serine Peptidase Inhibitor, Kunitz Type 1 Proteine (SPINT1)

The protein encoded by SPINT1 is a member of the Kunitz family of serine protease inhibitors. Zusätzlich bieten wir Ihnen serine Peptidase Inhibitor, Kunitz Type 1 Antikörper (85) und serine Peptidase Inhibitor, Kunitz Type 1 Kits (13) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SPINT1 20732 Q9R097
Ratte SPINT1 SPINT1 311331  
SPINT1 6692 O43278
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Top serine Peptidase Inhibitor, Kunitz Type 1 Proteine auf antikoerper-online.de

Showing 6 out of 8 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
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Human Cells Maus Fc Tag 10 μg Anmelden zum Anzeigen 14 bis 16 Tage
$250.80
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Human Cells Human His tag 10 μg Anmelden zum Anzeigen 14 bis 16 Tage
$250.80
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$547.80
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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SPINT1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) ,
,
Human , , ,
, ,

Weitere Proteine zu serine Peptidase Inhibitor, Kunitz Type 1 (SPINT1) Interaktionspartnern

Mouse (Murine) serine Peptidase Inhibitor, Kunitz Type 1 (SPINT1) Interaktionspartner

  1. Results suggest that insufficient hepatocyte growth factor activator inhibitor type 1 (HAI-1) function promotes intestinal carcinogenesis by activating nuclear factor-kappaB (NF-kappaB) signaling.

  2. By completing our structural characterization of the previously unknown N-terminal region of HAI-1, we provide new insight into the interplay between tertiary structure and the inhibitory activity of a multidomain protease inhibitor

  3. HAI-1 may have a critical role in maintaining normal keratinocyte morphology through regulation of PAR-2-dependent p38 mitogen-activated protein kinase signaling.

  4. HAI-1 regulates the activity of activated matriptase, whereas HAI-2 has an essential role in regulating prostasin-dependent matriptase zymogen activation.

  5. HAI-1 and HAI-2 influence proliferation and cell fate of NPCs and their expression levels are linked to BMP sign

  6. HAI-1/SPINT1 has a crucial role in suppressing intestinal tumorigenesis, which implies a novel link between epithelial cell surface serine protease inhibitors and protection from carcinogenic stimuli.

  7. mutations in Prss8 restored placentation and normal development of HAI-1-deficient embryos and prevented early embryonic lethality, mid-gestation lethality due to placental labyrinth failure, and neural tube defects in HAI-2-deficient embryos.

  8. HAI-1 has a crucial suppressive role in oral squamous cell carcinoma cells' invasiveness.

  9. HAI-1 and -2 are overexpressed in the liver in cholangiopathies with ductular reactions and are possibly involved in liver fibrosis and hepatic differentiation.

  10. HAI-1/SPINT1 plays an important role in maintaining colonic epithelium integrity.

  11. HAI-1 is required for branching morphogenesis in the chorioallantoic placenta.

  12. Hepatocyte growth factor activator inhibitor-1 (HAI-1) is essential for the integrity of basement membranes in the developing placental labyrinth.

  13. HAI-1, in addition to its protease inhibitory function, plays a role in transporting matriptase as a matriptase-HAI-1 complex from the basolateral plama membrane to the apical plasma membrane

  14. Unlike HAI-1 and matriptase, HAI-2 expression is detected in non-epithelial cells of brain and lymph nodes, suggesting that HAI-2 may also be involved in inhibition of serine proteases other than matriptase

  15. These findings indicate that Hai-1/Spint1 has critical roles in the regulated keratinization of the epidermis and hair development.

  16. This study identifies matriptase suppression as an essential function of HAI-1 in postnatal tissue homeostasis.

Human serine Peptidase Inhibitor, Kunitz Type 1 (SPINT1) Interaktionspartner

  1. The SPINT1 expression was associated with extrathyroidal invasion, lymphovascular invasion, lymph node metastasis, advanced TNM stage, and a higher risk of recurrence in differentiated thyroid cancer.

  2. HAI-1 is upregulated in pancreatic intraepithelial neoplasia and broadly expressed in pancreatic ductal adenocarcinoma (PDAC) cells. However, PDAC cases having areas of reduced HAI-1 immunoreactivity may show shorter disease-free survival.

  3. In this work, KLK14 binding to either hepatocyte growth factor activator inhibitor type-1 (HAI-1) or type-2 (HAI-2) was essayed using homology modeling, molecular dynamic simulations and free-energy calculations through MM/PBSA and MM/GBSA. KLK14 was successfully modeled.

  4. the cell surface expression of HAI-1 in all viable epidermal layers renders it an effective regulator for matriptase and prostasin

  5. Data suggest that HAI1, a protease on the surface of colon carcinoma cells, is an MMP7 substrate; proteolysis by MMP7 releases extracellular region as soluble HAI1 (sHAI1); sHAI1 induces cancer cell aggregation; cholesterol sulfate is required for MMP-7--catalyzed generation of sHAI1. (HAI1 = hepatocyte growth factor activator inhibitor type 1; MMP7 = matrix metalloproteinase-7)

  6. Concomitant presence of TMPRSS13 with HAI-1 mediates phosphorylation of residues in the intracellular domain of the protease, and it coincides with efficient transport of the protease to the cell surface and its subsequent shedding.

  7. our data illustrated a novel pathway comprising miR-221and miR-222 and hepatocyte growth factor activator inhibitor type 1 in gastric cancer, which is a potential target for future clinical use

  8. DNA methylation levels in the COASY and SPINT1 promoter regions were considered to potentially be a convenient and useful biomarker for diagnosis of Alzheimer's Disease and Amnestic Mild Cognitive Impairment.

  9. The structural insights gained here improve our understanding of the regulation of HAI-1 inhibitory activities and point to new approaches for better controlling these activities.

  10. The present study demonstrated that ovarian cancer cell metastasis and invasion were more dependent on upregulation of matriptase levels than downregulation of HAI1. Matriptase may be a potential adjuvant therapeutic target for inhibiting ovarian cancer invasion and metastasis.

  11. provide new insight into the interplay between tertiary structure and the inhibitory activity of a multidomain protease inhibitor

  12. The findings suggest that the oncogenic activity of hepsin arises not only from elevated expression level but also from depletion of HAI-1, events which together trigger gain-of-function activity impacting HGF/MET signalling and epithelial cohesion

  13. it was found that the recombinant fusion protein uPA17-34-KPI (kunitz-type protease inhibitor ) inhibited the invasion and metastasis of ovarian tumors

  14. HAI-1 may have a critical role in maintaining normal keratinocyte morphology through regulation of PAR-2-dependent p38 mitogen-activated protein kinase signaling.

  15. the anti-migratory effects seen via gamma-catenin were driven by the expression of hepatocyte growth factor activator inhibitor Type I (HAI-1 or SPINT-1), an upstream inhibitor of the c-MET signaling pathway.

  16. Data suggest HAI1 exhibits structural features consistent with classification in MANEC subclass of PAN/apple domain family with unifying features such as two additional disulfide bonds, two extended loop regions, and additional alpha-helical elements.

  17. Matriptase activity was suppressed by the expression of HAI-1.

  18. The results of the present study identified HAI-1 as a favorable prognostic marker for prostate cancer and may indicate that HAI-1 could be a therapeutic target for the treatment of this malignancy.

  19. HAI-1 expression correlates with the differentiation status of colorectal epithelia and could serve as a differentiation marker.

  20. HAI-1 and HAI-2 influence proliferation and cell fate of NPCs and their expression levels are linked to BMP sign

Zebrafish serine Peptidase Inhibitor, Kunitz Type 1 (SPINT1) Interaktionspartner

  1. Results describe the live imaging of chronic inflammation caused by mutation of zebrafish Hai1.

serine Peptidase Inhibitor, Kunitz Type 1 (SPINT1) Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms.

Genbezeichner und Symbole assoziert mit SPINT1

  • serine peptidase inhibitor, Kunitz type 1 (SPINT1)
  • serine protease inhibitor, Kunitz type 1 (Spint1)
  • serine peptidase inhibitor, Kunitz type 1 (Spint1)
  • serine peptidase inhibitor, Kunitz type 1 a (spint1a)
  • cb376 Protein
  • HAI Protein
  • HAI-1 Protein
  • HAI1 Protein
  • MANSC2 Protein
  • sb:cb376 Protein
  • spint1l Protein
  • zgc:64075 Protein

Bezeichner auf Proteinebene für SPINT1

serine peptidase inhibitor, Kunitz type 1 , kunitz-type protease inhibitor 1 , kunitz-type protease inhibitor 1-like , hepatocyte growth factor activator inhibitor type 1 , hepatocyte growth factor activator inhibitor 1 , hepatocyte growth factor activator inhibitor-1 , serine protease inhibitor, Kunitz type 1 , HAI-1 , hai1a , serine peptidase inhibitor, Kunitz type 1 a , serine protease inhibitor HGFAI , serine protease inhibitor, Kunitz type 1 b

GENE ID SPEZIES
423206 Gallus gallus
487501 Canis lupus familiaris
534040 Bos taurus
704578 Macaca mulatta
100157387 Sus scrofa
100345098 Oryctolagus cuniculus
100473505 Ailuropoda melanoleuca
100585940 Nomascus leucogenys
20732 Mus musculus
311331 Rattus norvegicus
6692 Homo sapiens
100731222 Cavia porcellus
406426 Danio rerio
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