alpha Hemoglobin Stabilizing Protein (aHSP) ELISA Kits

Act as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Zusätzlich bieten wir Ihnen aHSP Antikörper (54) und aHSP Proteine (16) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
aHSP 51327 Q9NZD4
aHSP 170812 Q9CY02
aHSP 293522  
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Top aHSP ELISA Kits auf antikoerper-online.de

Showing 9 out of 27 products:

Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 13.3 pg/mL 31.2 pg/mL - 2000 pg/mL 96 Tests Anmelden zum Anzeigen 13 bis 16 Tage
$663.16
Details
Maus
  96 Tests Anmelden zum Anzeigen 2 bis 3 Tage
$713.90
Details
Huhn 0.094 ng/mL 0.156-10 ng/mL   96 Tests Anmelden zum Anzeigen 12 bis 14 Tage
$715.00
Details
Kaninchen 37.5 pg/mL 62.5-4000 pg/mL   96 Tests Anmelden zum Anzeigen 12 bis 14 Tage
$715.00
Details
Schwein 0.094 ng/mL 0.156-10 ng/mL   96 Tests Anmelden zum Anzeigen 12 bis 14 Tage
$715.00
Details
Meerschweinchen 0.094 ng/mL 0.156-10 ng/mL   96 Tests Anmelden zum Anzeigen 12 bis 14 Tage
$715.00
Details
Affe 0.094 ng/mL 0.156-10 ng/mL   96 Tests Anmelden zum Anzeigen 12 bis 14 Tage
$715.00
Details
Ratte < 0.57 ng/mL 1.56 ng/mL - 100 ng/mL   96 Tests Anmelden zum Anzeigen 11 bis 18 Tage
$810.17
Details
Rind (Kuh)
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$1,029.60
Details

Weitere ELISA Kits für aHSP Interaktionspartner

Human alpha Hemoglobin Stabilizing Protein (aHSP) Interaktionspartner

  1. In the presence of free alpha subunits and H2O2, both HbA and HbE showed bCys93 oxidation which increased with higher H2O2 concentrations. In the presence of Alpha-hemoglobin stabilizing protein (AHSP)Cys93 oxidation was substantially reduced in both proteins.in the presence of excess free alpha-subunit and under the same oxidative conditions, these events are substantially increased for HbE compared to HbA

  2. Findings indicate that alpha-hemoglobin-stabilizing protein (AHSP) expression is a biomarker of hemoglobin H (HbH) disease severity and infer an important role of AHSP in modulating the pathophysiology of this disease.

  3. AHSP is predominantly expressed in erythroid precursors in bone marrow biopsy specimens from patients with hematologic malignancies.

  4. AHSP expression was higher in patients with sickle cell anemia versus thalassemia, with no significant difference between BTM and BTI. Expression was higher in patients with NTDT and on hydroxyurea therapy.

  5. In maturing RBC progenitors AHSP bind to free alpha-globin chains to increase the HbA production. (Review)

  6. analysis showed binding of STAT3 to AHSP promoter and binding was significantly augmented with IL6 stimulation and upon alpha-globin overexpression

  7. The relationship between AHSP gene expression, disease severity, and the beta/alpha globin mRNA ratio was studied among different homozygote beta-thalassemia patients.

  8. alpha-Hemoglobin-stabilizing protein (AHSP) perturbs the proximal heme pocket of oxy-alpha-hemoglobin and weakens the iron-oxygen bond.

  9. alpha-Hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of alpha-subunits of human HbA with hydrogen peroxide.

  10. AHSP acts as a molecular chaperone by rapidly binding and stabilizing met-alpha hemichrome folding intermediates

  11. AHSP could be a secondary compensatory mechanism in red blood cells to counterbalance the excess of alpha-globin chains in HbE/beta-thalassaemia individuals.

  12. NF-E2 may play an important role in AHSP gene regulation, providing new insights into the molecular mechanisms underlying the erythroid-specific expression of AHSP as well as new possibilities for beta-thalassemia treatment

  13. No significant association has been found between specific AHSP alleles or haplotypes and the disease severity of beta-thalassemia. Our study suggested that AHSP is not a significant genetic modifier of beta-thalassemia in southern China.

  14. Overexpression of human AHSP & 2 mutant versions with AA substitutions confering 3- or 13-fold higher affinity for alpha-globin had no major effects on hematologic parameters in beta-thalassemic mice.

  15. analysis of the action of a human mutant, AHSPV56G, of alpha-hemoglobin stabilizing protein (AHSP)

  16. Studies indicate that the interaction of alpha-Hb with AHSP involves surfaces normally employed in binding to beta-Hb.

  17. Different mechanisms may be responsible for the amount of abnormal Hb recovered, such as a highly unstable alpha chain or an impaired formation of the complex AHSP/alpha-Hb or a modification of the alphabeta dimer formation.

  18. An abundant erythroid protein that stabilizes free alpha-haemoglobin.

  19. determination as a predominantly alpha-helical globular protein with a somewhat asymmetric shape

  20. progesterone, corticotropin-releasing factor, and activin A have roles in paracrine regulation of endometrial function [review]

Mouse (Murine) alpha Hemoglobin Stabilizing Protein (aHSP) Interaktionspartner

  1. role of alpha-hemoglobin stabilizing protein in hemoglobin assembly

  2. Endogenous AHSP is not limiting for alpha-globin detoxification in beta-thalassemic mice.

  3. An abundant erythroid protein that stabilizes free alpha-haemoglobin.

  4. activin A does not appear to affect the exocrine or endocrine components of the pancreas, but promotes differentiation of pancreatic tissue into intestine via a Shh-dependent mechanism

  5. Loss of AHSP impairs erythropoiesis and exacerbates beta-thalassemia.

  6. These results support the hypothesis that EKLF acts as a transcription factor and a chromatin modulator for the AHSP and beta-globin genes and indicate that EKLF may play similar roles for other erythroid genes.

  7. developmental stage- and differentiation state-specific regulation of the nuclear transport of EKLF might be one of the steps necessary for the switch-on of the mammalian adult beta globin gene transcription

  8. AHSP also acts as a molecular chaperone to stabilize nascent alpha-globin for hemoglobin A assembly

  9. The expression of AHSP in a subclone of murine erythroleukemia cells in relationship to prion protein on the cell surface is reported.

aHSP Antigen-Profil

Beschreibung des Gens

Act as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation (By similarity).

Genbezeichner und Symbole assoziert mit aHSP

  • alpha hemoglobin stabilizing protein (AHSP) Antikörper
  • alpha hemoglobin stabilizing protein (Ahsp) Antikörper
  • alpha-hemoglobin-stabilizing protein-like (LOC100620111) Antikörper
  • AHSP Antikörper
  • EDRF Antikörper
  • Eraf Antikörper

Bezeichner auf Proteinebene für aHSP

alpha hemoglobin stabilizing protein , erythroid associated factor , alpha hemoglobin stabilising protein , alpha-hemoglobin-stabilizing protein , erythroid differentiation associated factor , erythroid differentiation-related factor , erythroid-associated factor

GENE ID SPEZIES
454073 Pan troglodytes
714392 Macaca mulatta
100127218 Ovis aries
100340962 Oryctolagus cuniculus
51327 Homo sapiens
170812 Mus musculus
338381 Bos taurus
293522 Rattus norvegicus
100712877 Cavia porcellus
100620111 Sus scrofa
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