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Function as a transcriptional repressor for PRDM1 (By similarity).. Zusätzlich bieten wir Ihnen Zinc Finger Protein 340 Antikörper (55) und und viele weitere Produktgruppen zu diesem Protein an.
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Authors report a novel tumor promoter, ZBTB46, which is negatively regulated by AR signaling via microRNA (miR)-1 (zeige FSD1 Proteine)-mediated downregulation. ZBTB46 is associated with malignant prostate cancer and is essential for metastasis.
A single nucleotide polymorphisn in ZBTB46, rs6062314, is associated with an increased genetic risk for multiple sclerosis.
Zbtb46 is a repressor of a transcriptional network that is extinguished upon immune stimulation by TLR ligands. This network is in part responsible for maintaining dendritic cells quiescence in the steady state.
Zbtb46 may help enforce dendritic cell identity by restricting responsiveness to non-dendritic cells growth factors and may serve as a useful marker to identify rare dendritic cell progenitors
expression of the Btbd4 defines the classical dendritic cell lineage
Function as a transcriptional repressor for PRDM1 (By similarity).
BTB (POZ) domain containing 4
, BTB-ZF protein expressed in effector lymphocytes
, BTB/POZ domain-containing protein 4
, zinc finger and BTB domain-containing protein 46
, zinc finger protein 340