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The protein encoded by SRSF2 is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Zusätzlich bieten wir Ihnen SRSF2 Antikörper (34) und SRSF2 Kits (17) und viele weitere Produktgruppen zu diesem Protein an.
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We found that SON and SC35 (also known as SRSF2) localize to the central region of the speckle, whereas MALAT1 and small nuclear (sn)RNAs are enriched at the speckle periphery.
Through a serial mutagenesis, authors demonstrate that a 10 nt RNA sequence surrounding the branch-point (BP), is important for SRSF2-mediated inhibition of cassette exon inclusion through directly interacting with SRSF2.
The aberrantly spliced target genes and deregulated cellular pathways associated with the commonly mutated splicing factor (zeige SLU7 Proteine) genes in myelodysplastic syndromes (SF3B1 (zeige SF3B2 Proteine), SRSF2 and U2AF1 (zeige U2AF1 Proteine)) are being identified, illuminating the molecular mechanisms underlying the disease. (Review)
adverse prognostic impact of SRSF2 mutations on OS and AML (zeige RUNX1 Proteine) transformation in patients with de novo MDS (zeige PAFAH1B1 Proteine)
SRSF2 mutation is associated with chronic myelomonocytic leukemia.
Mutation in SRSF2 gene is associated with Uveal Melanoma.
Myelodysplastic syndrome -related P95 (zeige NBN Proteine) point mutants of SRSF2 lead to alternative splicing of CDC25C (zeige CDC25C Proteine) in a manner that is not dependent on the DNA damage response.
Findings identify SRSF2 as a key regulator of RNA splicing dysregulation in cancer, with possible clinical implications as a candidate prognostic factor in patients with HCC (zeige FAM126A Proteine).
depletion of the splicing factor (zeige SLU7 Proteine) arginine-rich splicing factor 2 (zeige SRSF1 Proteine) (SRSF2) leads to enhanced cytotoxicity of breast cancer cells by KM100
Data suggest that RBM25 is required for the viability of multiple human cell lines, suggesting that it could play a key role in pre-mRNA splicing; a region of RBM25 spanning Lys77 binds with high affinity to SRSF2, a crucial protein in exon definition, but only when Lys77 is unmethylated. (RBM25 = RNA binding motif protein 25; SRSF2 = serine- and arginine-rich splicing factor 2 (zeige SRSF1 Proteine))
Mice expressing Srsf2 mutation Srsf2P95H, which commonly occurs in individuals with MDS (zeige MECOM Proteine) and AML (zeige RUNX1 Proteine), in an inducible, hemizygous manner in hematopoietic cells rapidly succumbed to fatal bone marrow failure, demonstrating that Srsf2-mutated cells depend on the wild-type Srsf2 allele for survival.
Findings have shown that SRSF2 not only is involved in splicing regulation of a large number of transcripts but also activates transcription of metabolism-related genes and transcription factors.
Depletion of SRSF2 enhances reovirus replication and cytopathic effect, suggesting that T1L (zeige CERS6 Proteine) mu2 (zeige AP2M1 Proteine) modulation of splicing benefits the virus.
HIV-1-Tat (zeige TAT Proteine) Protein Inhibits SC35-mediated Tau Exon 10 Inclusion through Up-regulation of DYRK1A (zeige DYRK1A Proteine) Kinase.
The findings suggest that intact SRSF2 is essential for the functional integrity of the hematopoietic system and that its mutations likely contribute to development of myelodysplastic syndromes.
SRSF2 mutations alter SRSF2's normal sequence-specific RNA binding activity, thereby altering the recognition of specific exonic splicing enhancer motifs to drive recurrent mis (zeige AMH Proteine)-splicing of key hematopoietic regulators
Study reports that SRSF2 (also known as SC35, an SR-splicing factor (zeige SLU7 Proteine)) is part of the 7SK complex assembled at gene promoters and plays a direct role in transcription pause release.
Specific effects on regulated splicing by SR proteins SRSF1 (zeige SRSF1 Proteine) and SRSF2 depends on a complex set of relationships with multiple other SR proteins in mammalian genomes.
Deficiency of the splicing factor (zeige SLU7 Proteine) Sfrs10 results in early embryonic lethality in mice and has no impact on full-length SMN/Smn (zeige STMN1 Proteine) splicing.
Oct-4 distribution was examined relative to that of the unphosphorylated form of RNA polymerase II (Pol II) and splicing factor (SC 35) in the intranuclear entities such as perichromatin fibrils.
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein and one non-coding transcript variant have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 11.
SR splicing factor 2
, splicing component, 35 kDa
, splicing factor SC35
, splicing factor, arginine/serine-rich 2
, myelin regulatory factor 1
, putative myelin regulatory factor 1
, splicing factor Sc35
, splicing factor, arginine/serine-rich 2 (SC-35)
, PR 264 protein
, arginine/serine-rich2 splicing factor