tyrosine Kinase, Non-Receptor, 2 Proteine (TNK2)

Human tyrosine Kinase, Non-Receptor, 2 (TNK2) Interaktionspartner

1. HSP90 (zeige HSP90 Proteine) is an upstream regulator of the ACK1-dependent phosphorylation of STAT1 (zeige STAT1 Proteine) and STAT3 (zeige STAT3 Proteine).

2. we demonstrate that amplification of ACK1 promotes gastric tumorigenesis by inducing an ECD (zeige SHFM1 Proteine)-dependent ubiquitination degradation of p53 (zeige TP53 Proteine)

3. These findings suggest that ACK adopts a dock and coalesce binding mechanism with Cdc42. In contrast to other CRIB-family effectors and indeed other intrinsically disordered proteins, hydrophobic residues likely drive Cdc42-ACK binding.

4. miR (zeige MLXIP Proteine)-24 represses metastasis of human osteosarcoma cells by targeting Ack1 v (zeige AKT1 Proteine)ia AK (zeige MMP2 Proteine)T-MMP (zeige MMP9 Proteine)2-MMP9 pathway.

5. findings identify ACK1 as a novel SLP-76 (zeige LCP2 Proteine)-associated protein-tyrosine kinase (zeige EPHA8 Proteine) that modulates early activation events in T cells.

6. ACK1 protein is increased extensively in colitis and colorectal dysplasia. ACK1 overexpression may play a role in colorectal inflammation and neoplasms.

7. Ack1 overexpression promotes metastasis in hepatocellular carcinoma.

8. Results found that the expression of ACK1 was significantly up-regulated in non-small-cell lung cancer (NSCLC) samples and demonstrate that ACK1 played an oncogenic role in the progression of NSCLC.

9. Authors identified tyrosine kinase (zeige TXK Proteine) nonreceptor 2 (TNK2) point mutations that exhibited oncogenic capacity.

10. that the cdc42 (zeige CDC42 Proteine)-activated, nonreceptor tyrosine kinase (zeige TXK Proteine), Ack1, is a DAT (zeige SLC6A3 Proteine) endocytic brake that stabilizes DAT (zeige SLC6A3 Proteine) at the plasma membrane.

Mouse (Murine) tyrosine Kinase, Non-Receptor, 2 (TNK2) Interaktionspartner

1. miR (zeige MLXIP Proteine)-24 represses metastasis of osteosarcoma cells by targeting Ack1 via AKT (zeige AKT1 Proteine)-MMP2 (zeige MMP2 Proteine)-MMP9 (zeige MMP9 Proteine) pathway.

2. findings identify ACK1 as a novel SLP-76 (zeige LCP2 Proteine)-associated protein-tyrosine kinase (zeige YES1 Proteine) that modulates early activation events in T cells.

3. that the cdc42 (zeige CDC42 Proteine)-activated, nonreceptor tyrosine kinase (zeige TYRO3 Proteine), Ack1, is a DAT (zeige SLC6A3 Proteine) endocytic brake that stabilizes DAT (zeige SLC6A3 Proteine) at the plasma membrane.

4. ACK1 directly binds and phosphorylates the Arp2 (zeige AICDA Proteine)/3 regulatory protein (zeige TGFB1 Proteine) cortactin (zeige CTTN Proteine), potentially providing a direct link to Arp2 (zeige AICDA Proteine)/3-based actin dynamics during EGFR (zeige EGFR Proteine) degradation.

5. Ack1-mediated androgen receptor (zeige AR Proteine) phosphorylation modulates radiation resistance in castration-resistant prostate cancer

6. Ack1 mediated AKT/PKB (zeige AKT1 Proteine) tyrosine 176 phosphorylation regulates its activation

7. Ack1/Pyk1 tyrosine kinase (zeige TYRO3 Proteine) may be involved both in adult synaptic function and plasticity and in brain development.

8. Ack1 is up-regulated during development and is expressed in proliferative areas and in migratory pathways in the developing brain.

9. These experiments suggest a functional role for Ack as an early transducer of multiple extracellular stimuli.

10. These studies suggest that ACK1 senses signal of epidermal growth factor (EGF (zeige EGF Proteine)) and regulates ligand-induced degradation of EGFR (zeige EGFR Proteine).