tyrosine Kinase, Non-Receptor, 2 Proteine (TNK2)

This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.

• tyrosine kinase non receptor 2 (TNK2)
• tyrosine kinase, non-receptor, 2 (Tnk2)
• tyrosine kinase non receptor 2 (Tnk2)

• Ack Protein
• ACK-1 Protein
• ACK1 Protein
• AW552477 Protein
• Cdgip Protein
• Alle Synonyme
• p21cdc42Hs Protein
• Pyk1 Protein

activated CDC42 kinase 1 , activated Cdc42-associated kinase 1 , activated p21cdc42Hs kinase , tyrosine kinase non-receptor protein 2 , ACK-1 , Cdc42 GTPase-inhibiting protein , P21cdc42Hs kinase , non-receptor protein tyrosine kinase ACK , activated CDC42 kinase 2