tyrosine Kinase, Non-Receptor, 2 Proteine (TNK2)

TNK2 encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. Zusätzlich bieten wir Ihnen tyrosine Kinase, Non-Receptor, 2 Antikörper (223) und tyrosine Kinase, Non-Receptor, 2 Kits (32) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TNK2 10188 Q07912
TNK2 303882 Q5U2X5
TNK2 51789 O54967
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,741.67
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,741.67
Details
Baculovirus infected Insect Cells Human GST tag 50 μg Anmelden zum Anzeigen 14 bis 16 Tage
$338.80
Details
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$338.33
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Insektenzellen Human His-GST 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$1,476.54
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Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$582.75
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Escherichia coli (E. coli) Human Unkonjugiert   5 applications Anmelden zum Anzeigen 1 bis 2 Tage
$318.85
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Baculovirus infected Insect Cells Human GST tag   5 μg Anmelden zum Anzeigen 10 bis 12 Tage
$346.62
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Insektenzellen Human GST tag   10 μg Anmelden zum Anzeigen 3 bis 4 Tage
$310.00
Details
Escherichia coli (E. coli) Human Unkonjugiert   5 applications Anmelden zum Anzeigen 1 bis 2 Tage
$345.00
Details

TNK2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, ,
Rat (Rattus)
Mouse (Murine) ,

Weitere Proteine zu tyrosine Kinase, Non-Receptor, 2 (TNK2) Interaktionspartnern

Human tyrosine Kinase, Non-Receptor, 2 (TNK2) Interaktionspartner

  1. blockade of ACK1/TNK2 could be a new therapeutic modality to target recalcitrant Prostate cancer stem-like cells.

  2. HSP90 is an upstream regulator of the ACK1-dependent phosphorylation of STAT1 and STAT3.

  3. we demonstrate that amplification of ACK1 promotes gastric tumorigenesis by inducing an ECD-dependent ubiquitination degradation of p53

  4. These findings suggest that ACK adopts a dock and coalesce binding mechanism with Cdc42. In contrast to other CRIB-family effectors and indeed other intrinsically disordered proteins, hydrophobic residues likely drive Cdc42-ACK binding.

  5. miR-24 represses metastasis of human osteosarcoma cells by targeting Ack1 via AKT-MMP2-MMP9 pathway.

  6. findings identify ACK1 as a novel SLP-76-associated protein-tyrosine kinase that modulates early activation events in T cells.

  7. ACK1 protein is increased extensively in colitis and colorectal dysplasia. ACK1 overexpression may play a role in colorectal inflammation and neoplasms.

  8. Ack1 overexpression promotes metastasis in hepatocellular carcinoma.

  9. Results found that the expression of ACK1 was significantly up-regulated in non-small-cell lung cancer (NSCLC) samples and demonstrate that ACK1 played an oncogenic role in the progression of NSCLC.

  10. Authors identified tyrosine kinase nonreceptor 2 (TNK2) point mutations that exhibited oncogenic capacity.

  11. that the cdc42-activated, nonreceptor tyrosine kinase, Ack1, is a DAT endocytic brake that stabilizes DAT at the plasma membrane.

  12. TNK2 (and TNR) harbored rare, genetic variants in individuals with familial Parkinson's Disease.

  13. Our results indicate that ACK1 is an independent prognostic marker and promotes hepatocellular carcinoma progression

  14. Studies indicate that activated CDC42 kinase 1 (ACK1) interacts with the estrogen receptor (ER) and regulates the activity of androgen receptor (AR) to promote the growth of breast cancer and prostate cancer.

  15. expression of Ack1 plays an important role as predictor of recurrence and poor outcome in hepatocellular carcinoma patients.

  16. ACK1 promotes EMT, migration, and invasion by activating AKT-POU2F1-ECD signalling in Gastric cancer cells. ACK1 may be employed as a new prognostic factor and therapeutic target for gastric cancer.

  17. We uncovered ten new mutations in TNK2 and DDR1 within serous and endometrioid ECs, thus providing novel insights into the mutation spectrum of each gene in EC.

  18. Increased ACK1 tyrosine phosphorylation correlated with upregulated PDGFR-beta activity and AKT activation.

  19. ACK1 interacts with KDM3A to regulate the mammary tumor oncogene HOXA1.

  20. A novel role for Ack1 in diverting activated EGFR into a non-canonical degradative pathway.

Mouse (Murine) tyrosine Kinase, Non-Receptor, 2 (TNK2) Interaktionspartner

  1. miR-24 represses metastasis of osteosarcoma cells by targeting Ack1 via AKT-MMP2-MMP9 pathway.

  2. findings identify ACK1 as a novel SLP-76-associated protein-tyrosine kinase that modulates early activation events in T cells.

  3. that the cdc42-activated, nonreceptor tyrosine kinase, Ack1, is a DAT endocytic brake that stabilizes DAT at the plasma membrane.

  4. ACK1 directly binds and phosphorylates the Arp2/3 regulatory protein cortactin, potentially providing a direct link to Arp2/3-based actin dynamics during EGFR degradation.

  5. Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer

  6. Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation

  7. Ack1/Pyk1 tyrosine kinase may be involved both in adult synaptic function and plasticity and in brain development.

  8. Ack1 is up-regulated during development and is expressed in proliferative areas and in migratory pathways in the developing brain.

  9. These experiments suggest a functional role for Ack as an early transducer of multiple extracellular stimuli.

  10. These studies suggest that ACK1 senses signal of epidermal growth factor (EGF) and regulates ligand-induced degradation of EGFR.

tyrosine Kinase, Non-Receptor, 2 (TNK2) Protein Überblick

Protein Überblick

This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.

Genbezeichner und Symbole assoziert mit TNK2

  • tyrosine kinase non receptor 2 (TNK2)
  • tyrosine kinase, non-receptor, 2 (Tnk2)
  • tyrosine kinase non receptor 2 (Tnk2)
  • tyrosine kinase, non-receptor, 1 (tnk1)
  • Ack Protein
  • ACK-1 Protein
  • ack1 Protein
  • ackb Protein
  • AW552477 Protein
  • Cdgip Protein
  • p21cdc42Hs Protein
  • Pyk1 Protein
  • tnk2 Protein
  • tnk2b Protein
  • wu:fj16g04 Protein
  • zgc:154019 Protein

Bezeichner auf Proteinebene für TNK2

activated CDC42 kinase 1 , activated Cdc42-associated kinase 1 , activated p21cdc42Hs kinase , tyrosine kinase non-receptor protein 2 , ACK-1 , Cdc42 GTPase-inhibiting protein , P21cdc42Hs kinase , non-receptor protein tyrosine kinase ACK , activated CDC42 kinase 2 , tyrosine kinase, non-receptor, 2 , tyrosine kinase, non-receptor, 2b

GENE ID SPEZIES
10188 Homo sapiens
303882 Rattus norvegicus
431014 Gallus gallus
51789 Mus musculus
280710 Bos taurus
100715920 Cavia porcellus
100513310 Sus scrofa
100350340 Oryctolagus cuniculus
565029 Danio rerio
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