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RND3 encodes a protein which is a member of the small GTPase protein superfamily. Zusätzlich bieten wir Ihnen RND3 Antikörper (51) und und viele weitere Produktgruppen zu diesem Protein an.
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Human RND3 Protein expressed in HEK-293 Cells - ABIN2731005
Breslin, Daines, Doggett, Kurtz, Souza-Smith, Zhang, Wu, Yuan: Rnd3 as a Novel Target to Ameliorate Microvascular Leakage. in Journal of the American Heart Association 2016
TUG1 can epigenetically inhibit the level of RND3 through binding to EZH2 (zeige EZH2 Proteine), thus promoting pre-eclampsia development.
RND3 promotes Snail 1 (zeige SNAI1 Proteine) protein degradation in glioblastoma tumor cells, promoting cell migration and neoplasm invasiveness.
RhoE and ROCK2 (zeige ROCK2 Proteine) regulate chemoresistance in hepatocellular carcinoma.
This study Gene-based tests suggest evidence of association with related genes, ZEB2 (zeige ZEB2 Proteine), RND3, MCTP1, CTBP2 (zeige CTBP2 Proteine), and beta EEG.
plexin-B2 (zeige PLXNB2 Proteine) is a downstream target for Rnd3, which contributes to its cellular function.
Studies provide evidence that Rnd3 plays a dual role in cells; on one hand, it regulates cell proliferation, on the other hand, Rnd3 plays an important role in regulating metastasis and invasion. [review]
Our data supported that RhoE could inhibit cell proliferation and promote apoptosis. Moreover, these tumor-suppressing effects might be acted through the negative regulation of EGFR (zeige EGFR Proteine)/ERK (zeige EPHB2 Proteine) signaling.
constant degradation of RND3 by chaperone-mediated autophagy is required to sustain rapid proliferation of gastric cancer cells.
RhoA-ROCK-Rnd3 feedback loop determined the local reassembly sites of the actin cortex during membrane blebbing.
We conclude that downregulation of RND3 is responsible for the enhancement of Notch (zeige NOTCH1 Proteine) activity that promotes glioblastoma genesis.
Rnd3 acted as a novel proangiogenic factor involved in cardiac responsive angiogenesis through HIF1alpha (zeige HIF1A Proteine)-VEGFA (zeige VEGFA Proteine) signaling promotion.
These results indicate that RhoE plays a role in suppressing tumor initiation and progression.
Rnd3 is a novel factor involved in intracellular calcium homeostasis regulation in the heart.
Animals with Rnd3 haploinsufficiency are predisposed to hemodynamic stress. Hyperactivation of Rho kinase (zeige ROCK2 Proteine) activity is responsible in part for the apoptotic cardiomyopathy development.
Data show that the Plexin B2 (zeige PLXNB2 Proteine) receptor interacts physically and functionally with Rnd3 and stimulates RhoA (zeige RHOA Proteine) activity in migrating cortical neurons.
RhoE is indispensable for osteoclast migration and bone resorption by maintaining fast actin turnover in podosomes. RhoE activates podosome component cofilin (zeige CFL1 Proteine) by inhibiting its Rock-mediated phosphorylation.
although Rnd3 expression is controlled transcriptionally by Ascl1 (zeige ASCL1 Proteine), this proneural factor is itself required in radial glial progenitors only for proper orientation of cell divisions
Rnd3 is a regulator of Notch1 (zeige NOTCH1 Proteine) signaling
These findings support our previous report revealing the important role of RhoE in the normal development of the nervous system
the important role of Rnd3/RhoE in the normal development
This gene encodes a protein which is a member of the small GTPase protein superfamily. The encoded protein binds only GTP but has no GTPase activity, and appears to act as a negative regulator of cytoskeletal organization leading to loss of adhesion. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Rho family GTPase 3
, protein MemB
, ras homolog gene family, member E
, rho-related GTP-binding protein Rho8
, rho-related GTP-binding protein RhoE
, small GTP binding protein Rho8
, Rho related protein Rnd3/Rho8