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CD109 knockdown upregulated IL-8 (zeige IL8 ELISA Kits) expression through activation of TGF-beta (zeige TGFB1 ELISA Kits)/Akt (zeige AKT1 ELISA Kits)/NF-kappaB (zeige NFKB1 ELISA Kits) pathway in human umbilical vein endothelial cells
High expression of CD109 in brain tumor stem cells is involved in glioma progression.
The CD109 protein was up-regulated in hepatocellular carcinoma tissue compared with adjacent noncancerous tissue. CD109 shRNA knockdown delayed the G1-S phase transition, abrogated cell proliferation, and increased cell apoptosis. Furthermore, CD109 impaired TGF-beta (zeige TGFB1 ELISA Kits)/Smad (zeige SMAD1 ELISA Kits) signaling through control of p-smad2 (zeige SMAD2 ELISA Kits).
CD109 is a putative biomarker for identifying a high-risk group among DLBCL patients.
The most common HPA (zeige HPSE ELISA Kits) genotypes among Saudis were HPA-1 (zeige HPSE ELISA Kits) a + b- (75%), HPA-2 (zeige HPSE2 ELISA Kits) a + b- (62%), HPA-3 a + b- (51.5%), HPA (zeige HPSE ELISA Kits)-4 a + b- (99%), HPA-5 (zeige ITGA2 ELISA Kits) a + b- (76.5%), HPA (zeige HPSE ELISA Kits)-6 a + b- (100%) and HPA (zeige HPSE ELISA Kits)-15 a + b + (50%). The prevalent allele among the HPA (zeige HPSE ELISA Kits) systems was (a), except in the HPA (zeige HPSE ELISA Kits)-15 system where the (b) allele was found in 52% of the subjects.
Expression levels of CD109 was reduced significantly in psoriasis. Lower expression of CD109 and TGF-beta (zeige TGFB1 ELISA Kits) RI was highly correlated with higher expression of Smad7 (zeige SMAD7 ELISA Kits) and Ki67 (zeige MKI67 ELISA Kits), suggesting that CD109 may induce the pathogenesis of psoriasis through Smad7 (zeige SMAD7 ELISA Kits)-mediated degradation of TGF-beta (zeige TGFB1 ELISA Kits) RI.
sCD109 can bind TGF-beta (zeige TGFB1 ELISA Kits), inhibit TGF-beta (zeige TGFB1 ELISA Kits) binding to its receptors and decrease TGF-beta (zeige TGFB1 ELISA Kits) signalling and TGF-beta (zeige TGFB1 ELISA Kits)-induced cellular responses.
These findings indicate that CD109 is an exosomal protein and that the C-terminal region of CD109 is required for its presence in the exosome.
CD109 may be a potential pathology marker for gallbladder squamous cell/adenosquamous carcinomas.
CD109 is specifically expressed in endothelial cells of cutaneous cavernous haemangioma.
platelet and endothelial GARP (zeige LRRC32 ELISA Kits) are not important in hemostasis and thrombosis in mice
Small-scale in vivo screening identified several genes, including Cd109, that encode novel pro-metastatic factors. We uncovered signaling mediated by Janus kinases (Jaks) and the transcription factor Stat3 (zeige STAT3 ELISA Kits) as a critical, pharmacologically targetable effector of CD109-driven lung cancer metastasis
CD109 differentially regulates TGF-beta (zeige TGFB1 ELISA Kits)-induced ALK1 (zeige ACVRL1 ELISA Kits)-Smad1 (zeige SMAD1 ELISA Kits)/5 versus ALK5 (zeige TGFBR1 ELISA Kits)-Smad2 (zeige SMAD2 ELISA Kits)/3 pathways, leading to decreased extracellular matrix production in the skin; epidermal CD109 expression regulates dermal function through a paracrine mechanism
the GARP (zeige LRRC32 ELISA Kits)/LTGF-beta1 complex on Treg cells is a major source of TGF-beta1 (zeige TGFB1 ELISA Kits) needed for induction of pTreg cells during the process of oral tolerance.
GP96 (zeige HSP90B1 ELISA Kits) serves as an essential chaperone for the cell-surface protein (zeige CD28 ELISA Kits) glycoprotein A repetitions predominant (GARP (zeige LRRC32 ELISA Kits)), which is a docking receptor for latent membrane-associated TGF-beta (zeige TGFB1 ELISA Kits) (mLTGF-beta).
CD109 decreases extracellular matrix production and fibrotic responses during hypoxic wound healing
CD109 is present in serum as a soluble form, and suggest its potential as a novel tumor marker in patients with cancers that express CD109.
CD109 might be an important regulator of osteoclastogenesis.
findings demonstrate that CD109 overexpression in the epidermis reduces inflammation and granulation tissue area and improves collagen organization in vivo.
This gene encodes a member of the alpha2-macroglobulin/complement superfamily. The encoded GPI-linked glycoprotein is found on the cell surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signaling of transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene.
150 kDa TGF-beta-1-binding protein
, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7
, CD109 antigen
, Gov platelet alloantigens
, activated T-cell marker CD109
, platelet-specific Gov antigen
, CD109 molecule
, CD109 antigen-like
, GPI-anchored alpha 2 macroglobulin-related protein
, GPI-anchored alpha-2 macroglobulin-related protein