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Acts as a GTP specific dissociation inhibitor (GDI). Zusätzlich bieten wir Ihnen phosphodiesterase 6D, CGMP-Specific, Rod, delta Antikörper (39) und viele weitere Produktgruppen zu diesem Protein an.
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PDE6delta binds selectively to the C-terminus of RPGR (zeige RPGR Proteine) and that this interaction is critical for RPGR's localization to cilia.
Studies indicate that the binding of UNC119 (zeige UNC119 Proteine) and PDE6D, to the lipid-modified ciliary cargo and the specific release of the cargo in the cilia by the ciliary small G-protein (zeige RAC2 Proteine) Arl3 in a GTP (zeige AK3 Proteine)-dependent manner.
Study identifies PDE6D as a novel Joubert syndrome gene and provides the first evidence of prenyl-binding-dependent trafficking in ciliopathies.
RPGR is acting as a scaffold protein recruiting cargo-loaded PDE6D and Arl3 to release lipidated cargo into cilia.
findings indicate that ARL13B (zeige ARL13B Proteine), INPP5E, PDE6D, and CEP164 form a distinct functional network that is involved in JBTS and NPHP but independent of the ones previously defined by NPHP and MKS (zeige MKS1 Proteine) proteins
Data show that PDEdelta activity augments K/Hras signalling by enriching Ras at the plasma membrane.
Results suggest that PrBP/delta exclusively interacts with the soluble fraction of PDE6.
The modest levels of basal activity exhibited by PDE6 purified from bovine rod outer segments (ROS (zeige ROS1 Proteine)) indicate that the inhibitory gamma subunit of PDE6 may not be tightly bound to PDE6 catalytic sites.
the affinity to PDE6delta and the release by Arl2 (zeige ARL2 Proteine)/3 in addition to a retention signal are the determinants for cargo sorting and enrichment at its destination.
Knockout of Unc119 (zeige UNC119 Proteine) partially reversed the transport defect of GRK1 (zeige GRK1 Proteine) in cone photoreceptors caused by deletion of Pde6d.
absence of PrBP/delta in retina impairs transport of prenylated proteins, particularly rhodopsin kinase (zeige GRK1 Proteine) 1 and cone PDE (zeige TWIST1 Proteine), to rod and cone outer segments
Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity).
retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
, phosphodiesterase 6D, cGMP-specific, rod, delta
, Retinal rod rhodopsin-sensitive cGMP 3,5-cyclic phosphodiesterase subunit delta
, phosphodiesterase 6D
, GMP-PDE delta
, protein p17
, cGMP-phosphodiesterase delta subunit
, pde6D gene for cGMP-phosphodiesterase delta subunit