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ZC3H14 belongs to a family of poly(A)-binding proteins that influence gene expression by regulating mRNA stability, nuclear export, and translation (Kelly et al., 2007 [PubMed 17630287]).[supplied by OMIM, Mar 2010].. Zusätzlich bieten wir Ihnen ZC3H14 Antikörper (39) und viele weitere Produktgruppen zu diesem Protein an.
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Study identified sut-2 as a gene required for tau neurotoxicity in C. elegans and cloned the sut-2 gene and found it encodes a novel sub-type of CCCH zinc finger protein conserved across animal phyla.
Among the proteins increased in the hippocampi of Zc3h14Deltaex13/Deltaex13 mice compared to control are key synaptic proteins including CaMK2a (zeige CAMK2A Proteine). This newly generated mouse serves as a tool to study the function of ZC3H14 in vivo.
ATP5G1 (zeige ATP5G1 Proteine) turnover increases upon depletion of ZC3H14, double knockdown of ZC3H14 and the nonsense-mediated decay factor, UPF1 (zeige UPF1 Proteine), rescues ATP5G1 (zeige ATP5G1 Proteine) transcript levels. Furthermore, fractionation reveals an increase in the amount of ATP5G1 (zeige ATP5G1 Proteine) pre-mRNA that reaches the cytoplasm when ZC3H14 is depleted and that ZC3H14 binds to ATP5G1 (zeige ATP5G1 Proteine) pre-mRNA in the nucleus.
we show here that human ZC3H14 can functionally substitute for dNab2 in fly neurons and can rescue defects in development and locomotion that are present in dNab2 null flies
report a intellectual disability disease locus on chromosome 14q31.3 corresponding to mutation of the ZC3H14 gene that encodes a conserved polyadenosine RNA binding protein
MSUT2 levels may influence neuronal vulnerability to tau toxicity and aggregation.
New neuroprotective strategies targeting MSUT-2 that may be effective in modulating tau neurotoxicity in human tauopathy disorders.
multiple transcripts encoding several ZC3H14 isoforms exist in vivo
ZC3H14 belongs to a family of poly(A)-binding proteins that influence gene expression by regulating mRNA stability, nuclear export, and translation (Kelly et al., 2007
zinc finger CCCH domain-containing protein 14
, zinc finger CCCH-type containing 14
, nuclear protein UKp68
, nuclear protein UKp83/UKp68
, mammalian suppressor of tau pathology-2
, renal carcinoma antigen NY-REN-37