tyrosylprotein Sulfotransferase 2 Proteine (TPST2)

The protein encoded by TPST2 catalyzes the O-sulfation of tyrosine residues within acidic regions of proteins. Zusätzlich bieten wir Ihnen TPST2 Antikörper (77) und TPST2 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TPST2 22022  
TPST2 8459 O60704
Ratte TPST2 TPST2 288719 Q5RJS8
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Showing 7 out of 11 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg 50 bis 55 Tage
$5,262.31
Details
Baculovirus infected Insect Cells Human His tag 50 μg 13 bis 16 Tage
$553.85
Details
Escherichia coli (E. coli) Human His tag 50 μg 13 bis 16 Tage
$553.85
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Details
Hefe Cynomolgus His tag   1 mg 60 bis 71 Tage
$3,036.00
Details
Hefe Rind (Kuh) His tag   1 mg 60 bis 71 Tage
$3,036.00
Details

TPST2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)
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Human , , ,
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Weitere Proteine zu tyrosylprotein Sulfotransferase 2 (TPST2) Interaktionspartnern

Mouse (Murine) tyrosylprotein Sulfotransferase 2 (TPST2) Interaktionspartner

  1. cerebral abnormalities in grt/grt Tpst2 gene defect mice are characterized by cortical hypoplasia at the frontooccipital axis with immature pyramidal neurons and insufficient development of callosal fibers

  2. Findings indicate that low body weight and salivary gland hypofunction in Tpst2-/- mice is due solely to primary hypothyroidism.

  3. Results demonstrate the importance of protein-tyrosine sulfation for proper development of the retina and suggest different phenotypes resulting from elimination of TPST-1 or -2 may reflect differential expression patterns or levels of the enzymes.

  4. Data show that Tpst1/Tpst2 DKO leukocytes bound less P-selectin than wild type leukocytes despite equivalent surface expression of Psgl-1.

  5. Lack of tyrosylprotein sulfotransferase-2 activity results in altered sperm-egg interactions and loss of ADAM3 and ADAM6 in epididymal sperm.

  6. These results indicate that protein-tyrosine sulfation by Tpst1/2 is essential for proper outer segment morphogenesis and synaptic function, but is not critical for overall retinal structure or synapse formation.

  7. demonstrated that the Tpst2 transgene rescues the mutant phenotypes both in vitro and in vivo

  8. Considering that Tpst2 is the responsible gene of grt mice, mutation of which is associated with a poor function of TSH receptor, the findings raise the possibility of involvement of factors including Tpst2 in the insulin hyposecretion in grt mice.

  9. results demonstrate conclusively that TPST-1 and TPST-2 have distinct biological roels in vivo and document for the first time the critical importance of protein-tyrosine O-sulfation in male fertility

  10. The growth-retarded (grt) mutation leads to a loss of TPST2 activity, and TPST2 isoform has a high degree of substrate preference for TSH receptor (TSHR).

  11. Tpst1 and Tpst2 are the only Tpst genes in mice, tyrosine sulfation is required for normal pulmonary function at birth, and TPST-2 is required for normal thyroid gland function.

  12. demonstrate that RNase 9 and Mfge8 are tyrosine-sulfated in wild type and Tpst1(-/-), but not in Tpst2(-/-) mice. This suggests lack of sulfation of one or both of these proteins may contribute mechanistically to the infertility of Tpst2(-/-) males

Human tyrosylprotein Sulfotransferase 2 (TPST2) Interaktionspartner

  1. Using a quantum mechanics protocol of alanine scanning, the study identified unequivocally the role of the amino acids involved in the TPST-2 catalytic mechanism.

  2. the first crystal structure of the human tyrosylprotein sulfotransferase isoform 2 complexed with a substrate peptide (C4P5Y3) derived from complement C4 and 3'-phosphoadenosine-5'-phosphate at 1.9 A resolution, is reported.

  3. The p.R153H variant was found in a family with hereditary pancreatitis; however, it did not segregate with the disease.

  4. Shear stress-dependent upregulation of TPST2 in human endothelium is mediated by a tyrosine kinase-dependent pathway

  5. Tyrosine sulfation of CCR5 N-terminal peptide follows a discrete pattern and temporal sequence

  6. The kinetic parameters of tyrosylprotein sulfotransferase-1 and -2, catalyzing tyrosine sulfation of CCR8 peptides, were determined using liquid chromatography electrospray ionisation mass spectrometry.

Cow (Bovine) tyrosylprotein Sulfotransferase 2 (TPST2) Interaktionspartner

  1. TPSP1 and TPSP2 provide an important posttranslational modification for vision.

TPST2 Protein Überblick

Protein Überblick

The protein encoded by this gene catalyzes the O-sulfation of tyrosine residues within acidic regions of proteins. The encoded protein is a type II integral membrane protein found in the Golgi body. Two transcript variants encoding the same protein have been found for this gene.

Genbezeichner und Symbole assoziert mit TPST2

  • tyrosylprotein sulfotransferase 2 (tpst2)
  • tyrosylprotein sulfotransferase 2 (TPST2)
  • tyrosylprotein sulfotransferase 2 L homeolog (tpst2.L)
  • protein-tyrosine sulfotransferase 2 (Tpst2)
  • tyrosylprotein sulfotransferase 2 (Tpst2)
  • AI448750 Protein
  • D5Ucla3 Protein
  • grm Protein
  • grt Protein
  • TANGO13B Protein
  • zgc:64196 Protein

Bezeichner auf Proteinebene für TPST2

protein-tyrosine sulfotransferase 2 , tyrosylprotein sulfotransferase 2 , TPST-2 , tyrosylprotein sulfotransferase-2 , transport and golgi organization 13 homolog B , tyrosylprotein phosphotransferase 2

GENE ID SPEZIES
393391 Danio rerio
458726 Pan troglodytes
495291 Xenopus laevis
549785 Xenopus (Silurana) tropicalis
100606069 Nomascus leucogenys
100224714 Taeniopygia guttata
100338693 Oryctolagus cuniculus
22022 Mus musculus
8459 Homo sapiens
288719 Rattus norvegicus
540183 Bos taurus
416910 Gallus gallus
486332 Canis lupus familiaris
100154448 Sus scrofa
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