Garcinol

Produktnummer ABIN1439973

Kurzübersicht für Garcinol (ABIN1439973)

Applikation: Blocking Antibody (Inhibition)

Produktdetails

Produktmerkmale: Potent histone acetyltransferases inhibitor
Induces HeLa cell apoptosis
Anti-inflammatory and anti-carcinogenic

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C

Antigendetails

Hintergrund: Garcinol is an inhibitor of the histone acetyltransferases (HATs) p300 and PCAF with IC50 of 7 and 5 uM, respectively. It also inhibits the HAT GCN5 in Cryptococcus neoformans, inducing temperature sensitivity and impairing growth. A polyisoprenylated benzophenone isolated from Garcinia indica, garcinol promotes neurogenesis and ex vivo expansion of human hematopoietic stem cells. It induces apoptosis in several types of cancer cells and has anti-inflammatory actions.

CAS-Nummer: 78824-30-3