ShK

Produktnummer ABIN1540127

Kurzübersicht für ShK (ABIN1540127)

Target: Toxin ShK (Stoichactishelianthus potassium-channel reduced)

Applikation: Blocking Reagent (BR)

Produktdetails

Verwendungszweck: ShK is a Kv1.3 channel selective blocker

Sequenz: Arg-Ser-Cys3-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys12-Thr-Ala-Phe-Gln-Cys17-Lys-His-Ser-Met-Lys-Tyr-Arg-Leu-Ser-Phe-Cys28-Arg-Lys-Thr-Cys32-Gly-Thr-Cys35-OHDisulfid e bonds between Cys3-Cys35, Cys12-Cys28 and Cys17-Cys32

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Antigendetails

Target: Toxin ShK (Stoichactishelianthus potassium-channel reduced)

Hintergrund: ShK has been isolated from the venom of the Carribean seaanemone Stoichactis helianthus. This toxin inhibits voltagedependentpotassium channels. It blocks Kv1.3 (KCNA3)potently and also Kv1.1 (KCNA1), Kv1.4 (KCNA4), and Kv1.6(KCNA6) respectively with 11 pM,16 pM and 165 pM.

Molekulargewicht: 4054.85 Da