anti-MMP2 (MMP2) Antikörper

Horse (Equine) Matrix Metalloproteinase 2 (MMP2) Interaktionspartner

1. potential activity 1.4 times higher in control placentas than in placentas of mares retaining fetal membranes

2. study demonstrated that matrix metalloproteinase 1 and 2 might be fundamental for events related to equine tissue remodeling, which occurs during follicular development

Fruit Fly (Drosophila melanogaster) Matrix Metalloproteinase 2 (MMP2) Interaktionspartner

1. there are only two MMP genes in Drosophila, DmMmp1 and DmMmp2, which makes Drosophila an attractive system to analyze the basis of MMP specificity. Previously, Drosophila MMPs have been categorized by their pericellular localization, as Mmp1 appeared to be secreted and Mmp2 appeared to be membrane-anchored, suggesting that protein localization was the critical distinction in this small MMP family

2. inhibition of ECM degradation by inhibition of matrix metalloproteinase 2 (Mmp2) to preserve the extracellular environment characteristics of young adults led to increased dendrite regeneration

3. Data indicate that matrix metalloproteinases mmp1 and mmp2 mutants have distinct heart phenotypes.

4. We also show that follicular OA-Oamb signaling induces Mmp2 enzymatic activation but not Mmp2 protein expression, likely via intracellular Ca2+ as the second messenger.

5. Finally, matrix metalloproteinase 2 (Mmp2), a type of protease thought to facilitate mammalian ovulation, is expressed in mature follicle and corpus luteum cells.

6. As a Wnt signaling antagonist, MMP2 cleaves the glypican, reducing the ability of Dlp to interact with the Wnt ligand and promote its distribution.

7. Matrix metalloproteinase 2 is required for fat-body remodeling in Drosophila

8. Drosophila MMP2 regulates the matrix molecule faulty attraction (Frac) to promote motor axon targeting in Drosophila.

9. Dendrite reshaping of adult Drosophila sensory neurons requires matrix metalloproteinase MMP2-mediated modification of the basement membranes

10. Mmp2 expression in the developing air sac is controlled by the Drosophila FGF homolog Branchless and then participates in a negative feedback and lateral inhibition mechanism that defines the precise pattern of FGF signaling.

11. complete base sequence given for a 758 residue polypeptide

12. Drosophila matrix metalloproteinases are required for tissue remodeling, but not embryonic development.

13. MMP activity is essential for embryonic motor axon fasciculation

14. findings demonstrate a critical role for Mmp2 in tubulogenesis post-induction, and implicate Mmp2 in regulating dynamic and essential changes to the extracellular matrix

Zebrafish Matrix Metalloproteinase 2 (MMP2) Interaktionspartner

1. Mmp2 facilitates endothelial-to-hematopoietic transition via ECM remodeling.

2. membrane-type 1 metalloproteinase, zmmp-2, and tissue inhibitor 2 of metalloproteinases mRNA transcripts were expressed in the blastema

3. Dexamethasone and hydrocortisone alter expression and activity of MMP-2 and MMP-9 in the embryonic zebrafish.

Mouse (Murine) Matrix Metalloproteinase 2 (MMP2) Interaktionspartner

1. SOST(transgenic) had approximately 2-fold less MMP activation than WT or Sost(-/-) , and this was supported by a significant reduction in MMP2/3 protein levels.

2. These results suggest a mechanism for leptin resistance through activation of Mmp-2 and subsequent cleavage of the extracellular domain of the leptin receptor.

3. This study discovered a feedback loop where sustained activation of P2X7 triggers release of active matrix metalloproteinase 2 (MMP-2), which halts ion channel and large pore responses via the MMP-2-dependent receptor cleavage.

4. Our study demonstrated that hypoxia increases the expression of MMP-2 and MMP-9 through the 15-lipoxygenase/15-HETE pathway, and that MMP-2 and MMP-9 promote PAEC angiogenesis. These findings suggest that MMP-2 and MMP-9 may serve as new potential therapeutic targets for the treatment of pulmonary arterial hypertension (PAH).

5. These data suggest that FAK/PI3K/Akt signaling pathway and MMP-2 and MMP-9 may be involved in the development of Herpes Simplex Keratitis.

6. In the tem-poromandibular joint tissues of the young mice type I collagen and MMP-2 expressions were increased, while they were decreased in old mice. In the MMP-2 H-score evaluation young mice showed significant increase compared to the old mice.

7. Osteoglycin negatively regulates cardiac fibrotic remodelling by attenuating myofibroblast proliferation and migration through LPA3-mediated and Rho/ROCK-dependent inhibition of MT1-MMP translocation, MMP2 activation and EGFR transactivation.

8. data strongly suggest that PARP-1 inhibition blunts elastase-induced MMP-2 and MMP-9 expression, which may be partly responsible for prevention of emphysema.

9. Transfection with either a mimic or an inhibitor of miR-29b-1-5p confirmed that downregulation of PHLPP1 upregulates Akt-dependent NF-kappaB signalling leading to activation of matrix metalloproteinases 2 and 9, players in the degradation of extracellular matrix during Helicobacter pylori infection.

10. High MMP2 expression is associated with Myopia Development.

11. While the general principles concerning MMP-2 and MMP-9 function discussed here are relevant to all inflammatory situations, the details regarding substrates and molecular mechanisms of action are likely to be specific for neuroinflammation.

12. Investigated whether electrical stimulation could enhance the regeneration of injured neurites in dorsal root ganglion explants and regulate the MMP-2 expression level, which is correlated with regeneration. Significantly increased neurite regeneration and MMP-2 expression were observed in the ES group compared with the sham group.

13. the aim of this study was to determine whether Acanthamoeba spp. may affect the levels of matrix metalloproteinases (MMP-2,-9), their tissue inhibitors (TIMP-1,-3) and MMP-9/TIMP-1, MMP-2/TIMP-3 ratios in the cerebral cortex and hippocampus, in relation to the host's immunological status.

14. results suggest that in response to stretch, MMP-2 responds rapidly by inhibiting conversion of a MMP-2 to the active form, while a slower up-regulation of MMP-9 may play a role in the long-term remodeling of extracellular matrix in response to continuous mechanical loading

15. Downstream molecular target of protein tyrosine phosphatase sigma (PTPsigma) modulation in oligodendrocyte progenitor cells (OPCs) involving upregulation of the protease matrix metallopeptidase 2 (MMP-2) that allows OPCs to enzymatically digest their way through chondroitin sulfate proteoglycans (CSPGs

16. In obese mice, periodontitis caused the downregulation of MMP2, and upregulation of TIMP1 and TGF-beta1 at transcriptional and translational levels.

17. In the initial periods of AP progression, an increased expression of MMP9 in the TLR2 KO and MyD88 KO mice was observed. In the final periods of AP progression, a reduction of MMP2 expression and an increase of MMP9 expression in the TLR2 KO mice were observed. MMP2 and MMP9 production was modulated for TLR2 and MyD88 during apical periodontitis progression

18. MMP-2 promoted and MMP-13 disrupted vasculogenic mimicry formation in large cell lung cancer by cleaving laminin-5 to influence EGFR signal activation.

19. Diet and exercise affect atheromatous MMP2/9 activity by modulating the systemic inflammatory milieu, with sVCAM-1, resistin, and adiponectin closely interacting with each other and with visceral fat.

20. calpains inhibition plays crucial roles in vascular restenosis by preventing neointimal hyperplasia at the early stage via suppression of the MMP2/TGF-beta1 pathway.

Human Matrix Metalloproteinase 2 (MMP2) Interaktionspartner

1. linc00858 acted as a competitive endogenous RNA to sponged miR-3182 and regulate MMP2 in lung cancer

2. These data suggest that upregulation of NaV1.6 channel expression occurs when cervical epithelium have been transformed into cancer cells, and that NaV1.6-mediated invasiveness of cervical cancer cells involves MMP-2 activity.

3. Study demonstrated that eosinophils induce fibroblast-to-myofibroblast transition, secretion of matrix metalloproteinase-2, accelerated migration of fibroblasts, and promote matrix metalloproteinase-2-related airway remodeling.

4. Authors demonstrated that T2E fusion positive ASAP patients with higher MMP-2 expression were more likely to be diagnosed with PC at a subsequent biopsy during the follow-up period (P = 0.003).

5. Data show that myoferlin (MYOF) plays an important role in VM and knockdown of MYOF suppresses vasculogenic mimicry (VM) formation via decreasing matrix metallopeptidase 2 (MMP-2) and inducing mesenchymal-to-epithelial transition (MET) in A375 melanoma cells.

6. this study demonstrates that scleraxis directly transactivates the proximal MMP2 gene promoter, resulting in increased histone acetylation, and identify a specific E-box sequence in the promoter to which scleraxis binds.

7. The coexpression of ACTA2 and DES was related to the expression of MMP2, and positively correlated with lymph node metastasis. Activation of pancreatic stellate cells may promote the expression of MMP2 and enhance the invasion and metastasis of pancreatic carcinoma.

8. Results showed high expression levels of MMP2 or MMP9 in ovarian cancer tissues compared to the adjacent normal ones and positively correlated with TP73-AS1 expression level.

9. The MMP-2 (-1306 C/T) gene polymorphism was found to be associated with Optic Neuritis development.

10. Data show when cells were treated with siRNA-dipeptidyl peptidase 8 (DPP8), the expression of cyclin D1, matrix metalloproteinases, secreted MMP2 and MMP9 was downregulated.

11. This study discovered a feedback loop where sustained activation of P2X7 triggers release of active matrix metalloproteinase 2 (MMP-2), which halts ion channel and large pore responses via the MMP-2-dependent receptor cleavage.

12. ROCK1 and ROCK2 regulated cell proliferation in PC-3 and DU145 prostate cancer cells. Protein levels of phosphorylated LIM kinase 1 (p-LIMK1) and matrix metalloproteinase-2 (MMP-2) were reduced in ROCK1 and ROCK2 siRNA transfected cells. In PC-3 and DU145 human prostate cancer cells, ROCK promoted cell proliferation and migration by targeting LIMK1 and MMP-2.

13. Imbalance in the metalloproteinase (MMP2, MMP9) to inhibitor tissue expression (TIMP1, TIMP2) in the vessel wall (the cross-sections of the internal thoracic artery, radial artery, and saphenous vein) might predispose to aortocoronary graft failure after coronary artery bypass grafting. A stronger expression of TIMPs than MMPs in the arterial grafts might explain favourable long-term outcomes.

14. Increasing urinary cadmium concentrations were positively associated with hypertension risk in a Chinese population, and the associations were modified by polymorphism of rs14070 and rs7201 in gene MMP-2.

15. Results found that MMP-2 was responsible for the Naa10p-induced invasive phenotype of human osteosarcoma cells. Naa10p was directly associated with MMP-2 protein through its acetyltransferase domain maintaining MMP-2 protein stability . MMP-2 expression levels were also significantly correlated with Naa10p levels in osteosarcoma tissues.

16. Mechano-growth factor regulates cyclic stretch-induced osteogenic differentiation and MMP-1, MMP-2 expression in human periodontal ligament cells by activating MEK/ERK1/2 signaling pathway.

17. This study indicated that the MMP-2 (-1306C/T) polymorphism, in combination with the TIMP-2 (-418G/C) polymorphism, contributes to acne vulgaris susceptibility in the Chinese Han population.

18. we compared the expression of MMP1, MMP2, MMP7, and MMP9, well known as secreted MMPs, and found that MMP expression varied in lesions with different histological grade,histological subtype, and type of invasion.

19. TLR4 and MMP2 polymorphisms and their complex interactions with cardiovascular risk factors contributed to aortic aneurysmal diseases.

20. Rg3 suppressed the expression of EMT-related transcription factors, especially the Zinc Finger E-Box Binding Homeobox 1 (ZEB1). In summary, our data suggested that Rg3 could inhibit migration and invasion of NPC cells. This effect of Rg3 might be mediated through regulating MMP-2 and MMP-9 expressions and suppressing EMT.

Cow (Bovine) Matrix Metalloproteinase 2 (MMP2) Interaktionspartner

1. this study shows that differential FFAR1 signaling is associated with gene expression or gelatinase granule release in bovine neutrophils

2. NADPH oxidase plays an important role in proMMP-2 expression and activation and MMP-2 mediated SMC proliferation occurs through the involvement of Spm-Cer-S1P signaling axis under ANG II stimulation of PASMCs

3. The expression patterns of MMP1, MMP2, and MMP8 were explored during fetal and postnatal development of longissimus dorsi muscle in cattle, and the relationships of MMP1, MMP2, and MMP8 expression levels with meat quality traits were analyzed in cattle. The expression of MMP1, MMP2, and MMP8 were also tested in four kinds of fat tissues and three kinds of skeletal muscle tissues.

4. The results showed that a decrease in MMP-1 and MMP-2 gene expression is accompanied with a decrease in NO concentrations in infertile cows affected with ovarian cysts.

5. Activation of cytosolic MMP-9 and MMP-2 was investigated in the retinal endothelial cells incubated in high glucose for 6-96 h, and correlated with their mitochondrial accumulation and mitochondrial damage.

6. Data indicate the involvement of PKC-alpha in proMMP-2 activation and inhibition of TIMP-2 expression by NF-kappaB-MT1-MMP-dependent and -independent pathway.

7. Data suggest that EMMPRIN derived from endometrial epithelial cells regulates expression of matrix metalloproteinases (MMP-2; MMP-14) in endometrial stromal cells; expression of stromal MMPs is significantly higher in coculture with epithelial cells.

8. Adding pure bovine MMP-2 to the smooth muscle membrane suspension causes an increase in Ca(2+)-ATPase activity, but the pretreatment with TIMP-2 inhibits the increase in the enzyme activity

9. A differential pattern of matrix metalloproteinase-2 and Tissue inhibitor metalloproteinase-2 was observed in cow uteri with adenomyosis.

10. MMP-14, MMP-2 and TIMP-2 are co-localized in the fetal compartment and therefore could influence the timely release of fetal membranes in cattle.

11. Results describe distinct changes in expression of MMP2, MMP14, and the metallopeptidase inhibitor TIMP2 between different phases of the estrous cycle indicating an endocrine regulation.

12. EMMPRIN from the luminal epithelium may regulate the expression of stromal MMP-2 and MMP-14 suggesting a role in adhesion and fusion of embryo to luminal epithelium.

13. High shear stress up-regulates type IV collagen synthesis and down-regulates MMP-2 secretion in endothelial cells.

14. increased MMP-2 activity subsequently played a pivotal role in stimulating Ca2+ ATPase activity in bovine pulmonary vascular smooth muscle plasma membrane

15. MMP2 has a role in the oxidant activation of Ca2+Atpase

16. results suggest a significant role of matrix metalloproteinase-2 and-9 in growth and development of bovine follicle

17. Cells constitutively produced proMMP-9 and proMMP-2, and treatment with TNFalpha, hepatocyte growth factor, and 12-O-tetradecanoylphorbol 13-acetate resulted in significant increase in level of proMMP-9 but not in level of proMMP-2.

18. MMP-2 and MMP-9 production in blastocysts attached to the endometrial cells is regulated by TNF-alpha and TNF-beta

19. study suggests that MMP-2 plays an important role in regulating Ca2+ATPase activity, and ATP-dependent and Na+-dependent Ca2+ uptake in microsomes of bovine pulmonary artery smooth muscle during treatment with peroxynitrite

20. reveal a potentially novel role for strain-induced endothelial matrix metalloproteinase-2 in regulating vascular smooth muscle cell migration

Pig (Porcine) Matrix Metalloproteinase 2 (MMP2) Interaktionspartner

1. we demonstrated the presence of high molecular weight (HMW) complexes (130, 170, and 220 kDa) containing MMP9, TIMP1, and NGAL (also MMP2 in 220 kDa complex) without proteolytic activity.

2. Data demonstrate for the first time that MMP2 and MMP9 are expressed in swine ovarian follicle both in theca and granulosa layers.

3. FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 and MMP-2, caspase-3 and BDNF

4. MMP-2 may play an important role in regulating MLC1 turnover in the heart under normal physiological conditions

5. Oxygen for newborn resuscitation increases MMP-2/-9 activity resulting in tissue damage and influencing remodeling processes.

6. PI3K-dependent regulation of MT1-MMP protein synthesis and subsequent activation of latent MMP-2 as critical events in neointimal hyperplasia after vascular injury.

7. MMP-2 processes dental sialophosphoprotein into smaller subunits in the dentin matrix during odontogenesis

8. contribution of MMPs to the inflammatory breakdown of the blood-CSF barrier in vitro

9. The levels of matrix metalloproteinase-2 and matrix metalloproteinase-9 in the corpus luteum of swine during luteolysis are reported.

10. Hemodialysis graft placement leads to early increases in wall shear stress, VEGF-A, pro-MMP-9, MMP-2, VEGFR-1, VEGFR-2, and TIMP-1, which may contribute to the development of venous stenosis.

11. In conclusion, thrombin activates pro-MMP-2 in the absence of elevated pro-MMP-2 expression and secretion in CSMCs, and thrombin induces CSMC mitogenesis involving its action on MMP-2.

12. MMP-2 has a novel function in the degradation of the nuclear matrix in cigarette smoke-induced endothelial apoptosis.

13. we cloned the 5'-upstream sequence, 3'-downstream sequence as well as other missed genomic sequences of porcine MMP-2, the genomic structure and the promotor sequence were analyzed and found to share high similarity with those of human MMP-2.

14. The expression of MMP2 and MMP9 in lung injury induced by mechanical stress, hypoxic injury, and septic shock in anesthetized swine are reported.

15. The association results showed that the animals with the C allele of MMP2 have a significantly larger loin muscle area than that of the animals with the G allele (P < 0.05)

Rabbit Matrix Metalloproteinase 2 (MMP2) Interaktionspartner

1. Modulation of MMP-2 and MMP-9 is critical for extracellular matrix balance of intra-articular ligaments.

2. These results show that MMP-2 activates the EGFR and triggers downstream signaling pathways increasing Reactive Oxygen Species formation and promoting vasoconstriction.

3. The present study demonstrated the ability of 30 and 100 ng/ml TIMP3 to attenuate migration and proliferation, and to inhibit the activity of MMP2, MMP9 and TNFalpha secretion of NA SMCs. In conclusion, TIMP3 may be considered a potential therapeutic drug for use in a novel drugeluting stent, to attenuate the progressive dilation of the aortic NA.

4. Selenium suppressed high-fat diet-induced MMP2 over-expression in vivo by improving lipid metabolism.

5. Repetitive mechanical stimulation of tendon cells results in a small increase in matrix metalloproteinase2 levels, but it appears unlikely that serum matrix metalloproteinase2 will be a useful indicator of tendon overuse injury.

6. Inflammatory factors such as TNF-alpha can stimulate MMP-2/9 activity in corneal epithelium cells. This may be a potential manipulating mechanism of MMP expression in the pathogenesis of corneal diseases

7. Results provide evidence that MMP-2 bears the potentiality to cleave alpha-DG enriched from rabbit skeletal muscle indicating that this degradation indeed might also occur in vivo.

8. These data suggest that OxyHb suppresses K V currents through both reactive oxygen species-dependent and independent pathways involving MMP activation.

9. In conclusion, MMP-2 could be responsible for the proteolysis of dystrophin.

10. Castor oil polymer induces bone formation with high matrix metalloproteinase-2 expression.

11. MMP2 spinal cord expression is increased in cervical spondylotic myelopathy.

12. Ulinastatin effectively inhibited the increased expression of MMP-2, MMP-3, and iNOS in degenerated NP cells induced by IL-1beta in vitro.

13. Hemoperfusion could obviously reduce oxidative stress and the expression levels of MMP-2, MMP-9 and TIMP-1 in rabbits with acute paraquat poisoning.

14. Exposure to long periods of light irrespective of its characteristics leads to the increased expression of some matrix metalloprpteases.

15. The RNA interference targeting COX-2 can effectively inhibit the expression of COX-2 and MMP-2 in IL-1alpha stimulated rabbit corneal stromal cells in vitro.

16. Our results strongly suggest that ischaemic postconditioning may exert part of its cardioprotective effects through the inhibition of MMP-2 activity.