Chlorotoxin

Produktnummer ABIN1540033

Produktdetails

Target: Chlorotoxin

Applikation: Blocking Reagent (BR)

Verwendungszweck: Chlorotoxin is supposed to inhibit chloride channels

Sequenz: Met-Cys2-Met-Pro-Cys5-Phe-Thr-Thr-Asp-His-Gln-Met-Ala-Arg-Lys-Cys16-Asp-Asp-Cys19-Cys20-Gly-Gly-Lys-Gly-Arg-Gly-Lys-Cys28-Tyr-Gly-Pro-Gln-Cys33-Leu-Cys35-Arg-NH2Disulfide bonds between Cys2-Cys19, Cys5-Cys28,Cys16-Cys33 and Cys20-Cys35

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Antigendetails

Target: Chlorotoxin

Hintergrund: Chlorotoxin is a neurotoxin that was originally isolated from the venom of Leiurus quinquestriatus. Chlorotoxin binds to Cl-channels (small conductance epithelial chloride channels) in the brain and spinal cord and inhibits Cl- influx. Chlorotoxin most probably acts as a specific blocker, although residues both inside and outside of the pore region of the Cl- channels participate in chlorotoxin binding.

Molekulargewicht: 3995.8 Da

CAS-Nummer: 163515-35-3