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anti-Human NR3C2 Antikörper:
anti-Rat (Rattus) NR3C2 Antikörper:
anti-Mouse (Murine) NR3C2 Antikörper:
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Human Polyclonal NR3C2 Primary Antibody für IF (p), IHC (p) - ABIN735353
Liu, Jiang, Zhang, Li, Li, Xie, Hu: Pulmonary artery denervation improves pulmonary arterial hypertension induced right ventricular dysfunction by modulating the local renin-angiotensin-aldosterone system. in BMC cardiovascular disorders 2016
Data demonstrate that there are distinct differences between the human mineralocorticoid receptor (MR) and the zebrafish MR despite considerable sequence and functional conservation.
Corticosterone coordinates via mineralocorticoid receptor the networks underlying how an individual copes with stress, and this action is complemented by the widely distributed lower affinity glucocorticoid receptor (zeige NR3C1 Antikörper) involved in the subsequent management of stress adaptation.
SUMOylation of 11beta-HSD2 (zeige HSD11B2 Antikörper) at residue K266 modulates cortisol-mediated MR nuclear translocation independently of effects on transactivation.
haplotype TAAT of GR might be a protective factor against aggressive behavior, while gene-gene interactions between GR (NR3C1 (zeige NR3C1 Antikörper)) rs1800445 and MR (NR3C2) rs2070951 might be a risk factor for aggressive behavior in the Central South Chinese Han population
Polymorphisms of the glucocorticoid receptor (zeige NR3C1 Antikörper) gene influenced both the basal state of the hypothalamus-pituitary-adrenal axis as well as self-perceived stress. The mineralocorticoid receptor gene only associated with self-perceived stress and 5-HTT (zeige SLC6A4 Antikörper) only with the cortisol awakening response.
Low NR3C2 expression is associated with Pancreatic Cancer.
the variant rs2070951 and the GA haplotype in NR3C2 were associated with an increased risk for cCSC. Results of this genetic study support a possible role for the mineralocorticoid receptor in the pathogenesis of cCSC.
Glucocorticoid receptor (GR (zeige NR3C1 Antikörper)) and Mineralocorticoid Receptor (MR) actions on NFkappaB (zeige NFKB1 Antikörper) - and AP-1 (zeige FOSB Antikörper)-dependent signaling were compared in a standardized cellular context where GR or MR could be specifically expressed in the absence of other nuclear receptors. Like GR, MR was found to repress NFkappaB (zeige NFKB1 Antikörper)-driven transcription in these cells.
The new frameshift mutation decreased the expression of MR, but not NR3C2 mRNA, and led to decreased MR function, with no dominant negative effect.
dysregulation of GR, MR, FKBP5 (zeige FKBP5 Antikörper), and PTGES3 (zeige PTGES3 Antikörper) in autistic spectrum disorder (ASD (zeige ARSD Antikörper)) and suggest a possible role of inflammation in altered GR function in ASD (zeige ARSD Antikörper).
hyperactive hypothalamo-pituitary-adrenocortical axis in overweight diabetic subjects may be associated with downregulation of 11beta-HSD1 (zeige HSD11B1 Antikörper), MR, and GR in the brain.
Endothelial mineralocorticoid receptor contributes to the transition of cardiac hypertrophy to systolic dysfunction.
myeloid MR knockout (MRKO) improves glucose intolerance, insulin (zeige INS Antikörper) resistance, and hepatic steatosis in obese mice. Estrogen signaling is sufficient and necessary for such improvements. Hepatic gene and protein expression suggests that MRKO reduces hepatic lipogenesis and lipid storage.
Nr3c2 has a role in mouse skin development in a process that involves HSD11B1 (zeige HSD11B1 Antikörper)/HSD11B2 (zeige HSD11B2 Antikörper)
Inducible Knock-Down of the Mineralocorticoid Receptor in Mice Disturbs Regulation of the Renin (zeige REN Antikörper)-Angiotensin-Aldosterone System and Attenuates Heart Failure Induced by Pressure Overload
Data indicate that endothelial cell mineralocorticoid receptor (MR) deficiency prevented Western diet (WD)-induced diastolic dysfunction, profibrotic, and progrowth signaling.
Cardiomyocyte mineralocorticoid receptor activation impairs acute cardiac functional recovery after ischemic insult.
a cooperative role of MR and cav-1 (zeige CAV1 Antikörper) in regulating vascular contraction and NO-cGMP-mediated relaxation during low NO-high AngII-dependent cardiovascular injury
Upregulation of MR in mouse adipocytes led to increased weight and fat mass, insulin (zeige INS Antikörper) resistance, and metabolic syndrome features without affecting blood pressure.
Data showed that the mRNA expression of glucocorticoid and mineralocorticoid receptors were significantly decreased in splenic macrophages by repeated social defeat. Epigenetic regulation, may play a role in the RSD-induced GC resistance.
Compared to sham-mice, the expression levels of hypothalamic MR, serum glucocorticoid-induced kinase 1 (a marker of MR activity) and AT1R (zeige AGTRAP Antikörper) increased in pressure-overload-mice.
This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.
, nuclear receptor subfamily 3, group C, member 2
, nuclear receptor subfamily 3 group C member 2
, aldosterone receptor
, mineralocorticoid receptor 1
, mineralocorticoid receptor delta
, Mineralocorticoid receptor (aldosterone receptor)