Zinc Finger Protein 36, C3H Type, Homolog (Mouse) Proteine (ZFP36)

mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Zusätzlich bieten wir Ihnen ZFP36 Antikörper (86) und ZFP36 Kits (11) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ZFP36 7538 P26651
Maus ZFP36 ZFP36 22695 P22893
Ratte ZFP36 ZFP36 79426 P47973
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Showing 3 out of 3 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,871.00
Details

ZFP36 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,

Am meisten referenzierte ZFP36 Proteine

  1. Human ZFP36 Protein expressed in Wheat germ - ABIN1325745 : McDermott, Ellis, Bou-Gharios, Clegg, Tew: RNA binding proteins regulate anabolic and catabolic gene expression in chondrocytes. in Osteoarthritis and cartilage 2016 (PubMed)

Weitere Proteine zu Zinc Finger Protein 36, C3H Type, Homolog (Mouse) (ZFP36) Interaktionspartnern

Human Zinc Finger Protein 36, C3H Type, Homolog (Mouse) (ZFP36) Interaktionspartner

  1. Overexpression of miRNA-29c in podocytes resulted in an increase in inflammatory cytokines and inhibition of miRNA-29c by using its inhibitor reduced the inflammatory cytokines in podocytes. Finally, miRNA-29c promoted the progression of diabetic nephropathy (DN) by targeting TTP, providing a target for a therapeutic intervention of DN.

  2. Data indicate that the angiopoietin-like protein 4 (ANGPTL4)-mediated upregulation of tristetraprolin expression regulates the stability of chemokines in human colon epithelial cells.

  3. PD-L1 is a critical TTP-regulated factor that contributes to inhibiting antitumor immunity.

  4. The role of TTP in human cancers and immunity.[review]

  5. Findings reveal tristetraprolin, which is known to bind COX-2 mRNA and promote its rapid degradation, as regulator of COX-2 expression in influenza A viruses (IAV) infection. During IAV replication and viral RNA accumulation TTP mRNA synthesis was induced, resulting in reduced COX-2 levels.

  6. our data demonstrate that TTP acts as a regulator of mitochondrial dynamics through enhancing degradation of alpha-Syn mRNA in cancer cells. This finding will increase understanding of the molecular basis of mitochondrial dynamics.

  7. Suggest that TTP is an important prognostic indicator for prostate cancer, and augmenting TTP function would effectively disable the metabolism and proliferation of aggressive prostate tumors.

  8. RAS signaling can upregulate tumor cell PD-L1 expression through a mechanism involving increases in PD-L1 mRNA stability via modulation of the AU-rich element-binding protein tristetraprolin.

  9. Because TTP also represses IL-1beta expression, it is a dual inhibitor of the IL-1beta system, regulating expression of the cytokine and the upstream controller NLRP3

  10. Data show that the synthetic liver X receptors (LXRs) agonist T0901317 promoted cytokines IL-1beta, IL-6 and TNFalpha mRNA degradation, destabilized TNFalpha mRNA through its 3'-untranslated region, and increased the expression of tristetraprolin (TTP).

  11. TTP was demonstrated to destabilize the VEGF mRNA in ARPE-19 cells under hypoxic conditions. Furthermore, CM from TTP-overexpressing ARPE-19 cells suppressed tube formation in HUVECs.

  12. this study shows that TTP is down-regulated in glioma tissue samples and cell lines, and is associated with diminished survival in glioma patients

  13. TTP inhibited the proliferation, migration, and invasion of gastric cancer cell lines through regulation of IL-33.

  14. Results suggest that ZFP36 proteins might control reepithelialization and angiogenesis in the skin in a multimodal manner.

  15. Our data offer the convincing evidence for the first time that the aberrant expressions of ZFP36 and SOCS3 may be involved into the progression and patients' prognosis of prostate cancer

  16. Low TTP expression is associated with epithelial-mesenchymal transition in cancer.

  17. PP2A activators boost the anti-inflammatory function of TTP and have implications for future pharmacotherapeutic strategies to combat inflammation in respiratory disease.

  18. The mRNA destabilizing activity of TTP was increased when the partially disordered RNA binding domain (RBD) of TTP was replaced with the fully structured RBD of TIS11d, indicating that differences in the folded state of the RBD affect the activity of the proteins in the cell.

  19. Tristetraprolin induces cell cycle arrest in breast tumor cells by targeting AP-1/c-Jun and NF-kappaB/RelA pathway.

  20. TTP-dependent regulatory pathway described herein likely contributes to the role of IL-22 in inflammation and cancer and may evolve as novel target for pharmacological IL-22 modulation.

Pig (Porcine) Zinc Finger Protein 36, C3H Type, Homolog (Mouse) (ZFP36) Interaktionspartner

  1. direct interaction between TTP protein and porcine TNF-alpha mRNA ARE probe

ZFP36 Protein Überblick

Protein Überblick

mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF).

Genbezeichner und Symbole assoziert mit ZFP36

  • ZFP36 ring finger protein (ZFP36)
  • ZFP36 ring finger protein L homeolog (zfp36.L)
  • tristetraproline (EDI_287240)
  • Tristetraproline (Bm1_42085)
  • tristetraproline (LOAG_03119)
  • similar to Tristetraproline (TTP) (Zinc finger protein 36 homolog) (Zfp-36) (TIS11A protein) (TIS11) (Growth (ZFP36)
  • ZFP36 ring finger protein (zfp36)
  • zinc finger protein 36 (Zfp36)
  • ZFP36 ring finger protein (Zfp36)
  • C3H-1 Protein
  • g0s24 Protein
  • Gos24 Protein
  • Nup475 Protein
  • rnf162a Protein
  • Tis11 Protein
  • TIS11D Protein
  • TISII Protein
  • Ttp Protein
  • Zfp-36 Protein
  • ZFP36 Protein

Bezeichner auf Proteinebene für ZFP36

G0/G1 switch regulatory protein 24 , growth factor-inducible nuclear protein NUP475 , tristetraprolin , tristetraproline , zinc finger protein 36 homolog , zinc finger protein 36, C3H type, homolog , zinc finger protein, C3H type, 36 homolog , CCCH zinc finger protein C3H-1 , Tristetraproline , TIS11 , TTP , zfp-36 , zinc finger protein homologous to Zfp-36 in mouse , similar to Tristetraproline (TTP) (Zinc finger protein 36 homolog) (Zfp-36) (TIS11A protein) (TIS11) (Growth , zinc finger protein 36, C3H type, homolog (mouse) , CCCH (CX8CX5CX3H) zinc finger domain RNA-binding protein , TPA-induced sequence 11 , TNF alpha inhibitor , Tax interacting protein

GENE ID SPEZIES
7538 Homo sapiens
398102 Xenopus laevis
5879635 Entamoeba dispar SAW760
6103302 Brugia malayi
9940506 Loa loa
282127 Bos taurus
698280 Macaca mulatta
736203 Pan troglodytes
100127733 Xenopus (Silurana) tropicalis
100316849 Sus scrofa
22695 Mus musculus
79426 Rattus norvegicus
484510 Canis lupus familiaris
443283 Ovis aries
100733110 Cavia porcellus
100340391 Oryctolagus cuniculus
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