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The protein encoded by SPINT1 is a member of the Kunitz family of serine protease inhibitors. Zusätzlich bieten wir Ihnen serine Peptidase Inhibitor, Kunitz Type 1 Antikörper (85) und serine Peptidase Inhibitor, Kunitz Type 1 Kits (13) und viele weitere Produktgruppen zu diesem Protein an.
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Results suggest that insufficient hepatocyte growth factor activator inhibitor type 1 (HAI-1) function promotes intestinal carcinogenesis by activating nuclear factor-kappaB (NF-kappaB (zeige NFKB1 Proteine)) signaling.
By completing our structural characterization of the previously unknown N-terminal region of HAI-1, we provide new insight into the interplay between tertiary structure and the inhibitory activity of a multidomain protease inhibitor
HAI-1 may have a critical role in maintaining normal keratinocyte morphology through regulation of PAR-2 (zeige F2RL1 Proteine)-dependent p38 mitogen-activated protein kinase (zeige MAPK14 Proteine) signaling.
HAI-1 regulates the activity of activated matriptase (zeige ST14 Proteine), whereas HAI-2 (zeige SPINT2 Proteine) has an essential role in regulating prostasin (zeige PRSS8 Proteine)-dependent matriptase (zeige ST14 Proteine) zymogen activation.
HAI-1 and HAI-2 influence proliferation and cell fate of NPCs and their expression levels are linked to BMP sign
HAI-1/SPINT1 has a crucial role in suppressing intestinal tumorigenesis, which implies a novel link between epithelial cell surface (zeige EPCAM Proteine) serine protease (zeige F2 Proteine) inhibitors and protection from carcinogenic stimuli.
mutations in Prss8 (zeige PRSS8 Proteine) restored placentation and normal development of HAI-1-deficient embryos and prevented early embryonic lethality, mid-gestation lethality due to placental labyrinth failure, and neural tube defects in HAI-2 (zeige SPINT2 Proteine)-deficient embryos.
HAI-1 has a crucial suppressive role in oral squamous cell carcinoma cells' invasiveness.
HAI-1 and -2 are overexpressed in the liver in cholangiopathies with ductular reactions and are possibly involved in liver fibrosis and hepatic differentiation.
HAI-1/SPINT1 plays an important role in maintaining colonic epithelium integrity.
The SPINT1 expression was associated with extrathyroidal invasion, lymphovascular invasion, lymph node metastasis, advanced TNM (zeige ODZ1 Proteine) stage, and a higher risk of recurrence in differentiated thyroid cancer.
HAI-1 is upregulated in pancreatic intraepithelial neoplasia and broadly expressed in pancreatic ductal adenocarcinoma (PDAC) cells. However, PDAC cases having areas of reduced HAI-1 immunoreactivity may show shorter disease-free survival.
In this work, KLK14 (zeige KLK14 Proteine) binding to either hepatocyte growth factor activator inhibitor type-1 (HAI-1) or type-2 (HAI-2 (zeige SPINT2 Proteine)) was essayed using homology modeling, molecular dynamic simulations and free-energy calculations through MM/PBSA and MM/GBSA. KLK14 (zeige KLK14 Proteine) was successfully modeled.
the cell surface expression of HAI-1 in all viable epidermal layers renders it an effective regulator for matriptase (zeige ST14 Proteine) and prostasin (zeige PRSS8 Proteine)
Data suggest that HAI1, a protease on the surface of colon carcinoma cells, is an MMP7 (zeige MMP7 Proteine) substrate; proteolysis by MMP7 (zeige MMP7 Proteine) releases extracellular region as soluble HAI1 (sHAI1); sHAI1 induces cancer cell aggregation; cholesterol sulfate is required for MMP-7 (zeige MMP7 Proteine)--catalyzed generation of sHAI1. (HAI1 = hepatocyte growth factor activator inhibitor type 1; MMP7 (zeige MMP7 Proteine) = matrix metalloproteinase-7 (zeige MMP7 Proteine))
Concomitant presence of TMPRSS13 (zeige TMPRSS13 Proteine) with HAI-1 mediates phosphorylation of residues in the intracellular domain of the protease, and it coincides with efficient transport of the protease to the cell surface and its subsequent shedding.
our data illustrated a novel pathway comprising miR (zeige MLXIP Proteine)-221and miR (zeige MLXIP Proteine)-222 and hepatocyte growth factor activator inhibitor type 1 in gastric cancer, which is a potential target for future clinical use
DNA methylation (zeige HELLS Proteine) levels in the COASY (zeige COASY Proteine) and SPINT1 promoter regions were considered to potentially be a convenient and useful biomarker for diagnosis of Alzheimer's Disease and Amnestic Mild Cognitive Impairment.
The structural insights gained here improve our understanding of the regulation of HAI-1 inhibitory activities and point to new approaches for better controlling these activities.
The present study demonstrated that ovarian cancer cell metastasis and invasion were more dependent on upregulation of matriptase (zeige ST14 Proteine) levels than downregulation of HAI1. Matriptase (zeige ST14 Proteine) may be a potential adjuvant therapeutic target for inhibiting ovarian cancer invasion and metastasis.
Results describe the live imaging of chronic inflammation caused by mutation of zebrafish Hai1.
The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms.
serine peptidase inhibitor, Kunitz type 1
, kunitz-type protease inhibitor 1
, kunitz-type protease inhibitor 1-like
, hepatocyte growth factor activator inhibitor type 1
, hepatocyte growth factor activator inhibitor 1
, hepatocyte growth factor activator inhibitor-1
, serine protease inhibitor, Kunitz type 1
, serine peptidase inhibitor, Kunitz type 1 a
, serine protease inhibitor HGFAI
, serine protease inhibitor, Kunitz type 1 b