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Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. Zusätzlich bieten wir Ihnen GRAF Antikörper (91) und viele weitere Produktgruppen zu diesem Protein an.
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Human GRAF Protein expressed in Wheat germ - ABIN1345506
Jarius, Scharf, Begemann, Stöcker, Probst, Serysheva, Nagel, Graus, Psimaras, Wildemann, Komorowski: Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia. in Journal of neuroinflammation 2015
Show all 2 Pubmed References
GRAF1 plays a role in the maintenance of normal epithelial phenotype and its depletion leads to an epithelial-mesenchymal transition-like process that might be involved in neoplastic transformation.
We conclude that a transient interaction between Cdc42 (zeige CDC42 Proteine) and GRAF1 drives endocytic turnover and controls the transition essential for endosomal maturation of plasma membrane internalised by this mechanism.
GRAF expression is a favorable prognostic marker in patients with acute myeloid leukemia (zeige BCL11A Proteine).
ADAR1 (zeige ADAR Proteine) regulates the expression of ARHGAP26 through A-to-I RNA editing by disrupting the binding of miR (zeige MLXIP Proteine)-30b-3p and miR (zeige MLXIP Proteine)-573 within the 3' UTR of ARHGAP26.
proposed that GRAF1 remodels membrane microdomains at adhesion sites into endocytic carriers, facilitating membrane turnover during cell morphological changes
Findings suggest that the hypermethylation of GRAF promoter might be one of early events in the development of AML (zeige RUNX1 Proteine).
a GTPase-activating protein (zeige RASA1 Proteine) that regulates muscle maturation and to highlight the functional importance of BAR domains in myotube formation
Decreased level of GRAF transcript is associated with acute myeloid leukemia (zeige BCL11A Proteine), myelodysplastic syndrome and chronic myeloid leukemia (zeige BCL11A Proteine).
The GRAF gene was down-regulated in AML (zeige RUNX1 Proteine), which might play a role in the leukemogenesis.
The analysis of the expression pattern of the GRAF1/OPHN-1 (zeige OPHN1 Proteine)-L gene in human tissues and organs revealed the predominant brain expression of a novel splicing isoform.
GRAF1 and 2 facilitate myoblast fusion, at least in part, by promoting vesicle-mediated translocation of fusogenic ferlin proteins to the plasma membrane.
Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Two transcript variants encoding different isoforms have been found for this gene.
Rho GTPase activating protein 26
, rho GTPase-activating protein 26-like
, GTPase regulator associated with focal adhesion kinase pp125(FAK)
, oligophrenin-1-like protein
, rho GTPase-activating protein 26
, rho-type GTPase-activating protein 26
, GTPase regulator associated with focal adhesion kinase
, rhoGap protein