IL-36Ra (human) Matched Pair Detection Set

Produktnummer ABIN2745406

Produktdetails

Target: FIL1d (Interleukin 1 delta (FIL1d))

Nachweismethode: Colorimetric

Methodentyp: Sandwich ELISA

Detektionsbereich: 0.78-50 ng/mL

Untere Nachweisgrenze: 0.78 ng/mL

Applikation: ELISA

Proben: Cell Culture Supernatant

Spezifität: Detects human IL-36Ra.

Kreuzreaktivität: Human

Sensitivität: 0.5 ng/mL

Bestandteile: 1 vial standard protein (1μg) (lyophilized) [STD] 1 vial coating antibody (270μl) [COAT] 1 vial detection antibody (120μl) [DET] 1 vial streptavidin-HRP (10μg) (lyophilized) [STREP]

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: -20 °C

Informationen zur Lagerung: Short Term Storage: -20°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Haltbarkeit: 12 months

Antigendetails

Target: FIL1d (Interleukin 1 delta (FIL1d))

Andere Bezeichnung: IL-36Ra (FIL1d Produkte)

Hintergrund: IL-36Ra/IL-1F5 is a highly and specific antagonist of the IL-1 receptor-related protein 2-mediated response to IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9). These cytokines bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. Recently mutations that affect the levels and the activity of IL-36Ra have been found in patients with pustular psoriasis, leading to enhanced production of inflammatory cytokines (IL-8 in particular) by keratinocytes.

UniProt: Q9UHA7