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ARHGEF26 encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an.
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The guanine-nucleotide exchange factor (zeige ARHGEF12 Antikörper) SGEF plays a crucial role in the formation of atherosclerosis.
Phenome-wide association scanning showed that CCDC92 likely affects coronary artery disease through insulin (zeige INS Antikörper) resistance pathways, whereas experimental analysis suggests that ARHGEF26 influences the transendothelial migration of leukocytes.
yrosine phosphorylation of SGEF suppresses its interaction with RhoG (zeige RHOG Antikörper), the elevation of RhoG (zeige RHOG Antikörper) activity, and SGEF-mediated promotion of cell migration. We identified tyrosine 530 (Y530), which is located within the Dbl (zeige MCF2 Antikörper) homology domain, as a major phosphorylation site of SGEF by Src (zeige SRC Antikörper), and Y530F mutation blocked the inhibitory effect of Src (zeige SRC Antikörper) on SGEF
Data support evidence for SGEF role in both the promotion of cell invasion and cell survival signaling within glioblastoma tumors and promoting chemotherapeutic resistance.
A novel function of SGEF that excludes GEF (zeige SLC2A4RG Antikörper).
We report for the first time an SGEF function for RhoG (zeige RHOG Antikörper) that excludes GEF (zeige SLC2A4RG Antikörper) and the ability of SGEF to enhance EGFR (zeige EGFR Antikörper) stability and signaling by delaying its lysosomal sorting and degradation
Data indicate that the Src (zeige SRC Antikörper) homology 3 domain-containing GEF (zeige SLC2A4RG Antikörper) (SGEF) promotes fibroblast growth factor-inducible 14 (zeige DDX3X Antikörper) (Fn14 (zeige TNFRSF12A Antikörper)) proinvasive signaling in glioblastoma via TNF receptor-associated factor 2 (TRAF2 (zeige TRAF2 Antikörper)).
SGEF is a novel promoter of human prostate cancer progression and development.
The invasive capacity of HPV transformed cells requires the hDlg-dependent enhancement of SGEF/RhoG activity.
SGEF gene on chromosome 3q25.2. CSGEF expression controlled by androgen-responsive promoter of SGEF gene. SGEF may be regulator of Rho guanosine triphosphatases. CSGEF may function as regulator of Rho guanosine triphosphatase in prostate
This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Src homology 3 domain-containing guanine nucleotide exchange factor
, rho guanine nucleotide exchange factor 26
, SH3 domain-containing guanine exchange factor