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ZBTB7B encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. Zusätzlich bieten wir Ihnen Zinc Finger and BTB Domain Containing 7B Antikörper (87) und Zinc Finger and BTB Domain Containing 7B Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.
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a novel pathway by which TIP60 (zeige KAT5 ELISA Kits) and ThPOK synergistically suppresses Eomes (zeige EOMES ELISA Kits) function and IFNgamma production, which could contribute to the regulation of inflammation.
ThPOK may be considered a central regulator of the earliest events in the immune system during colorectal cancer development, decreasing the immune response against cancer cells.
The distal regulatory element (DRE (zeige SUFUH ELISA Kits)) in the Thpok gene also functions as a transcriptional enhancer, with DNA sequences specifically responsible for thymic enhancer activity.
ThPOK transgene stably represses CD8 (zeige CD8A ELISA Kits) gene expression through the deacetylation of Cd8 (zeige CD8A ELISA Kits) loci in CD4 (zeige CD4 ELISA Kits) cell lineage commitment.
The p65 (zeige GORASP1 ELISA Kits) subunit of NF-kappaB (zeige NFKB1 ELISA Kits) inhibits COL1A1 (zeige COL1A1 ELISA Kits) gene transcription in human dermal and scleroderma fibroblasts through its recruitment on promoter by protein interaction with transcriptional activators (c-Krox, Sp1 (zeige PSG1 ELISA Kits), and Sp3 (zeige SP3 ELISA Kits)).
impairment of Lck (zeige LCK ELISA Kits)-mediated CD4 (zeige CD4 ELISA Kits) coreceptor signaling by Nef is an important in vivo mechanism of HIV-1 pathogenesis
Thymoma neoplastic epithelial cells can induce Th-POK expression in T-cell subsets similarly to the normal thymic epithelial cells. In addition, there was no significant difference in Runx3 (zeige RUNX3 ELISA Kits) expression in T-cell subsets between normal thymi and thymomas.
These data suggest that the regulation of COL1A1 (zeige COL1A1 ELISA Kits) gene transcription in human dermal fibroblasts involves a complex machinery that implicates at least three transcription proteins, hc-Krox, Sp1 (zeige PSG1 ELISA Kits), and Sp3 (zeige SP3 ELISA Kits).
Chondroitin sulphate and its derived hydrolytic fragments (CSf (zeige CSF2 ELISA Kits)) repress COL1A1 (zeige COL1A1 ELISA Kits) gene transcription through a -112/-61 bp sequence upstream the start site of transcription and imply hc-Krox and Sp1 (zeige PSG1 ELISA Kits) transcription factors.
Runx and ThPOK role in mechanisms of lineage-specific gene regulation in the process of T-cell commitments[review]
this study shows that Thpok and LRF (zeige ZBTB7A ELISA Kits) are redundantly required to maintain the size and functions of the postthymic Treg pool
Together, these results suggest a novel mechanism regulating endothelial PATZ1 expression based on the down-regulation of miR-24 expression caused by hyperglycemia. Interfering with PATZ1 expression via miRNAs or miRNA mimics could potentially represent a new way to target endothelial PATZ1-dependent signaling of vascular dysfunction in diabetes.
Runx3 (zeige RUNX3 ELISA Kits) is crucial for the phenotypic and functional changes observed in ThPok-deficient invariant natural killer T cells.
present evidence that ectopic ThPOK expression gives rise to a preleukemic and self-perpetuating DN4 lymphoma precursor population
Data indicate that transcription factors Thpok and LRF (zeige ZBTB7A ELISA Kits) redundantly maintain CD4 (zeige CD4 ELISA Kits)+ lineage integrity.
induction of SOCS (zeige CISH ELISA Kits)-encoding genes is the main mechanism by which ThPOK imposes the CD4 (zeige CD4 ELISA Kits)(+) lineage fate in the thymus
The role of TCF-1 (zeige HNF1A ELISA Kits) and LEF-1 (zeige LEF1 ELISA Kits) in the CD4 (zeige CD4 ELISA Kits)-versus-CD8 (zeige CD8A ELISA Kits) lineage 'choice' was mediated in part by direct positive regulation of the transcription factor Th-POK
These findings imply that long-lasting T-cell receptor signals are needed to establish stable Thpok expression activity to commit to helper T-cell fate.
Gata3 (zeige GATA3 ELISA Kits) promotes Cd4 (zeige CD4 ELISA Kits) expression in Thpok-deficient thymocytes.
Data indicate that Valpha14 invariant natural killer T (Valpha14i NKT (zeige CTSL1 ELISA Kits)) cells from Th-POK-mutant helper deficient (hd/hd (zeige HTT ELISA Kits)) mice have increased transcripts of genes normally expressed by Th17 and NKT17 cells.
This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene.
T-helper-inducing POZ/Krueppel-like factor
, krueppel-related zinc finger protein cKrox
, zinc finger and BTB domain containing 15
, zinc finger and BTB domain-containing protein 7B
, zinc finger protein 67 homolog
, zinc finger protein 857B
, zinc finger protein Th-POK
, T helper-inducing POZ/Krueppel factor
, Vzinc finger and BTB domain containing 7B
, zinc finger protein 67
, zinc finger and BTB domain containing 7B
, kruppel-related zinc finger protein hcKrox