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May be involved in transcriptional regulation..
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The analyses using human breast ductal carcinoma tissues exhibited that the expression of ZNF224 and miR (zeige MLXIP Proteine)-663a was increased in cancer compared to non-cancer region.
we showed that ZNF224 positively modulates cyclin D3 (zeige CCND3 Proteine) gene expression. Consistently, we observed that alteration of ZNF224 expression leads to defects in cell cycle control. All together, our results strongly suggest that in Chronic lymphocytic leukaemia (CLL)cells high expression level of ZNF224 can lead to inappropriate cell growth and apoptosis resistance, thus contributing to CLL progression
Increasing information on the mechanism through which ZNF224 can operate could lead to the identification of agents capable of modulating ZNF224 function, thus potentially paving the way to new therapeutic strategies for treatment of cancer
Data show that Wilms' tumor 1 (zeige WT1 Proteine) protein (WT1 (zeige WT1 Proteine))binds to the zinc finger protein 224 (ZNF224) promoter and represses ZNF224 expression.
ZNF224 acts in fine tuning of WT1 (zeige WT1 Proteine)-dependent control of gene expression, acting as a co-activator of WT1 (zeige WT1 Proteine) in the regulation of proapoptotic genes and suppressing WT1 (zeige WT1 Proteine) mediated transactivation of antiapoptotitc genes.
REVIEW: ZNF224 is a multifunctional protein and alternative splicing, sub-cellular compartmentalization and isoform-specific interactions may modulate its activity
ZNF224 acts as a transcriptional co-regulator of WT1 (zeige WT1 Proteine).
Coimmunoprecipitation and immunocytochemistry revealed that DEPDC1 (zeige DEPDC1 Proteine) interacted and colocalized with zinc finger transcription factor (zeige OSR1 Proteine) ZNF224, a known transcriptional repressor.
Results suggest that bone marrow zinc finger 2 (BMZF2) interferes with the transactivation potential of Wilms tumor suppressor gene (WT1 (zeige WT1 Proteine)).
We demonstrate that ZNF224, a Kruppel-like zinc finger transcription factor, is the repressor protein that specifically binds to the negative cis-element AldA-NRE and affects the AldA-NRE-mediated transcription
May be involved in transcriptional regulation.
bone marrow zinc finger 2
, zinc finger 2, bone marrow
, zinc finger protein 233
, zinc finger protein 255
, zinc finger protein 27 (KOX 22)
, zinc finger protein KOX22
, zinc finger protein ZNF255
, protein mKR4