PP4 (zeige ANXA5 ELISA Kits) regulates breast cancer cell survival and identifies a novel PP4c-PEA15 signalling axis in the control of breast cancer cell survival.
PEA15 expression was not significantly correlated with ovarian cancer antineoplastic drug resistance.
Data suggest the role of the phospholipase C epsilon (zeige PLCL1 ELISA Kits)-Protein kinase D (zeige PRKD1 ELISA Kits)-PEA15 protein-ribosomal S6 kinase (zeige RPS6KB1 ELISA Kits)-IkappaB-NF-kappa B (zeige NFKB1 ELISA Kits) pathway in facilitating inflammation and inflammation-associated carcinogenesis in the colon.
Integrin alpha5beta1 and p53 (zeige TP53 ELISA Kits) convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin (zeige BIRC5 ELISA Kits) in high-grade glioma.
High PED expression is associated with esophageal carcinoma.
The nuclear translocation of SApErk1/ 2 apart from PEA-15 as an important mechanism to reverse senescence phenotype.
Latent HCMV infection of CD34 (zeige CD34 ELISA Kits) + cells protects cells from FAS (zeige FAS ELISA Kits)-mediated apoptosis through the cellular IL-10 (zeige IL10 ELISA Kits)/PEA-15 pathway.
New therapeutic targets based around PEA-15 and its associated interactions are now being uncovered and could provide novel avenues for treatment strategies in multiple diseases.
PED/PEA-15 overexpression is sufficient to block hydrogen peroxide-induced apoptosis in Ins-1E cells through a PLD-1 mediated mechanism
Omi/HtrA2 (zeige HTRA2 ELISA Kits) overexpression promotes hepatocellular carcinoma cell apoptosis and the ped/pea-15 expression level causes this difference of the Omi/HtrA2 (zeige HTRA2 ELISA Kits) pro-apoptotic marker in the various hepatocellular carcinoma cell lines
Data suggest that PEA-15 contributes to the specification of the cytokine pattern of activated Th cells, thus highlighting a potential new target to interfere with T cell functional polarization and subsequent immune response.
PED/PEA-15 overexpression is sufficient to block hydrogen peroxide-induced apoptosis in Ins-1E cells through a PLD-1 mediated mechanism
Activated astrocytes are known to clear the Abeta (zeige APP ELISA Kits) deposited in the extracellular milieu, which is why they play a key role in regulating the progression of Alzheimer's disease (AD).
Activation of peroxisome proliferator-activated receptor-gamma (PPARgamma (zeige PPARG ELISA Kits)) represses transcription of the ped/pea-15 gene.
The findings revealed a novel mechanism by which PEA-15 positively regulates Ras/ERK signaling and increases the proliferation of H-Ras-transformed epithelial cells through enhanced phospholipase D1 expression and activation.
PEA-15 did not differentiate and showed markedly enhanced autophagy. In these same cells, the autophagy inhibitor 3-methyladenine rescued TGF-beta1 (zeige TGFB1 ELISA Kits) effect on both autophagy and myogenesis, indicating that PEA-15 mediates TGF-beta1 (zeige TGFB1 ELISA Kits) effects in muscle.
Data suggest that PED/PEA-15 may affect fibroblast motility by a mechanism, at least in part, mediated by ERK1/2 (zeige MAPK1/3 ELISA Kits).
we propose that PEA-15 represents a novel point of convergence of the protein kinas C and MAPK/ERK (zeige MAPK1 ELISA Kits) pathways under gonadotropin releasing hormone stimulation
PEA-15 regulates T-cell proliferation
PEA-15 inhibits tumorigenesis in an MDA-MB-468 triple-negative breast cancer xenograft model through increased cytoplasmic localization of activated extracellular signal-regulated kinase.
This gene encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C. Studies using knockout mice suggest that this protein may protect astrocytes from TNF-induced apoptosis. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake.
15 kDa phosphoprotein enriched in astrocytes , Phosphoprotein enriched in astrocytes, 15kD , astrocytic phosphoprotein PEA-15 , homolog of mouse MAT-1 oncogene , phosphoprotein enriched in diabetes , mammary transforming gene 1 , phosphoprotein enriched in astrocytes 15 , phosphoprotein enriched in astrocytes 15A , Astrocytic phosphoprotein PEA-15
GENE ID | SPEZIES |
---|---|
8682 | Homo sapiens |
18611 | Mus musculus |
364052 | Rattus norvegicus |
510586 | Bos taurus |
610113 | Canis lupus familiaris |
705026 | Macaca mulatta |
734852 | Xenopus laevis |
100145359 | Xenopus (Silurana) tropicalis |
100152480 | Sus scrofa |
100174153 | Pongo abelii |
100286636 | Salmo salar |
100730336 | Cavia porcellus |
557745 | Danio rerio |