (Murine) Receptor-Interacting serine-threonine Kinase 3 (RIPK3) Interaktionspartner

1. The necroptosis-inducing kinase RIPK3 reduces adipose tissue inflammation and glucose intolerance.

2. RIP3-mediated signaling is not a critical driver of acute radiation syndrome

3. RIPK3 promotes adenovirus type 5 oncolytic activity.

4. p55TNFR-IKK2 (zeige IKBKB Proteine)-Ripk3 signalling orchestrates arthritogenic and death responses in synovial fibroblasts

5. in Mycobacterium tuberculosis-infected macrophages, mitochondria are an essential platform for induction of necrosis by activating RIPK3 function and preventing caspase 8 (zeige CASP8 Proteine)-activation.

6. Ripk3 promotes mitochondrial apoptosis via inhibition of FUNDC1 (zeige FUNDC1 Proteine) mitophagy in cardiac ischemia reperfusion injury.

7. The authors report here that male reproductive organs of both Ripk3- and Mlkl-knockout mice retain 'youthful' morphology and function into advanced age, while those of age-matched wild-type mice deteriorate. Feeding of wild-type mice with an RIPK1 (zeige RIPK1 Proteine) inhibitor prior to the normal onset of age-related changes in their reproductive organs blocked the appearance of signs of aging.

8. These data demonstrate a role for RIP3 in promoting in vivo thrombosis and hemostasis by amplifying platelet activation. RIP3 may represent a novel promising therapeutic target for thrombotic diseases.

9. these results demonstrated that RIPK3-mediated signaling in Tie-2 expressing cells was responsible for the embryonic lethality of Fadd-/- with cardiac failure.

10. Pull down experiments with biotinylated Sorafenib show that it binds independently RIPK1 (zeige RIPK1 Proteine), RIPK3 and MLKL. Moreover, it inhibits RIPK1 (zeige RIPK1 Proteine) and RIPK3 kinase activity. In vivo Sorafenib protects against TNF (zeige TNF Proteine)-induced systemic inflammatory response syndrome (SIRS) and renal ischemia-reperfusion injury (IRI).