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rs17684886 (ZNRF1 (zeige ZNRF1 Proteine)) and rs599019 (COLEC12) are associated with diabetic retinopathy and rs6427247 (SCYL1BP1 (zeige GORAB Proteine)) and rs899036 (API5 (zeige API5 Proteine)) are associated with severe diabetic retinopathy in Chinese patients with type 2 diabetes
The common presence of Lewis(x (zeige FUT4 Proteine)) groups in granule protein glycans can thus target granule proteins for clearance by SRCL.
The Le(x) residues of both, CEACAM1 (zeige CEACAM1 Proteine) and CEA (zeige CEACAM5 Proteine), interact with the human Le(x)-binding glycan receptors DC-SIGN (zeige CD209 Proteine) and SRCL.
haplotype structure of the CL-P1 gene obtained from six single-nucleotide polymorphisms that were genotyped with 108 alleles in Japanese subjects
SRCL is expressed in some but not all nurse-like cells; its C-type lectin (zeige MBL2 Proteine) domain binds specifically to several carbohydrates including GalNAc, T and Tn antigen in a Ca2 (zeige CA2 Proteine)+-dependent manner.
SRCL might be involved in selective clearance of specific desialylated glycoproteins from circulation and/or interaction of cells bearing Lewis(x (zeige FUT4 Proteine))-type structures with the vascular endothelium
CL-P1 is not a common membrane protein on endothelial cells found in normal tissues under steady state conditions.
CL-P1 predominantly mediated phagocytosis for fungi in vascular endothelia.
Structural analysis of carbohydrate-recognition domain of SRCL in complex with Lewis(x (zeige FUT4 Proteine)) and mutagenesis show the basis for this specificity, which is analogous to how selectins and DC-SIGN (zeige CD209 Proteine) bind to related fucosylated glycans [scavenger receptor C]
This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor, a cell surface glycoprotein that displays several functions associated with host defense. It can bind to carbohydrate antigens on microorganisms, facilitating their recognition and removal. It also mediates the recognition, internalization, and degradation of oxidatively modified low density lipoprotein by vascular endothelial cells.
collectin sub-family member 12
, collectin placenta protein 1
, nurse cell scavenger receptor 2
, scavenger receptor class A, member 4
, scavenger receptor with C-type lectin
, collectin 1 precursor CL-3