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anti-Rat (Rattus) MMP2 Antikörper:
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Chicken Polyclonal MMP2 Primary Antibody für ICC, IF - ABIN152329
Krekoski, Neubauer, Graham, Muir: Metalloproteinase-dependent predegeneration in vitro enhances axonal regeneration within acellular peripheral nerve grafts. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2002
Show all 39 Pubmed References
Human Polyclonal MMP2 Primary Antibody für ELISA, ICC - ABIN4886669
Zhang, Chen, Qi, Wang, Xiao, Zhu: Inhibition of calcium-calmodulin-dependent kinase II suppresses cardiac fibroblast proliferation and extracellular matrix secretion. in Journal of cardiovascular pharmacology 2010
Show all 25 Pubmed References
Human Polyclonal MMP2 Primary Antibody für IHC (fro), IHC (p) - ABIN3044339
Li, Xu, Chu, Gao, Wang, Nie, Yang, Lv: Molecular mechanism of inhibitory effects of CD59 gene on atherosclerosis in ApoE (-/-) mice. in Immunology letters 2013
Show all 25 Pubmed References
Human Polyclonal MMP2 Primary Antibody für IF (p), IHC (p) - ABIN668286
Wu, Fan, Zhang, Ning, Zeng, Zhou, Li, Chen, Zhang, Wang, Hsieh, He: PI3K/Akt to GSK3?/?-catenin signaling cascade coordinates cell colonization for bladder cancer bone metastasis through regulating ZEB1 transcription. in Cellular signalling 2012
Show all 14 Pubmed References
Human Monoclonal MMP2 Primary Antibody für ICC, IHC (fro) - ABIN152258
Locke, Royce, Wainewright, Samuel, Tang: Comparison of airway remodeling in acute, subacute, and chronic models of allergic airways disease. in American journal of respiratory cell and molecular biology 2007
Show all 13 Pubmed References
Human Polyclonal MMP2 Primary Antibody für ELISA, ICC - ABIN6263299
Li, Zhang, Sun, Sun, Shi, Liu, Liu: MicroRNA-181a regulates epithelial-mesenchymal transition by targeting PTEN in drug-resistant lung adenocarcinoma cells. in International journal of oncology 2016
Show all 9 Pubmed References
Human Polyclonal MMP2 Primary Antibody für IF (p), IHC (p) - ABIN707426
Cavdar, Ozbal, Celik, Ergur, Guneli, Ural, Camsari, Guner: The effects of alpha-lipoic acid on MMP-2 and MMP-9 activities in a rat renal ischemia and re-perfusion model. in Biotechnic & histochemistry : official publication of the Biological Stain Commission 2014
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Guinea Pig Monoclonal MMP2 Primary Antibody für ELISA, ICC - ABIN152257
Rork, Hadzimichalis, Kappil, Merrill: Acetaminophen attenuates peroxynitrite-activated matrix metalloproteinase-2-mediated troponin I cleavage in the isolated guinea pig myocardium. in Journal of molecular and cellular cardiology 2006
Show all 3 Pubmed References
Human Monoclonal MMP2 Primary Antibody für ELISA, WB - ABIN1098146
Langers, Verspaget, Hawinkels, Kubben, van Duijn, van der Reijden, Hardwick, Hommes, Sier: MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients. in British journal of cancer 2012
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Human Monoclonal MMP2 Primary Antibody für ELISA, ICC - ABIN451535
Siddesha, Valente, Yoshida, Sakamuri, Delafontaine, Iba, Noda, Chandrasekar: Docosahexaenoic acid reverses angiotensin II-induced RECK suppression and cardiac fibroblast migration. in Cellular signalling 2014
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study demonstrated that matrix metalloproteinase 1 (zeige MMP1 Antikörper) and 2 might be fundamental for events related to equine tissue remodeling, which occurs during follicular development
inhibition of ECM (zeige MMRN1 Antikörper) degradation by inhibition of matrix metalloproteinase 2 (Mmp2) to preserve the extracellular environment characteristics of young adults led to increased dendrite regeneration
Data indicate that matrix metalloproteinases mmp1 (zeige MMP1 Antikörper) and mmp2 mutants have distinct heart phenotypes.
We also show that follicular OA-Oamb signaling induces Mmp2 enzymatic activation but not Mmp2 protein expression, likely via intracellular Ca2 (zeige CA2 Antikörper)+ as the second messenger.
Finally, matrix metalloproteinase 2 (Mmp2), a type of protease thought to facilitate mammalian ovulation, is expressed in mature follicle and corpus luteum cells.
As a Wnt (zeige WNT4 Antikörper) signaling antagonist, MMP2 cleaves the glypican (zeige GPC1 Antikörper), reducing the ability of Dlp (zeige DMD Antikörper) to interact with the Wnt (zeige WNT4 Antikörper) ligand and promote its distribution.
Matrix metalloproteinase 2 is required for fat-body remodeling in Drosophila
Drosophila MMP2 regulates the matrix molecule faulty attraction (Frac) to promote motor axon targeting in Drosophila.
Dendrite reshaping of adult Drosophila sensory neurons requires matrix metalloproteinase MMP2-mediated modification of the basement membranes
Mmp2 expression in the developing air sac (zeige ADCY10 Antikörper) is controlled by the Drosophila FGF homolog Branchless and then participates in a negative feedback and lateral inhibition mechanism that defines the precise pattern of FGF signaling.
findings demonstrate a critical role for Mmp2 in tubulogenesis post-induction, and implicate Mmp2 in regulating dynamic and essential changes to the extracellular matrix
Mmp2 facilitates endothelial-to-hematopoietic transition via ECM (zeige MMRN1 Antikörper) remodeling.
Dexamethasone and hydrocortisone alter expression and activity of MMP-2 and MMP-9 (zeige MMP9 Antikörper) in the embryonic zebrafish.
In obese mice, periodontitis caused the downregulation of MMP2, and upregulation of TIMP1 (zeige TIMP1 Antikörper) and TGF-beta1 (zeige TGFB1 Antikörper) at transcriptional and translational levels.
In the initial periods of AP progression, an increased expression of MMP9 (zeige MMP9 Antikörper) in the TLR2 KO and MyD88 (zeige MYD88 Antikörper) KO mice was observed. In the final periods of AP progression, a reduction of MMP2 expression and an increase of MMP9 (zeige MMP9 Antikörper) expression in the TLR2 KO mice were observed. MMP2 and MMP9 (zeige MMP9 Antikörper) production was modulated for TLR2 and MyD88 (zeige MYD88 Antikörper) during apical periodontitis progression
MMP-2 promoted and MMP-13 (zeige MMP13 Antikörper) disrupted vasculogenic mimicry formation in large cell lung cancer by cleaving laminin-5 to influence EGFR (zeige EGFR Antikörper) signal activation.
Diet and exercise affect atheromatous MMP2/9 activity by modulating the systemic inflammatory milieu, with sVCAM-1, resistin, and adiponectin closely interacting with each other and with visceral fat.
calpains inhibition plays crucial roles in vascular restenosis by preventing neointimal hyperplasia at the early stage via suppression of the MMP2/TGF-beta1 (zeige TGFB1 Antikörper) pathway.
Aneurysmal-prone factors induced HIF-1alpha (zeige HIF1A Antikörper) can cause overexpression of MMP-2 and MMP-9 (zeige MMP9 Antikörper) and promote aneurysmal progression.
These studies illustrated an important role of MMP2 in cognitive and motor behaviors and confirm its importance in NPC (zeige NPC1 Antikörper) activities crucial to brain development, growth and response to and recovery from injury.
Secretagogin (zeige SCGN Antikörper)-dependent MMP2 release from neurons regulates neuroblast migration.
matrix metalloproteinase 2 (Mmp2) transcript is a target of miR (zeige MLXIP Antikörper)-195a-3p, and that silencing Mmp2 phenocopied the reduced proliferation and migration of MSCs. The therapeutic potential of miR (zeige MLXIP Antikörper)-195a-3p as an angiogenesis inhibitor was also demonstrated in a laser-induced choroidal neovascularization mouse model.
developed a novel selective radiolabeled MMP2/9 inhibitor, suitable for single photon emission computed tomography (SPECT) imaging that effectively targets atherosclerotic lesions in mice
that miR (zeige MLXIP Antikörper)-338-5p has a function in promoting glioma cell invasion by targeting TSHZ3 (zeige ZNF537 Antikörper) suppression on MMP2
In dilation cardiomyopathy, expression of MMP-2, MMP-9 (zeige MMP9 Antikörper), and TIMP-1 (zeige TIMP1 Antikörper) and their ratios in autopsy material and in cultures was elevated by 1.5-9 times.
OSM (zeige OSM Antikörper) [oncostatin M (zeige OSM Antikörper)]might be involved in the invasiveness of extravillous trophoblasts under hypoxia conditions via increasing MMP-2 and MMP-9 (zeige MMP9 Antikörper) enzymatic activities through STAT3 (zeige STAT3 Antikörper) signaling. Increased MMP-9 (zeige MMP9 Antikörper) activity by OSM (zeige OSM Antikörper) seems to be more important in primary trophoblasts.
TIMP2 (zeige TIMP2 Antikörper) promotes tumor progression and miR2055p directly regulates TIMP2 (zeige TIMP2 Antikörper), thereby suppressing proMMP2 activation and inhibiting oral squamous cell carcinoma cell invasiveness.
Elevated MMP-2 levels were observed in blood of pancreatic cancer patients which correlated with its tissue expression. However, these levels did not associate with survival or any clinicopathological parameters of patients.
2G allele of MMP-1 (zeige MMP1 Antikörper), C allele of MMP-2 and 5A/6A genotype of MMP-3 (zeige MMP3 Antikörper) are associated with susceptibility and disease progression of type 2 diabetic nephropathy
Increased urinary concentration of matrix metallopeptidase 2 (MMP-2) at 12 and 16 weeks of gestation predicted an increased risk of developing preeclampsia in the study population.
There was no difference found in MMP-2, MMP-9 (zeige MMP9 Antikörper) or TLR-4 (zeige TLR4 Antikörper) levels between non-thrombocytopenic and thrombocytopenic septic donors. PLA formation was increased in thrombocytopenic patients.
MMP2 rs243865 was the only single nucleotide polymorphism significantly associated with Floppy Mitral Valve/Mitral Valve Prolapse (FMV/MVP (zeige MVP Antikörper)) as compared to the control.The frequency of certain MMP2 polymorphisms is higher in patients with the FMV/MVP (zeige MVP Antikörper) syndrome and patients with FMV/MVP (zeige MVP Antikörper) without the syndrome.
Specific silencing that targeted AMPK (zeige PRKAA1 Antikörper) resulted in the enhancement of mobility and contractility and in the production of MMP-1 (zeige MMP1 Antikörper) and MMP-2.
this study shows that differential FFAR1 (zeige FFAR1 Antikörper) signaling is associated with gene expression or gelatinase granule release in bovine neutrophils
NADPH oxidase (zeige NOX1 Antikörper) plays an important role in proMMP-2 expression and activation and MMP-2 mediated SMC (zeige DYM Antikörper) proliferation occurs through the involvement of Spm (zeige NPC1 Antikörper)-Cer (zeige CBLN1 Antikörper)-S1P (zeige MBTPS1 Antikörper) signaling axis under ANG II (zeige AGT Antikörper) stimulation of PASMCs
The expression patterns of MMP1 (zeige MMP1 Antikörper), MMP2, and MMP8 (zeige MMP8 Antikörper) were explored during fetal and postnatal development of longissimus dorsi muscle in cattle, and the relationships of MMP1 (zeige MMP1 Antikörper), MMP2, and MMP8 (zeige MMP8 Antikörper) expression levels with meat quality traits were analyzed in cattle. The expression of MMP1 (zeige MMP1 Antikörper), MMP2, and MMP8 (zeige MMP8 Antikörper) were also tested in four kinds of fat tissues and three kinds of skeletal muscle tissues.
The results showed that a decrease in MMP-1 (zeige MMP1 Antikörper) and MMP-2 gene expression is accompanied with a decrease in NO concentrations in infertile cows affected with ovarian cysts.
Activation of cytosolic MMP-9 (zeige MMP9 Antikörper) and MMP-2 was investigated in the retinal endothelial cells incubated in high glucose for 6-96 h, and correlated with their mitochondrial accumulation and mitochondrial damage.
Data indicate the involvement of PKC-alpha (zeige PKCa Antikörper) in proMMP-2 activation and inhibition of TIMP-2 (zeige TIMP2 Antikörper) expression by NF-kappaB (zeige NFKB1 Antikörper)-MT1-MMP (zeige MMP14 Antikörper)-dependent and -independent pathway.
Data suggest that EMMPRIN derived from endometrial epithelial cells regulates expression of matrix metalloproteinases (MMP-2; MMP-14 (zeige MMP14 Antikörper)) in endometrial stromal cells; expression of stromal MMPs is significantly higher in coculture with epithelial cells.
Adding pure bovine MMP-2 to the smooth muscle membrane suspension causes an increase in Ca(2+)-ATPase (zeige CA-P60A Antikörper) activity, but the pretreatment with TIMP-2 (zeige TIMP2 Antikörper) inhibits the increase in the enzyme activity
A differential pattern of matrix metalloproteinase-2 and Tissue inhibitor metalloproteinase-2 was observed in cow uteri with adenomyosis.
MMP-14 (zeige MMP14 Antikörper), MMP-2 and TIMP-2 (zeige TIMP2 Antikörper) are co-localized in the fetal compartment and therefore could influence the timely release of fetal membranes in cattle.
we demonstrated the presence of high molecular weight (HMW) complexes (130, 170, and 220 kDa) containing MMP9 (zeige MMP9 Antikörper), TIMP1 (zeige TIMP1 Antikörper), and NGAL (zeige LCN2 Antikörper) (also MMP2 in 220 kDa complex) without proteolytic activity.
Data demonstrate for the first time that MMP2 and MMP9 (zeige MMP9 Antikörper) are expressed in swine ovarian follicle both in theca and granulosa layers.
FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 (zeige MMP9 Antikörper) and MMP-2, caspase-3 (zeige CASP3 Antikörper) and BDNF (zeige BDNF Antikörper)
MMP-2 may play an important role in regulating MLC1 turnover in the heart under normal physiological conditions
Oxygen for newborn resuscitation increases MMP-2/-9 activity resulting in tissue damage and influencing remodeling processes.
PI3K-dependent regulation of MT1-MMP (zeige MMP14 Antikörper) protein synthesis and subsequent activation of latent MMP-2 as critical events in neointimal hyperplasia after vascular injury.
MMP-2 processes dental sialophosphoprotein into smaller subunits in the dentin matrix during odontogenesis
contribution of MMPs to the inflammatory breakdown of the blood-CSF (zeige CSF2 Antikörper) barrier in vitro
The levels of matrix metalloproteinase-2 and matrix metalloproteinase-9 (zeige MMP9 Antikörper) in the corpus luteum of swine during luteolysis are reported.
Hemodialysis graft placement leads to early increases in wall shear stress, VEGF-A (zeige VEGFA Antikörper), pro-MMP-9 (zeige MMP9 Antikörper), MMP-2, VEGFR-1 (zeige FLT1 Antikörper), VEGFR-2 (zeige KDR Antikörper), and TIMP-1 (zeige TIMP1 Antikörper), which may contribute to the development of venous stenosis.
Selenium suppressed high-fat diet-induced MMP2 over-expression in vivo by improving lipid metabolism.
Inflammatory factors such as TNF-alpha (zeige TNF Antikörper) can stimulate MMP-2/9 activity in corneal epithelium cells. This may be a potential manipulating mechanism of MMP expression in the pathogenesis of corneal diseases
Results provide evidence that MMP-2 bears the potentiality to cleave alpha-DG enriched from rabbit skeletal muscle indicating that this degradation indeed might also occur in vivo.
In conclusion, MMP-2 could be responsible for the proteolysis of dystrophin (zeige DMD Antikörper).
Castor (zeige CASZ1 Antikörper) oil polymer induces bone formation with high matrix metalloproteinase-2 expression.
MMP2 spinal cord expression is increased in cervical spondylotic myelopathy.
Ulinastatin (zeige AMBP Antikörper) effectively inhibited the increased expression of MMP-2, MMP-3 (zeige MMP3 Antikörper), and iNOS (zeige NOS2 Antikörper) in degenerated NP cells induced by IL-1beta (zeige IL1B Antikörper) in vitro.
Hemoperfusion could obviously reduce oxidative stress and the expression levels of MMP-2, MMP-9 (zeige MMP9 Antikörper) and TIMP-1 (zeige TIMP1 Antikörper) in rabbits with acute paraquat poisoning.
The RNA interference targeting COX-2 (zeige COX2 Antikörper) can effectively inhibit the expression of COX-2 (zeige COX2 Antikörper) and MMP-2 in IL-1alpha stimulated rabbit corneal stromal cells in vitro.
Our results strongly suggest that ischaemic postconditioning may exert part of its cardioprotective effects through the inhibition of MMP-2 activity.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene.
, matrix metalloprotease 2
, matrix metalloproteinase
, matrix metalloproteinase 2
, 72 kDa type IV collagenase
, Gelatinase A
, matrix metalloproteinase-2
, 72 kDa gelatinase
, gelatinase A
, 72kD gelatinase
, 72kD type IV collagenase
, 72kDa gelatinase
, 72kDa type IV collagenase
, collagenase type IV-A
, matrix metalloproteinase-II
, neutrophil gelatinase
, matrix metalloproteinase 2 (72 KDa type IV collagenase)
, matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)