tyrosine Kinase, Non-Receptor, 2 Proteine (TNK2)

TNK2 encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. Zusätzlich bieten wir Ihnen und tyrosine Kinase, Non-Receptor, 2 Kits (32) und viele weitere Produktgruppen zu diesem Protein an.

Gen	GeneID	UniProt
TNK2	10188	Q07912
TNK2	303882	Q5U2X5
TNK2	51789	O54967

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Katalog Nr.	Origin	Quelle	Konjugat	Menge	Anbieter	Lieferzeit	Preis	Details
ABIN3088053	Insektenzellen	Human	His tag	1 mg	Anmelden zum Anzeigen	70 Days	$13,984.89	Details
ABIN3131827	Insektenzellen	Maus	His tag	1 mg	Anmelden zum Anzeigen	70 Days	$13,984.89	Details
ABIN2216124	Baculovirus infected Insect Cells	Human	GST tag	50 μg	Anmelden zum Anzeigen	20 bis 21 Tage	$272.80	Details
ABIN1323266	Wheat germ	Human	GST tag	2 μg	Anmelden zum Anzeigen	11 bis 12 Tage	$338.33	Details
ABIN5569770	Insektenzellen	Human	His-GST	100 μg	Anmelden zum Anzeigen	11 bis 12 Tage	$1,502.67	Details
ABIN6126763	Escherichia coli (E. coli)	Human	Unkonjugiert	100 μg	Anmelden zum Anzeigen	11 bis 18 Tage	$582.75	Details
ABIN2747298	Escherichia coli (E. coli)	Human	Unkonjugiert	5 applications	Anmelden zum Anzeigen	1 bis 2 Tage	$318.85	Details
ABIN2960058	Baculovirus infected Insect Cells	Human	GST tag	5 μg	Anmelden zum Anzeigen	10 bis 12 Tage	$352.75	Details
ABIN5508792	Insektenzellen	Human	GST tag	10 μg	Anmelden zum Anzeigen	3 bis 4 Tage	$310.00	Details
ABIN2749243	Escherichia coli (E. coli)	Human	Unkonjugiert	5 applications	Anmelden zum Anzeigen	1 bis 2 Tage	$345.00	Details

TNK2 Proteine nach Spezies und Herkunft

Origin	Exprimiert in	Konjugat
Human	, , ,	, ,
Rat (Rattus)
Mouse (Murine)	,

Weitere Produktkategorien zu tyrosine Kinase, Non-Receptor, 2 Protein

Weitere Proteine zu tyrosine Kinase, Non-Receptor, 2 (TNK2) Interaktionspartnern

Human tyrosine Kinase, Non-Receptor, 2 (TNK2) Interaktionspartner

HSP90 (zeige HSP90 Proteine) is an upstream regulator of the ACK1-dependent phosphorylation of STAT1 (zeige STAT1 Proteine) and STAT3 (zeige STAT3 Proteine).
we demonstrate that amplification of ACK1 promotes gastric tumorigenesis by inducing an ECD (zeige SHFM1 Proteine)-dependent ubiquitination degradation of p53 (zeige TP53 Proteine)
These findings suggest that ACK adopts a dock and coalesce binding mechanism with Cdc42. In contrast to other CRIB-family effectors and indeed other intrinsically disordered proteins, hydrophobic residues likely drive Cdc42-ACK binding.
miR (zeige MLXIP Proteine)-24 represses metastasis of human osteosarcoma cells by targeting Ack1 v (zeige AKT1 Proteine)ia AK (zeige MMP2 Proteine)T-MMP (zeige MMP9 Proteine)2-MMP9 pathway.
findings identify ACK1 as a novel SLP-76 (zeige LCP2 Proteine)-associated protein-tyrosine kinase (zeige EPHA8 Proteine) that modulates early activation events in T cells.
ACK1 protein is increased extensively in colitis and colorectal dysplasia. ACK1 overexpression may play a role in colorectal inflammation and neoplasms.
Ack1 overexpression promotes metastasis in hepatocellular carcinoma.
Results found that the expression of ACK1 was significantly up-regulated in non-small-cell lung cancer (NSCLC) samples and demonstrate that ACK1 played an oncogenic role in the progression of NSCLC.
Authors identified tyrosine kinase (zeige TXK Proteine) nonreceptor 2 (TNK2) point mutations that exhibited oncogenic capacity.
that the cdc42 (zeige CDC42 Proteine)-activated, nonreceptor tyrosine kinase (zeige TXK Proteine), Ack1, is a DAT (zeige SLC6A3 Proteine) endocytic brake that stabilizes DAT (zeige SLC6A3 Proteine) at the plasma membrane.

Mouse (Murine) tyrosine Kinase, Non-Receptor, 2 (TNK2) Interaktionspartner

miR (zeige MLXIP Proteine)-24 represses metastasis of osteosarcoma cells by targeting Ack1 via AKT (zeige AKT1 Proteine)-MMP2 (zeige MMP2 Proteine)-MMP9 (zeige MMP9 Proteine) pathway.
findings identify ACK1 as a novel SLP-76 (zeige LCP2 Proteine)-associated protein-tyrosine kinase (zeige YES1 Proteine) that modulates early activation events in T cells.
that the cdc42 (zeige CDC42 Proteine)-activated, nonreceptor tyrosine kinase (zeige TYRO3 Proteine), Ack1, is a DAT (zeige SLC6A3 Proteine) endocytic brake that stabilizes DAT (zeige SLC6A3 Proteine) at the plasma membrane.
ACK1 directly binds and phosphorylates the Arp2 (zeige AICDA Proteine)/3 regulatory protein (zeige TGFB1 Proteine) cortactin (zeige CTTN Proteine), potentially providing a direct link to Arp2 (zeige AICDA Proteine)/3-based actin dynamics during EGFR (zeige EGFR Proteine) degradation.
Ack1-mediated androgen receptor (zeige AR Proteine) phosphorylation modulates radiation resistance in castration-resistant prostate cancer
Ack1 mediated AKT/PKB (zeige AKT1 Proteine) tyrosine 176 phosphorylation regulates its activation
Ack1/Pyk1 tyrosine kinase (zeige TYRO3 Proteine) may be involved both in adult synaptic function and plasticity and in brain development.
Ack1 is up-regulated during development and is expressed in proliferative areas and in migratory pathways in the developing brain.
These experiments suggest a functional role for Ack as an early transducer of multiple extracellular stimuli.
These studies suggest that ACK1 senses signal of epidermal growth factor (EGF (zeige EGF Proteine)) and regulates ligand-induced degradation of EGFR (zeige EGFR Proteine).

tyrosine Kinase, Non-Receptor, 2 (TNK2) Protein Überblick

Protein Überblick

This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.

Genbezeichner und Symbole assoziert mit TNK2

tyrosine kinase non receptor 2 (TNK2)
tyrosine kinase, non-receptor, 2 (Tnk2)
tyrosine kinase non receptor 2 (Tnk2)
tyrosine kinase, non-receptor, 1 (tnk1)

Ack Protein
ACK-1 Protein
ack1 Protein
ackb Protein
AW552477 Protein
Cdgip Protein
p21cdc42Hs Protein
Pyk1 Protein
tnk2 Protein
tnk2b Protein
wu:fj16g04 Protein
zgc:154019 Protein

Bezeichner auf Proteinebene für TNK2

activated CDC42 kinase 1 , activated Cdc42-associated kinase 1 , activated p21cdc42Hs kinase , tyrosine kinase non-receptor protein 2 , ACK-1 , Cdc42 GTPase-inhibiting protein , P21cdc42Hs kinase , non-receptor protein tyrosine kinase ACK , activated CDC42 kinase 2 , tyrosine kinase, non-receptor, 2 , tyrosine kinase, non-receptor, 2b

GENE ID	SPEZIES
10188	Homo sapiens
303882	Rattus norvegicus
431014	Gallus gallus
51789	Mus musculus
280710	Bos taurus
100715920	Cavia porcellus
100513310	Sus scrofa
100350340	Oryctolagus cuniculus
565029	Danio rerio

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