tyrosine Kinase, Non-Receptor, 2 Proteine (TNK2)

Human tyrosine Kinase, Non-Receptor, 2 (TNK2) Interaktionspartner

1. blockade of ACK1/TNK2 could be a new therapeutic modality to target recalcitrant Prostate cancer stem-like cells.

2. HSP90 is an upstream regulator of the ACK1-dependent phosphorylation of STAT1 and STAT3.

3. we demonstrate that amplification of ACK1 promotes gastric tumorigenesis by inducing an ECD-dependent ubiquitination degradation of p53

4. These findings suggest that ACK adopts a dock and coalesce binding mechanism with Cdc42. In contrast to other CRIB-family effectors and indeed other intrinsically disordered proteins, hydrophobic residues likely drive Cdc42-ACK binding.

5. miR-24 represses metastasis of human osteosarcoma cells by targeting Ack1 via AKT-MMP2-MMP9 pathway.

6. findings identify ACK1 as a novel SLP-76-associated protein-tyrosine kinase that modulates early activation events in T cells.

7. ACK1 protein is increased extensively in colitis and colorectal dysplasia. ACK1 overexpression may play a role in colorectal inflammation and neoplasms.

8. Ack1 overexpression promotes metastasis in hepatocellular carcinoma.

9. Results found that the expression of ACK1 was significantly up-regulated in non-small-cell lung cancer (NSCLC) samples and demonstrate that ACK1 played an oncogenic role in the progression of NSCLC.

10. Authors identified tyrosine kinase nonreceptor 2 (TNK2) point mutations that exhibited oncogenic capacity.

11. that the cdc42-activated, nonreceptor tyrosine kinase, Ack1, is a DAT endocytic brake that stabilizes DAT at the plasma membrane.

12. TNK2 (and TNR) harbored rare, genetic variants in individuals with familial Parkinson's Disease.

13. Our results indicate that ACK1 is an independent prognostic marker and promotes hepatocellular carcinoma progression

14. Studies indicate that activated CDC42 kinase 1 (ACK1) interacts with the estrogen receptor (ER) and regulates the activity of androgen receptor (AR) to promote the growth of breast cancer and prostate cancer.

15. expression of Ack1 plays an important role as predictor of recurrence and poor outcome in hepatocellular carcinoma patients.

16. ACK1 promotes EMT, migration, and invasion by activating AKT-POU2F1-ECD signalling in Gastric cancer cells. ACK1 may be employed as a new prognostic factor and therapeutic target for gastric cancer.

17. We uncovered ten new mutations in TNK2 and DDR1 within serous and endometrioid ECs, thus providing novel insights into the mutation spectrum of each gene in EC.

18. Increased ACK1 tyrosine phosphorylation correlated with upregulated PDGFR-beta activity and AKT activation.

19. ACK1 interacts with KDM3A to regulate the mammary tumor oncogene HOXA1.

20. A novel role for Ack1 in diverting activated EGFR into a non-canonical degradative pathway.

Mouse (Murine) tyrosine Kinase, Non-Receptor, 2 (TNK2) Interaktionspartner

1. miR-24 represses metastasis of osteosarcoma cells by targeting Ack1 via AKT-MMP2-MMP9 pathway.

2. findings identify ACK1 as a novel SLP-76-associated protein-tyrosine kinase that modulates early activation events in T cells.

3. that the cdc42-activated, nonreceptor tyrosine kinase, Ack1, is a DAT endocytic brake that stabilizes DAT at the plasma membrane.

4. ACK1 directly binds and phosphorylates the Arp2/3 regulatory protein cortactin, potentially providing a direct link to Arp2/3-based actin dynamics during EGFR degradation.

5. Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer

6. Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation

7. Ack1/Pyk1 tyrosine kinase may be involved both in adult synaptic function and plasticity and in brain development.

8. Ack1 is up-regulated during development and is expressed in proliferative areas and in migratory pathways in the developing brain.

9. These experiments suggest a functional role for Ack as an early transducer of multiple extracellular stimuli.

10. These studies suggest that ACK1 senses signal of epidermal growth factor (EGF) and regulates ligand-induced degradation of EGFR.