Wolf-Hirschhorn Syndrome Candidate 1 Proteine (WHSC1)

WHSC1 encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. Zusätzlich bieten wir Ihnen WHSC1 Antikörper (44) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
WHSC1 7468 O96028
Ratte WHSC1 WHSC1 680537  
WHSC1 107823 Q8BVE8
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Showing 5 out of 5 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
Details
Wheat germ Human GST tag 10 μg 11 bis 12 Tage
$414.29
Details
Escherichia coli (E. coli) Human GST tag MMSET / WHSC1 - SET activity assay using Recombinant Nucleosomes as substrates. Recombinant Nucleosomes were used as substrates in an assay measuring the methyltransferase activity of MMSET / WHSC1 - SET. Activity was detected by fluorography. Recombinant MMSET / WHSC1 - SET protein gel. Recombinant MMSET / WHSC1 - SET run on an SDS-PAGE gel and stained with Coomassie blue. 50 μg 1 bis 2 Tage
$478.33
Details
Baculovirus Human DYKDDDDK Tag MMSET / WHSC1 activity assay. HMT assay measuring the activity of Recombinant MMSET / WHSC1. Activity was detected by fluorography. Recombinant MMSET / WHSC1 protein gel. MMSET / WHSC1 protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. 20 μg 1 bis 2 Tage
$478.33
Details

WHSC1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, ,
Mouse (Murine)

Weitere Proteine zu Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) Interaktionspartnern

Zebrafish Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) Interaktionspartner

  1. These results indicate that DrWhsc1 is a functional homolog of WHSC1 and that the SET domain of DrWhsc1 is essential for di-methylation of histone H3K36 in zebrafish.

Human Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) Interaktionspartner

  1. Study provides evidence that WHSC1 overexpression in ovarian clear cell carcinoma (OCCC) induces cell growth and its expression is, at least in part, regulated by EZH2.

  2. CCND1, NSD2, and MAF gene rearrangements were estimated accurately by IHC, suggesting that conventional FISH assays can be replaced by IHC.

  3. Study found that WHSC1 expression was up-regulated in human salivary adenoid cystic carcinoma (SACC) tissues. WHSC1 knockdown significantly inhibited cell proliferation, and increased apoptosis in SACC cells.

  4. GLO1 may be of functional importance target downstream of MMSET I.

  5. Our study expands the list of microdeletion syndromes that are solved at the single-gene level, and establishes WHSC1 as a disease gene in humans.

  6. miR-154 inhibits proliferation and induces apoptosis of human skin SCC cells by down-regulating WHSC1 and blocking the P53 signaling pathway

  7. WHSC1 mutation is associated with growth delay, intellectual disability, and to the facial dysmorphism.

  8. Transcriptional profiling demonstrates that mutant NSD2 aberrantly activates factors commonly associated with neural and stromal lineages in addition to signaling and adhesion genes. Identification of these pathways provides new avenues for therapeutic interventions in NSD2 dysregulated malignancies.

  9. MMSET is a regulator of p53 stability via methylation of AURKA in proliferating cells.

  10. NSD2 is a driver of metastatic prostate cancer progression.

  11. Mutations in NSD1 or NSD2 are independent favorable prognostic biomarkers for laryngeal cancer.

  12. The MMSET is required for efficient NER and that it catalyzes the dimethylation of histone H4 at lysine 20 (H4K20me2).

  13. NSD2 promoted the proliferation of pancreatic beta cell lines. Moreover, ectopic expression of NSD2 significantly promoted insulin secretion. In addition, NSD2 served as a transfection factor and it was identified that NSD2 transcriptionally regulated PDX1 expression through its H3K36me2 methyltransferase activity.

  14. Herein we report on the first fully validated WHSC1 inhibitor, PTD2, a norleucine-containing peptide derived from the histone H4 sequence. This peptide exhibits micromolar affinity towards WHSC1 in biochemical and biophysical assays. Furthermore, a crystal structure was solved with the peptide in complex with SAM and the SET domain of WHSC1L1

  15. The histone methyltransferase NSD2/WHSC1/MMSET is overexpressed in a number of solid tumors but its contribution to the biology of these tumors is not well understood. Here, we describe that NSD2 contributes to the proliferation of a subset of lung cancer cell lines by supporting oncogenic RAS transcriptional responses.

  16. MMSET-like gene signature captures a subset of high-risk myeloma patients underrepresented by conventional risk stratification platforms and defines a distinct biologic subtype.

  17. These findings indicate that the miR-2392-MAML3/WHSC1-Slug/Twist1 regulatory axis plays a critical role in GC metastasis.

  18. In a murine xenograft model using t(4;14)+ KMS11 MM cells harboring an inducible MMSET shRNA, depletion of MMSET enhanced the efficacy of chemotherapy, inhibiting tumor growth and extending survival.

  19. data suggest multiple myeloma SET domain containing protein(MMSET) may play a role in the inhibitory effect of metformin on prostate cancer and could serve as a potential novel therapeutic target for prostate cancer

  20. NSD2 overexpression is significantly associated with high risk of relapse and poor survival in tamoxifen-treated ER-positive breast cancer patients via coordinated activation of pentose phosphate pathway enzymes.

Mouse (Murine) Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) Interaktionspartner

  1. SPT6 recruitment is abrogated in cells lacking the histone methyltransferase NSD2. SPT6 interacts with NSD2.

  2. NSD2 is a driver of metastatic prostate cancer progression.

  3. Results suggest a critical role of histone-lysine N-methyltransferase Nsd2-mediated histone H3K36 methylation in adipose tissue development and function.

  4. MMSET promotes AICDA-mediated DNA breaks at the donor switch region during immunoglobulin class switch recombination.

  5. Whsc1 plays an important role at several points of hematopoietic development.

  6. findings highlight a pivotal link between an epigenetic regulator, WHSC1, and key intracellular signaling molecules, AKT, RICTOR, and Rac1, to drive prostate cancer metastasis.

  7. WHSC1-deficient mice display craniofacial defects that overlap with Wolf-Hirschhorn syndrome, including cochlea anomalies

  8. Histone H3 lysine 36 methyltransferase Whsc1 promotes the association of Runx2 and p300 in the activation of bone-related genes

  9. all of the H3K36-specific methyltransferases, including ASH1L, HYPB, NSD1, and NSD2 were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a, and Pr-Set7 were not affected by ubH2A.

  10. WHSC1 links transcription elongation to HIRA-mediated histone H3.3 deposition.

  11. H3K36me3-specific histone methyltransferase WHSC1 (also NSD2 or MMSET) functions in transcriptional regulation together with developmental transcription factors whose defects overlap with the human disease Wolf-Hirschhorn syndrome

WHSC1 Protein Überblick

Protein Überblick

This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4\;14)(p16.3\;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences.

Genbezeichner und Symbole assoziert mit WHSC1

  • nuclear receptor binding SET domain protein 2 (NSD2)
  • nuclear receptor binding SET domain protein 2 (nsd2)
  • Wolf-Hirschhorn syndrome candidate 1 (WHSC1)
  • nuclear receptor binding SET domain protein 2 (Nsd2)
  • 5830445G22Rik Protein
  • 9430010A17Rik Protein
  • AW555663 Protein
  • C130020C13Rik Protein
  • D030027O06Rik Protein
  • D930023B08Rik Protein
  • fc12c04 Protein
  • mKIAA1090 Protein
  • MMSET Protein
  • NSD2 Protein
  • REIIBP Protein
  • RGD1565590 Protein
  • si:rp71-77d7.2 Protein
  • TRX5 Protein
  • WHS Protein
  • WHSC1 Protein
  • Whsc1l Protein
  • wu:fc12c04 Protein
  • wu:fi20c01 Protein

Bezeichner auf Proteinebene für WHSC1

Wolf-Hirschhorn syndrome candidate 1 protein , Wolf-Hirschhorn syndrome candidate 1 , probable histone-lysine N-methyltransferase NSD2 , IL5 promoter REII region-binding protein , histone-lysine N-methyltransferase NSD2 , multiple myeloma SET domain containing protein type III , nuclear SET domain-containing protein 2 , trithorax/ash1-related protein 5 , multiple myeloma SET domain-containing protein , wolf-Hirschhorn syndrome candidate 1 protein homolog

GENE ID SPEZIES
461070 Pan troglodytes
540769 Bos taurus
100000709 Danio rerio
100051090 Equus caballus
100125213 Xenopus (Silurana) tropicalis
479077 Canis lupus familiaris
7468 Homo sapiens
422897 Gallus gallus
680537 Rattus norvegicus
107823 Mus musculus
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