Apamin

Produktnummer ABIN1540024

Kurzübersicht für Apamin (ABIN1540024)

Target: Apamin

Applikation: Blocking Reagent (BR)

Produktdetails

Verwendungszweck: Apamin is a SK channel inhibitor

Sequenz: Cys1-Asn-Cys3-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys11-Ala-Arg-Arg-Cys15-Gln-Gln-His-NH2Disulfide bonds between Cys1-Cys11 and Cys3-Cys15

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Antigendetails

Target: Apamin

Hintergrund: Apamin is a neurotoxin that was originally isolated from Apis mellifera. Apamin binds to and inhibits the SK channels (small conductance Ca2+-activated K+ channels) in the brain and spinal cord. It inhibits three subtypes of SK channels (SK1, SK2, and SK3) with different affinity. Apamin most likely acts as a pore blocker, although residues both inside and outside of the pore region of the SK channels participate in0 apamin binding. The SK channels are present in a wide range of excitable and non-excitable cells, including cells in the central nervous system, intestinal myocytes, endothelial cells, and hepatocytes.

Molekulargewicht: 2027.34 Da

CAS-Nummer: 24345-16-2