Epothilone B

Produktnummer ABIN1027817

Kurzübersicht für Epothilone B (ABIN1027817)

Produktdetails

Verwendungszweck: Microtubule stabilizer

Produktmerkmale: Microtubule stabilizing agent.

Reinheit: >98 %

Chemical Name: (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)-1-propen-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione, Patupilone

Formel: C27H41NO6S

Löslichkeit: Soluble to 10 mM in DMSO

Anwendungsinformationen

Kommentare:

Source: Synthetic.
Appearance: White Solid

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Solid

Vorsichtsmaßnahmen: Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection

Handhabung: Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection

Lagerung: -20 °C

Antigendetails

Hintergrund: Epothilone are a new class of cancer drugs. They prevent cancer cells from dividing by interfering with tubulin. Epithilone B possess the same biological effects as paclitaxel in both invitro and cultured cells, because they share the same binding site. Epothilone has also been shown to induce tubulin polymerization into microtubules without the presence of GTP. And it also causes cell cycle arrest at the G2-M transition phase, leading to eventual cell apoptosis.

Molekulargewicht: 507.68

CAS-Nummer: 152044-54-7