anti-Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) Antikörper

WHSC1 encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. Zusätzlich bieten wir Ihnen WHSC1 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
WHSC1 7468 O96028
WHSC1 680537  
WHSC1 107823 Q8BVE8
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Top anti-WHSC1 Antikörper auf

Showing 10 out of 45 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Hund Kaninchen Unkonjugiert WB <b>WB Suggested Anti-WHSC1 Antibody Titration: </b>0.2-1 ug/ml<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
Human Maus Unkonjugiert ChIPSeq, ChIP, ICC, IF, WB MMSET / WHSC1 antibody (mAb) tested by ChIP-Seq. ChIP was performed using the ChIP-IT® High Sensitivity Kit (Cat. No. 53040) with chromatin from a human multiple myeloma cell line (4.5 million cells) and 10 µl of antibody. ChIP DNA was sequenced on the Illumina HiSeq and 23 million sequence tags were mapped to identify MMSET binding patterns. The panel on the left shows binding across 12 million bp on chromosome 12. The panel on the right is zoomed in to show individual peaks. MMSET / WHSC1 antibody (mAb) tested by immunofluorescence. Formaldehyde fixed HeLa cells stained with MMSET / WHSC1 antibody at a 0.5 µg/ml dilution. 100 μg Anmelden zum Anzeigen 1 bis 2 Tage
Human Kaninchen Unkonjugiert IHC (p), WB IHC-P Image Immunohistochemical analysis of paraffin-embedded A549 xenograft, using NSD2, antibody at 1:100 dilution. WB Image Sample(30 ug whole cell lysate) A:Raji , 5% SDS PAGE antibody diluted at 1:1000 100 μL Anmelden zum Anzeigen 1 bis 2 Tage
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p) Immunohistochemistry-Paraffin: WHSC1 Antibody  - Staining in human testis and liver tissues using anti-NSD2 antibody. Corresponding NSD2 RNA-seq data are presented for the same tissues. Immunohistochemistry-Paraffin: WHSC1 Antibody  - Staining of human liver shows low expression as expected. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
Human Kaninchen Unkonjugiert IHC, IHC (p), WB Western Blot: WHSC1 Antibody [NBP1-30910] - Sample(30 ug whole cell lysate)A:Raji (GTX27908)5% SDS PAGE, antibody diluted at 1:1000. Immunohistochemistry-Paraffin: WHSC1 Antibody [NBP1-30910] - Paraffin-embedded A549 xenograft, using antibody at 1:100 dilution. 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
Huhn Kaninchen Unkonjugiert IHC (p), WB Anti-WHSC1 / NSD2 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN1105042 dilution 38474 ug/ml. 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
Human Kaninchen Unkonjugiert WB WHSC1 Antibody (C-term)  western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the WHSC1 antibody detected the WHSC1 protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
Human Kaninchen Unkonjugiert IHC, WB Western blot analysis of extracts of various cells, using WHSC1 antibody. Immunohistochemistry of paraffin-embedded mouse lung using WHSC1 antibody at dilution of 1:100 (40x lens). 100 μL Anmelden zum Anzeigen 16 Days
Human Kaninchen Unkonjugiert ELISA, WB 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
Human Maus Unkonjugiert IF, WB Western Blot analysis of WHSC1 expression in transfected 293T cell line by WHSC1 MaxPab polyclonal antibody.<br><br>Lane1:WHSC1 transfected lysate(71.17 KDa).<br>Lane2:Non-transfected lysate.<br> Immunofluorescence of <u>purified</u> MaxPab antibody to WHSC1 on HeLa cell. [antibody concentration 10 ug/ml] 50 μg Anmelden zum Anzeigen 11 bis 12 Tage

WHSC1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Human , ,
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Rat (Rattus)

Mouse (Murine)

Am meisten referenzierte anti-WHSC1 Antikörper

  1. Human Polyclonal WHSC1 Primary Antibody für ICC, IF - ABIN4366102 : Toyokawa, Cho, Masuda, Yamane, Yoshimatsu, Hayami, Takawa, Iwai, Daigo, Tsuchiya, Tsunoda, Field, Kelly, Neal, Maehara, Ponder, Nakamura, Hamamoto: Histone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway. in Neoplasia (New York, N.Y.) 2011 (PubMed)
    Show all 3 Pubmed References

  2. Human Monoclonal WHSC1 Primary Antibody für ChIPSeq, ChIP - ABIN2668917 : Marango, Shimoyama, Nishio, Meyer, Min, Sirulnik, Martinez-Martinez, Chesi, Bergsagel, Zhou, Waxman, Leibovitch, Walsh, Licht: The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor. in Blood 2008 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal WHSC1 Primary Antibody für IF, WB - ABIN521379 : Huang, Wu, Chuai, Xu, Yan, Englund, Wang, Zhang, Fang, Wang, Gu, Zhang, Yang, Zhao, Yu, Dai, Yi, Zhou, Li, Wu, Liu, Wu, Chan, Lu, Atadja, Li, Wang, Hu: NSD2 is recruited through its PHD domain to oncogenic gene loci to drive multiple myeloma. in Cancer research 2013 (PubMed)

  4. Dog (Canine) Polyclonal WHSC1 Primary Antibody für WB - ABIN2777965 : Santra, Zhan, Tian, Barlogie, Shaughnessy: A subset of multiple myeloma harboring the t(4;14)(p16;q32) translocation lacks FGFR3 expression but maintains an IGH/MMSET fusion transcript. in Blood 2003 (PubMed)
    Show all 2 Pubmed References

Weitere Antikörper gegen WHSC1 Interaktionspartner

Zebrafish Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) Interaktionspartner

  1. These results indicate that DrWhsc1 is a functional homolog of WHSC1 and that the SET domain of DrWhsc1 is essential for di-methylation of histone H3K36 in zebrafish.

Human Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) Interaktionspartner

  1. MMSET-like gene signature captures a subset of high-risk myeloma patients underrepresented by conventional risk stratification platforms and defines a distinct biologic subtype.

  2. These findings indicate that the miR (zeige MLXIP Antikörper)-2392-MAML3 (zeige MAML3 Antikörper)/WHSC1-Slug/Twist1 (zeige TWIST1 Antikörper) regulatory axis plays a critical role in GC metastasis.

  3. In a murine xenograft model using t(4;14)+ KMS11 MM cells harboring an inducible MMSET shRNA, depletion of MMSET enhanced the efficacy of chemotherapy, inhibiting tumor growth and extending survival.

  4. data suggest multiple myeloma SET domain containing protein(MMSET) may play a role in the inhibitory effect of metformin on prostate cancer and could serve as a potential novel therapeutic target for prostate cancer

  5. NSD2 overexpression is significantly associated with high risk of relapse and poor survival in tamoxifen-treated ER-positive breast cancer patients via coordinated activation of pentose phosphate pathway enzymes.

  6. Results show that WHSC1 is hypomethylated in cervical cancer cells and tissues. Both methylation and mRNA expression of WHSC1 were significantly correlated with lymph node metastasis and the overall survival of patients.

  7. Results showed that high levels of MMSET in the myeloma-like cells drove the formation of hypermethyled proteoforms containing H3K36me2 co-existent with the repressive marks H3K9me2/3 and H3K27me2/3.

  8. In MMSET-depleted cells there are defects in DNA replication and a decreased association with chromatin.

  9. results identify a pivotal role for NSD2 binding to its catalytic product in regulating its cellular functions, and suggest a model for how this interaction may facilitate epigenetic spreading and propagation of H3K36me2.

  10. NSD2 preferentially catalyzes the dimethylation of H3K36 along with a reduced preference for H3K36 monomethylation

Mouse (Murine) Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) Interaktionspartner

  1. Whsc1 plays an important role at several points of hematopoietic development.

  2. findings highlight a pivotal link between an epigenetic regulator, WHSC1, and key intracellular signaling molecules, AKT, RICTOR, and Rac1, to drive prostate cancer metastasis.

  3. WHSC1-deficient mice display craniofacial defects that overlap with Wolf-Hirschhorn syndrome, including cochlea anomalies

  4. Histone H3 (zeige HIST3H3 Antikörper) lysine 36 methyltransferase Whsc1 promotes the association of Runx2 (zeige RUNX2 Antikörper) and p300 (zeige NOTCH1 Antikörper) in the activation of bone-related genes

  5. all of the H3K36-specific methyltransferases, including ASH1L (zeige ASH1L Antikörper), HYPB (zeige SETD2 Antikörper), NSD1 (zeige NSD1 Antikörper), and NSD2 were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a (zeige EHMT2 Antikörper), and Pr-Set7 (zeige SETD8 Antikörper) were not affected by ubH2A.

  6. WHSC1 links transcription elongation to HIRA (zeige HIRA Antikörper)-mediated histone H3.3 (zeige H3F3A Antikörper) deposition.

  7. H3K36me3-specific histone methyltransferase WHSC1 (also NSD2 or MMSET) functions in transcriptional regulation together with developmental transcription factors whose defects overlap with the human disease Wolf-Hirschhorn syndrome

WHSC1 Antigen-Profil

Protein Überblick

This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4\;14)(p16.3\;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences.

Genbezeichner und Symbole assoziert mit WHSC1

  • nuclear receptor binding SET domain protein 2 (NSD2) Antikörper
  • nuclear receptor binding SET domain protein 2 (nsd2) Antikörper
  • Wolf-Hirschhorn syndrome candidate 1 (WHSC1) Antikörper
  • nuclear receptor binding SET domain protein 2 (Nsd2) Antikörper
  • 5830445G22Rik Antikörper
  • 9430010A17Rik Antikörper
  • AW555663 Antikörper
  • C130020C13Rik Antikörper
  • D030027O06Rik Antikörper
  • D930023B08Rik Antikörper
  • fc12c04 Antikörper
  • mKIAA1090 Antikörper
  • MMSET Antikörper
  • NSD2 Antikörper
  • REIIBP Antikörper
  • RGD1565590 Antikörper
  • si:rp71-77d7.2 Antikörper
  • TRX5 Antikörper
  • WHS Antikörper
  • WHSC1 Antikörper
  • Whsc1l Antikörper
  • wu:fc12c04 Antikörper
  • wu:fi20c01 Antikörper

Bezeichner auf Proteinebene für WHSC1

Wolf-Hirschhorn syndrome candidate 1 protein , Wolf-Hirschhorn syndrome candidate 1 , probable histone-lysine N-methyltransferase NSD2 , IL5 promoter REII region-binding protein , histone-lysine N-methyltransferase NSD2 , multiple myeloma SET domain containing protein type III , nuclear SET domain-containing protein 2 , trithorax/ash1-related protein 5 , multiple myeloma SET domain-containing protein , wolf-Hirschhorn syndrome candidate 1 protein homolog

461070 Pan troglodytes
540769 Bos taurus
100000709 Danio rerio
100051090 Equus caballus
100125213 Xenopus (Silurana) tropicalis
479077 Canis lupus familiaris
7468 Homo sapiens
422897 Gallus gallus
680537 Rattus norvegicus
107823 Mus musculus
Ausgewählte Anbieter für anti-WHSC1 (WHSC1) Antikörper
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