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Acts as a GTP specific dissociation inhibitor (GDI). Zusätzlich bieten wir Ihnen phosphodiesterase 6D, CGMP-Specific, Rod, delta Antikörper (39) und viele weitere Produktgruppen zu diesem Protein an.
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PDE6delta binds selectively to the C-terminus of RPGR and that this interaction is critical for RPGR's localization to cilia.
Studies indicate that the binding of UNC119 and PDE6D, to the lipid-modified ciliary cargo and the specific release of the cargo in the cilia by the ciliary small G-protein Arl3 in a GTP-dependent manner.
Study identifies PDE6D as a novel Joubert syndrome gene and provides the first evidence of prenyl-binding-dependent trafficking in ciliopathies.
RPGR is acting as a scaffold protein recruiting cargo-loaded PDE6D and Arl3 to release lipidated cargo into cilia.
findings indicate that ARL13B, INPP5E, PDE6D, and CEP164 form a distinct functional network that is involved in JBTS and NPHP but independent of the ones previously defined by NPHP and MKS proteins
Data show that PDEdelta activity augments K/Hras signalling by enriching Ras at the plasma membrane.
Results suggest that PrBP/delta exclusively interacts with the soluble fraction of PDE6.
The modest levels of basal activity exhibited by PDE6 purified from bovine rod outer segments (ROS) indicate that the inhibitory gamma subunit of PDE6 may not be tightly bound to PDE6 catalytic sites.
PDEdelta functions as a prenyl-binding protein interacting with multiple prenylated proteins in retinal rods.
Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity).
retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
, phosphodiesterase 6D, cGMP-specific, rod, delta
, Retinal rod rhodopsin-sensitive cGMP 3,5-cyclic phosphodiesterase subunit delta
, phosphodiesterase 6D
, GMP-PDE delta
, protein p17
, cGMP-phosphodiesterase delta subunit
, pde6D gene for cGMP-phosphodiesterase delta subunit