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The PFKP gene encodes the platelet isoform of phosphofructokinase (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 22.214.171.124). Zusätzlich bieten wir Ihnen PFKP Antikörper (127) und PFKP Kits (41) und viele weitere Produktgruppen zu diesem Protein an.
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Snail functions as a metabolic switch between aerobic glycolysis and pentose phosphate pathway by repressing PFKP, a cancer-specific PFK-1, allowing cancer cell survival under metabolic stress.
Here the authors show that PFK1 (zeige PFKM Proteine) platelet isoform is upregulated in Glioblastoma and is required for tumor growth mechanistically, such upregulation is due to an increased stability induced by AKT (zeige AKT1 Proteine) activation via phosphorylation on residue S386.
Data indicate that platelet isoform of phosphofructokinase (PFKP) not only is required for metabolic reprogramming and maintaining cell proliferation, but also may be a valid target for anti-renal cancer pharmaceutical agents.
The crystallized PFKP is permanently activated by a deletion of the 22 C-terminal residues.
Anti-human protein S antibody induces tissue factor expression through a direct interaction with PFKP and ERK1/2 activation in coronary artery endothelial cells.
expression of TARDBP (zeige TARDBP Proteine) is significantly elevated in HCC (zeige FAM126A Proteine) and it regulates the expression of PFKP, the rate-limiting enzyme for glycolysis, through negative regulation of microRNA 520s (miR (zeige MLXIP Proteine)-520s).
KLF4 (zeige KLF4 Proteine) plays a role in maintenance of high glycolytic metabolism by transcriptional activation of the PFKP gene in breast cancer cells.
PFKP was identified using a trifunctional phenyl sulfonate probe.
Two phosphofructokinase (PFK) chimeras were constructed by exchanging the N- and C-terminal halves of the mammalian M- and C-type isozymes.
PFKP polymorphisms play no apparent role in the development of common forms of obesity in the Danish population.
The PFKP gene encodes the platelet isoform of phosphofructokinase (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 126.96.36.199). PFK catalyzes the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate and is a key regulatory enzyme in glycolysis. The PFKP gene, which maps to chromosome 10p, is also expressed in fibroblasts. See also the muscle (PFKM\; MIM 610681) and liver (PFKL\; MIM 171860) isoforms of phosphofructokinase, which map to chromosomes 12q13 and 21q22, respectively. Vora (1981)
, 6-phosphofructokinase type C
, phosphofructo-1-kinase isozyme C
, phosphofructokinase 1
, 6-phosphofructokinase, platelet type
, Phosphofructokinase, platelet type
, ATP:D-fructose 6-phosphate 1-phosphotransferase
, 6-phosphofructo-1-kinase, C-type
, phosphofructokinase C isozyme
, phosphofructokinase, muscle