tyrosine Kinase, Non-Receptor, 2 Proteine (TNK2)

TNK2 encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. Zusätzlich bieten wir Ihnen tyrosine Kinase, Non-Receptor, 2 Antikörper (222) und tyrosine Kinase, Non-Receptor, 2 Kits (32) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TNK2 10188 Q07912
TNK2 51789 O54967
TNK2 303882 Q5U2X5
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Showing 10 out of 12 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
Details
Baculovirus infected Insect Cells Human GST tag 50 μg Anmelden zum Anzeigen 20 bis 21 Tage
$272.80
Details
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$338.33
Details
Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$582.75
Details
Insektenzellen Human His-GST 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$1,502.67
Details
Escherichia coli (E. coli) Human Unkonjugiert   5 applications Anmelden zum Anzeigen 1 bis 2 Tage
$318.85
Details
Baculovirus infected Insect Cells Human GST tag   5 μg Anmelden zum Anzeigen 10 bis 12 Tage
$352.75
Details
Insektenzellen Human GST tag   10 μg Anmelden zum Anzeigen 3 bis 4 Tage
$310.00
Details
Escherichia coli (E. coli) Human Unkonjugiert   5 applications Anmelden zum Anzeigen 1 bis 2 Tage
$345.00
Details

TNK2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, ,
Mouse (Murine) ,

Rat (Rattus)

Weitere Proteine zu tyrosine Kinase, Non-Receptor, 2 (TNK2) Interaktionspartnern

Human tyrosine Kinase, Non-Receptor, 2 (TNK2) Interaktionspartner

  1. HSP90 (zeige HSP90 Proteine) is an upstream regulator of the ACK1-dependent phosphorylation of STAT1 (zeige STAT1 Proteine) and STAT3 (zeige STAT3 Proteine).

  2. we demonstrate that amplification of ACK1 promotes gastric tumorigenesis by inducing an ECD (zeige SHFM1 Proteine)-dependent ubiquitination degradation of p53 (zeige TP53 Proteine)

  3. These findings suggest that ACK adopts a dock and coalesce binding mechanism with Cdc42. In contrast to other CRIB-family effectors and indeed other intrinsically disordered proteins, hydrophobic residues likely drive Cdc42-ACK binding.

  4. miR (zeige MLXIP Proteine)-24 represses metastasis of human osteosarcoma cells by targeting Ack1 v (zeige AKT1 Proteine)ia AK (zeige MMP2 Proteine)T-MMP (zeige MMP9 Proteine)2-MMP9 pathway.

  5. findings identify ACK1 as a novel SLP-76 (zeige LCP2 Proteine)-associated protein-tyrosine kinase (zeige EPHA8 Proteine) that modulates early activation events in T cells.

  6. ACK1 protein is increased extensively in colitis and colorectal dysplasia. ACK1 overexpression may play a role in colorectal inflammation and neoplasms.

  7. Ack1 overexpression promotes metastasis in hepatocellular carcinoma.

  8. Results found that the expression of ACK1 was significantly up-regulated in non-small-cell lung cancer (NSCLC) samples and demonstrate that ACK1 played an oncogenic role in the progression of NSCLC.

  9. Authors identified tyrosine kinase (zeige TXK Proteine) nonreceptor 2 (TNK2) point mutations that exhibited oncogenic capacity.

  10. that the cdc42 (zeige CDC42 Proteine)-activated, nonreceptor tyrosine kinase (zeige TXK Proteine), Ack1, is a DAT (zeige SLC6A3 Proteine) endocytic brake that stabilizes DAT (zeige SLC6A3 Proteine) at the plasma membrane.

Mouse (Murine) tyrosine Kinase, Non-Receptor, 2 (TNK2) Interaktionspartner

  1. miR (zeige MLXIP Proteine)-24 represses metastasis of osteosarcoma cells by targeting Ack1 via AKT (zeige AKT1 Proteine)-MMP2 (zeige MMP2 Proteine)-MMP9 (zeige MMP9 Proteine) pathway.

  2. findings identify ACK1 as a novel SLP-76 (zeige LCP2 Proteine)-associated protein-tyrosine kinase (zeige YES1 Proteine) that modulates early activation events in T cells.

  3. that the cdc42 (zeige CDC42 Proteine)-activated, nonreceptor tyrosine kinase (zeige TYRO3 Proteine), Ack1, is a DAT (zeige SLC6A3 Proteine) endocytic brake that stabilizes DAT (zeige SLC6A3 Proteine) at the plasma membrane.

  4. ACK1 directly binds and phosphorylates the Arp2 (zeige AICDA Proteine)/3 regulatory protein (zeige TGFB1 Proteine) cortactin (zeige CTTN Proteine), potentially providing a direct link to Arp2 (zeige AICDA Proteine)/3-based actin dynamics during EGFR (zeige EGFR Proteine) degradation.

  5. Ack1-mediated androgen receptor (zeige AR Proteine) phosphorylation modulates radiation resistance in castration-resistant prostate cancer

  6. Ack1 mediated AKT/PKB (zeige AKT1 Proteine) tyrosine 176 phosphorylation regulates its activation

  7. Ack1/Pyk1 tyrosine kinase (zeige TYRO3 Proteine) may be involved both in adult synaptic function and plasticity and in brain development.

  8. Ack1 is up-regulated during development and is expressed in proliferative areas and in migratory pathways in the developing brain.

  9. These experiments suggest a functional role for Ack as an early transducer of multiple extracellular stimuli.

  10. These studies suggest that ACK1 senses signal of epidermal growth factor (EGF (zeige EGF Proteine)) and regulates ligand-induced degradation of EGFR (zeige EGFR Proteine).

tyrosine Kinase, Non-Receptor, 2 (TNK2) Protein Überblick

Protein Überblick

This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.

Genbezeichner und Symbole assoziert mit TNK2

  • tyrosine kinase non receptor 2 (TNK2)
  • tyrosine kinase, non-receptor, 2 (Tnk2)
  • tyrosine kinase non receptor 2 (Tnk2)
  • Ack Protein
  • ACK-1 Protein
  • ACK1 Protein
  • AW552477 Protein
  • Cdgip Protein
  • p21cdc42Hs Protein
  • Pyk1 Protein

Bezeichner auf Proteinebene für TNK2

activated CDC42 kinase 1 , activated Cdc42-associated kinase 1 , activated p21cdc42Hs kinase , tyrosine kinase non-receptor protein 2 , ACK-1 , Cdc42 GTPase-inhibiting protein , P21cdc42Hs kinase , non-receptor protein tyrosine kinase ACK , activated CDC42 kinase 2

GENE ID SPEZIES
10188 Homo sapiens
51789 Mus musculus
303882 Rattus norvegicus
100513310 Sus scrofa
280710 Bos taurus
431014 Gallus gallus
100350340 Oryctolagus cuniculus
100715920 Cavia porcellus
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