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anti-Human DDX58 Antikörper:
anti-Mouse (Murine) DDX58 Antikörper:
anti-Rat (Rattus) DDX58 Antikörper:
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Human Polyclonal DDX58 Primary Antibody für WB - ABIN388602
Bao, Liu, Shan, Li, Garofalo, Casola: Human metapneumovirus glycoprotein G inhibits innate immune responses. in PLoS pathogens 2008
Show all 9 Pubmed References
Human Polyclonal DDX58 Primary Antibody für IHC - ABIN965986
Imaizumi, Aratani, Nakajima, Carlson, Matsumiya, Tanji, Ookawa, Yoshida, Tsuchida, McIntyre, Prescott, Zimmerman, Satoh: Retinoic acid-inducible gene-I is induced in endothelial cells by LPS and regulates expression of COX-2. in Biochemical and biophysical research communications 2002
Show all 8 Pubmed References
Human Polyclonal DDX58 Primary Antibody für IHC - ABIN965987
Cui, Imaizumi, Yoshida, Borden, Satoh: Retinoic acid-inducible gene-I is induced by interferon-gamma and regulates the expression of interferon-gamma stimulated gene 15 in MCF-7 cells. in Biochemistry and cell biology = Biochimie et biologie cellulaire 2004
Show all 6 Pubmed References
Human Polyclonal DDX58 Primary Antibody für IHC - ABIN965985
Yoneyama, Kikuchi, Natsukawa, Shinobu, Imaizumi, Miyagishi, Taira, Akira, Fujita: The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. in Nature immunology 2004
Show all 6 Pubmed References
Human Monoclonal DDX58 Primary Antibody für IP, IHC - ABIN1169336
Gack, Nistal-Villán, Inn, García-Sastre, Jung: Phosphorylation-mediated negative regulation of RIG-I antiviral activity. in Journal of virology 2010
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Human Polyclonal DDX58 Primary Antibody für IHC (p), WB - ABIN2476365
Chapuis, Knobel, Loup, von Niederhäusern: [Isolated renal angiomyolipoma]. in Helvetica chirurgica acta 1976
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Human Polyclonal DDX58 Primary Antibody für IHC, ELISA - ABIN1003083
Alexopoulou, Holt, Medzhitov, Flavell: Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. in Nature 2001
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Human Monoclonal DDX58 Primary Antibody für IHC, IHC (p) - ABIN4350538
Pei, Deng, Ye, Wang, Gou, Liu, Zhao, Liao, Yi, Chen: Absence of autophagy promotes apoptosis by modulating the ROS-dependent RLR signaling pathway in classical swine fever virus-infected cells. in Autophagy 2016
Show all 2 Pubmed References
Human Polyclonal DDX58 Primary Antibody für IHC (p), WB - ABIN4350540
Seki, Yoshizumi, Tanaka, Ryo, Ishioka, Tsukagoshi, Kozawa, Okayama, Okabe-Kado, Goya, Kimura: Cytokine profiles, signalling pathways and effects of fluticasone propionate in respiratory syncytial virus-infected human foetal lung fibroblasts. in Cell biology international 2014
Human Polyclonal DDX58 Primary Antibody für ELISA, IHC - ABIN4350536
Zhu, Duan, Wang, Cao, Liu: TREM-1 activation modulates dsRNA induced antiviral immunity with specific enhancement of MAPK signaling and the RLRs and TLRs on macrophages. in Experimental cell research 2016
RIG-I-like receptors (RLRs) are well-known viral RNA sensors in the cytoplasm that recognize the nonself signatures of viral RNAs to trigger IFN responses.
Knockdown of PBRM1 (zeige PBRM1 Antikörper) in colon cancer cells increased the expression of two receptor genes (RIG-I and MDA5 (zeige IFIH1 Antikörper)) and upregulated interferon (zeige IFNA Antikörper) (IFN)-related and inflammation-related gene signatures.
Dengue virus infection of human dendritic cells drives follicular T helper cells formation via crosstalk of RIG-I and MDA5 (zeige IFIH1 Antikörper).
DDX58_rs10813831 T-allele may be associated with a reduced risk of nodular sclerosis EBV-related cHL (zeige CHRDL1 Antikörper), which suggests a role for RIG-I (retinoic acid-inducible gene I), encoded by DDX58, in these cases.
mutations in the genes encoding for RIG-I and MDA5 (zeige IFIH1 Antikörper) have been identified to cause rare diseases including Aicardi-Goutieres syndrome, Systemic Lupus Erythematosus in certain individuals as well as classic and atypical Singleton-Merten syndrome. Patients carrying mono-allelic mutations in MDA5 (zeige IFIH1 Antikörper) and RIG-I show constitutive activation of the RIG-I receptors and downstream signalling
These findings demonstrate how IFNgamma induced CK2 (zeige CSNK2A1 Antikörper) regulates RIG-I to drive a complex program of metabolic adaptation and redox homeostasis, crucial for determining glioma cell fate.
IFNgamma induced PPAR gamma coactivator-1 alpha (PGC-1alpha) positively regulated RIG-I; with PRMT-1 and G9a affecting PGC-1alpha in a counter-regulatory manner.
Data show that host-derived RNAs, most prominently 5S ribosomal RNA pseudogene 141 (RNA5SP141), bound to RIG-I during infection with herpes simplex virus 1 (HSV-1).
RIG-I expression is markedly increased in the affected skin derived from psoriasis patients and from both IL-23 (zeige IL23A Antikörper)- and imiquimod -induced psoriasis-like mouse model.
DDX58 was confirmed to be the downstream target of TRIM24 (zeige TRIM24 Antikörper), whose downregulation is essential for the migratory phenotype induced by GLUT4 (zeige SLC2A4 Antikörper)-TRIM24 (zeige TRIM24 Antikörper) activation in head and neck squamous cell carcinoma cells.
RNF122 (zeige RNF122 Antikörper) suppresses antiviral type I interferon (zeige IFNA Antikörper) production by targeting RIG-I caspase (zeige CASP3 Antikörper) activation and recruitment domains to mediate RIG-I degradation.
innate immune signaling mediated by RLR (zeige DHX58 Antikörper) plays a critical role in nuclear reprogramming.
Toll-like receptor 2 (TLR2) and retinoic acid-inducible gene I (RIG-I) cooperatively initiate innate immune responses to MuV infection in mouse ovarian granulosa cells.
Collectively, these results uncover an independent functional contribution of the apo (zeige C9orf3 Antikörper)-Rig-I/Stat3 (zeige STAT3 Antikörper) interaction in the maintenance of Treg/Th17 cell balance.
The RIG-I, as well as the adaptor protein mitochondrial antiviral signaling protein (zeige MAVS Antikörper), regulates NF-kappaB (zeige NFKB1 Antikörper)-mediated induction of adhesion molecules and proinflammatory cytokine expression in response to LPS (zeige TLR4 Antikörper).
Data suggest that activation of either RIG-I/MAVS (zeige MAVS Antikörper) or STING pathways during acute intestinal tissue injury in mice resulted in IFN-I signaling that maintained gut (zeige GUSB Antikörper) epithelial barrier integrity and reduced GVHD severity.
RIG-I subsequently localized to antiviral stress granules induced after viral replication complexes formation
identifies DDX58 and MTHFSD as two TDP-43 (zeige TARDBP Antikörper) targets that are misregulated in amyotrophic lateral sclerosis. 1
Data show that preconditioning with poly(I:C) alters toll (zeige TLR4 Antikörper)-like receptors (TLR) and RIG-I-like receptors (RLRs) responses in opposite directions.
Viral RNA polymerase components PB2, PB1, and PA directly target RIG-I.
These data indicate that classical swine fever virus can be recognized by both RIG-I and MDA5 (zeige IFIH1 Antikörper) to initiate the RIG-I signaling pathway to trigger innate defenses against infection.
DDX58 had two nonsynonymous SNPs in the helicase (zeige DNA2 Antikörper) domain.
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of immune response.
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide RIG-I
, probable ATP-dependent RNA helicase DDX58
, putative ATP-dependent RNA helicase DDX58
, retinoic acid-inducible protein I
, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
, probable ATP-dependent RNA helicase DDX58-like
, DEAD box protein 58
, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide
, RIG-I-like receptor 1
, RNA helicase RIG-I
, retinoic acid inducible gene I
, retinoic acid-inducible gene 1 protein
, retinoic acid-inducible gene I protein
, DEAD-box protein 58
, DEAD/H box polypeptide RIG-I
, retinoic acid-inducible gene-I
, RNA helicase induced by virus