tRNA Nucleotidyl Transferase, CCA-Adding, 1 Proteine (Trnt1)

The CCA-adding enzyme TRNT1 (EC 2.7.7.25) is an essential enzyme that catalyzes the addition of the CCA terminus to the 3-prime end of tRNA precursors. Zusätzlich bieten wir Ihnen Trnt1 Antikörper (10) und Trnt1 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Trnt1 51095 Q96Q11
Ratte Trnt1 Trnt1 312616  
Trnt1 70047 Q8K1J6
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,370.21
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Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,370.21
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
$888.80
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Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$338.33
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Trnt1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Weitere Proteine zu tRNA Nucleotidyl Transferase, CCA-Adding, 1 (Trnt1) Interaktionspartnern

Human tRNA Nucleotidyl Transferase, CCA-Adding, 1 (Trnt1) Interaktionspartner

  1. Peripheral B-cell deficiency of TRNT1 deficiency may be associated with augmented ER stress in immature B cells in the bone marrow.

  2. We studied nine patients with biallelic mutations in TRNT1 and the syndrome of congenital sideroblastic anaemia with immunodeficiency, fevers and developmental delay. Mutations of TRNT1 lead to a severe and often fatal syndrome, linking protein homeostasis and autoinflammation.

  3. In vitro studies of disease-linked variants of human tRNA nucleotidyltransferase reveal decreased thermal stability and altered catalytic activity.

  4. patient-specific induced pluripotent stem cells (iPSCs) and iPSC-derived retinal organoids from dermal fibroblasts of patients with molecularly confirmed TRNT1-associated retinitis pigmentosa.

  5. Data show that the disease causing mutations in patient-derived fibroblasts do not affect subcellular localization of TRNT1 and show no gross morphological differences when compared to control cells.

  6. family expands the ocular and systemic phenotypes associated with mutations in TRNT1, demonstrating phenotypic variability and highlighting the need for ophthalmic review of these patients.

  7. two non-syndromic retinitis pigmentosa pedigrees with segregating mutations in TRNT1

  8. The clinical phenotypes associated with TRNT1 mutations are largely due to impaired mitochondrial translation, resulting from defective CCA addition to mitochondrial tRNA(Ser(AGY)).

  9. A model of action is proposed, where motif C forms a flexible spring element modulating the relative orientation of the enzyme's head and body domains to accommodate the growing 3'-end of the tRNA.

  10. The discriminator base represents an important substrate recognition element for tRNA nucleotidyltransferases.

  11. Tandem CCA addition is not the result of a modified enzymatic activity that is particular to unstable RNAs. Rather, it is a consequence of the natural activity of the CCA-adding enzyme on a substrate with increased conformational flexibility, the CCA-adding enzyme is able to trigger the degradation of potentially detrimental small RNAs and tRNAs.

  12. The patient-associated TRNT1 mutations result in partial loss of function of TRNT1 and lead to metabolic defects in both the mitochondria and cytosol, which can account for the phenotypic pleiotropy.

  13. human gene transcript CGI-47 (#AF151805) was cloned and encodes a bona fide CCA-adding enzyme and not a poly(A) polymerase.

  14. The crystal structure reveals a four domain architecture with a cluster of conserved residues forming a positively charged cleft between the first two domains.

  15. These findings strongly suggest that the splice variant of the human CCA-adding enzyme is expressed in the cell although the in vivo function remains unclear.

  16. is a RNA polymerase which newly adds CCA sequence to tRNA 3'terminal. This reaction was named as Vice-Anchored Knock-in and Lock Dynamics.[review]

Trnt1 Protein Überblick

Protein Überblick

The CCA-adding enzyme TRNT1 (EC 2.7.7.25) is an essential enzyme that catalyzes the addition of the CCA terminus to the 3-prime end of tRNA precursors. This reaction is a fundamental prerequisite for mature tRNAs to become aminoacylated and to participate in protein biosynthesis (Lizano et al., 2007

Genbezeichner und Symbole assoziert mit Trnt1

  • tRNA nucleotidyl transferase 1 (TRNT1)
  • tRNA nucleotidyl transferase, CCA-adding, 1 (trnt1)
  • tRNA nucleotidyl transferase, CCA-adding, 1 L homeolog (trnt1.L)
  • tRNA nucleotidyl transferase 1 (Trnt1)
  • tRNA nucleotidyl transferase, CCA-adding, 1 (Trnt1)
  • 2410043H24Rik Protein
  • 2610044E04Rik Protein
  • 9830143O18Rik Protein
  • AA408384 Protein
  • bMtCCA Protein
  • C76540 Protein
  • CCA1 Protein
  • CGI-47 Protein
  • mt-Trat Protein
  • MtCCA Protein
  • TRNT1 Protein
  • zgc:86645 Protein

Bezeichner auf Proteinebene für Trnt1

CCA tRNA nucleotidyltransferase 1, mitochondrial , tRNA-nucleotidyltransferase , tRNA-nucleotidyltransferase 1, mitochondrial , tRNA nucleotidyl transferase, CCA-adding, 1 , tRNA-nucleotidyltransferase 1, mitochondrial-like , mitochondrial CCA-adding tRNA-nucleotidyltransferase , mitochondrial tRNA nucleotidyl transferase, CCA-adding , mt CCA-adding enzyme , mt tRNA CCA-diphosphorylase , mt tRNA CCA-pyrophosphorylase , mt tRNA adenylyltransferase , tRNA adenylyltransferase, mitochondrial

GENE ID SPEZIES
407144 Bos taurus
415249 Danio rerio
734914 Xenopus laevis
476552 Canis lupus familiaris
394602 Xenopus (Silurana) tropicalis
470735 Pan troglodytes
704550 Macaca mulatta
100053009 Equus caballus
100074783 Ornithorhynchus anatinus
100153838 Sus scrofa
100414825 Callithrix jacchus
100449831 Pongo abelii
100479227 Ailuropoda melanoleuca
100585151 Nomascus leucogenys
51095 Homo sapiens
312616 Rattus norvegicus
70047 Mus musculus
Ausgewählte Anbieter für Trnt1 Proteine (Trnt1)
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