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TNK2 encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. Zusätzlich bieten wir Ihnen tyrosine Kinase, Non-Receptor, 2 Antikörper (222) und tyrosine Kinase, Non-Receptor, 2 Kits (32) und viele weitere Produktgruppen zu diesem Protein an.
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HSP90 (zeige HSP90 Proteine) is an upstream regulator of the ACK1-dependent phosphorylation of STAT1 (zeige STAT1 Proteine) and STAT3 (zeige STAT3 Proteine).
we demonstrate that amplification of ACK1 promotes gastric tumorigenesis by inducing an ECD (zeige SHFM1 Proteine)-dependent ubiquitination degradation of p53 (zeige TP53 Proteine)
These findings suggest that ACK adopts a dock and coalesce binding mechanism with Cdc42. In contrast to other CRIB-family effectors and indeed other intrinsically disordered proteins, hydrophobic residues likely drive Cdc42-ACK binding.
miR (zeige MLXIP Proteine)-24 represses metastasis of human osteosarcoma cells by targeting Ack1 v (zeige AKT1 Proteine)ia AK (zeige MMP2 Proteine)T-MMP (zeige MMP9 Proteine)2-MMP9 pathway.
findings identify ACK1 as a novel SLP-76 (zeige LCP2 Proteine)-associated protein-tyrosine kinase (zeige EPHA8 Proteine) that modulates early activation events in T cells.
ACK1 protein is increased extensively in colitis and colorectal dysplasia. ACK1 overexpression may play a role in colorectal inflammation and neoplasms.
Ack1 overexpression promotes metastasis in hepatocellular carcinoma.
Results found that the expression of ACK1 was significantly up-regulated in non-small-cell lung cancer (NSCLC) samples and demonstrate that ACK1 played an oncogenic role in the progression of NSCLC.
Authors identified tyrosine kinase (zeige TXK Proteine) nonreceptor 2 (TNK2) point mutations that exhibited oncogenic capacity.
that the cdc42 (zeige CDC42 Proteine)-activated, nonreceptor tyrosine kinase (zeige TXK Proteine), Ack1, is a DAT (zeige SLC6A3 Proteine) endocytic brake that stabilizes DAT (zeige SLC6A3 Proteine) at the plasma membrane.
miR (zeige MLXIP Proteine)-24 represses metastasis of osteosarcoma cells by targeting Ack1 via AKT (zeige AKT1 Proteine)-MMP2 (zeige MMP2 Proteine)-MMP9 (zeige MMP9 Proteine) pathway.
findings identify ACK1 as a novel SLP-76 (zeige LCP2 Proteine)-associated protein-tyrosine kinase (zeige YES1 Proteine) that modulates early activation events in T cells.
that the cdc42 (zeige CDC42 Proteine)-activated, nonreceptor tyrosine kinase (zeige TYRO3 Proteine), Ack1, is a DAT (zeige SLC6A3 Proteine) endocytic brake that stabilizes DAT (zeige SLC6A3 Proteine) at the plasma membrane.
ACK1 directly binds and phosphorylates the Arp2 (zeige AICDA Proteine)/3 regulatory protein (zeige TGFB1 Proteine) cortactin (zeige CTTN Proteine), potentially providing a direct link to Arp2 (zeige AICDA Proteine)/3-based actin dynamics during EGFR (zeige EGFR Proteine) degradation.
Ack1-mediated androgen receptor (zeige AR Proteine) phosphorylation modulates radiation resistance in castration-resistant prostate cancer
Ack1 mediated AKT/PKB (zeige AKT1 Proteine) tyrosine 176 phosphorylation regulates its activation
Ack1/Pyk1 tyrosine kinase (zeige TYRO3 Proteine) may be involved both in adult synaptic function and plasticity and in brain development.
Ack1 is up-regulated during development and is expressed in proliferative areas and in migratory pathways in the developing brain.
These experiments suggest a functional role for Ack as an early transducer of multiple extracellular stimuli.
These studies suggest that ACK1 senses signal of epidermal growth factor (EGF (zeige EGF Proteine)) and regulates ligand-induced degradation of EGFR (zeige EGFR Proteine).
This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.
activated CDC42 kinase 1
, activated Cdc42-associated kinase 1
, activated p21cdc42Hs kinase
, tyrosine kinase non-receptor protein 2
, Cdc42 GTPase-inhibiting protein
, P21cdc42Hs kinase
, non-receptor protein tyrosine kinase ACK
, activated CDC42 kinase 2