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Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Zusätzlich bieten wir Ihnen WTIP Antikörper (23) und WTIP Kits (5) und viele weitere Produktgruppen zu diesem Protein an.
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WTIP interacts with BRCA2 (zeige BRCA2 Proteine) and might be responsible for BRCA2 (zeige BRCA2 Proteine) centrosome localization in cervical cancer cell.
Nck1 (zeige NCK1 Proteine) and Nck2 (zeige NCK2 Proteine) Interact with WTIP. Nck1 (zeige NCK1 Proteine)/2 integrates nephrin (zeige NPHS1 Proteine) with the Hippo kinase cascade through association with the adaptor protein WTIP.
WTIP interacts with ASXL2 and blocks ASXL2-mediated activation of retinoic acid signaling.
Wtip regulates the stable formation of cell adhesions to both extracellular matrix and neighboring cells and suggest that Wtip is necessary for normal glomerular filtration barrier function
Report role of WTIP in regulating podocyte phenotype in chronic kidney disease.
Full-length Ror2 (zeige ROR2 Proteine) recruits Wtip to the cell membrane, a mutant involved in human disease fails to do so. Both genes and proteins show overlapping expression in the mouse embryo.
WTIP is a member of the Ajuba family of LIM-domain containing proteins. Ajuba LIM proteins co-repress E-cadherin expression through interaction with the SNAG domain of Snail/Slug and promote epithelial to mesenchymal differentiation in a Xenopus model.
Stress signaling pathways initiate WTIP nuclear translocation, and the concomitant loss of WTIP from cell contacts changes podocyte morphology and dynamic actin assembly, suggesting a mechanism that transmits changes in podocyte morphology to the nucleus.
WTIP monitors slit diaphragm protein assembly as part of a multiple protein complex, linking this specialized adhesion junction to the actin cytoskeleton, and shuttles into the nucleus after podocyte injury
implicate Asxl1 (zeige ASXL1 Proteine) in the maintenance of podocyte structure via its association with Wtip and in the regulation of WT1 (zeige WT1 Proteine) signaling during early kidney development
ASXL2 and WTIP are expressed in mouse embryonic epicardial cells. ASXL2 and WTIP participate in regulation of retinoic acid signaling during heart development.
Dendrin is dispensable for the function of the normal glomerular filtration barrier, and it interacts with Wtip and Gadd45a (zeige GADD45A Proteine).
Podocyte injury induces nuclear translocation of WTIP via microtubule-dependent transport
Full-length Ror2 (zeige ROR2 Proteine) recruits Wtip to the cell membrane, a mutant involved in human disease fails to do so.
Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. May monitor slit diaphragm protein assembly, a specialized adherens junction characteristic of podocytes. In case of podocyte injury, it shuttles into the nucleus and acts as a transcription regulator that represses WT1- dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype.
, Wilms tumor protein 1-interacting protein
, Wilms tumor protein 1-interacting protein homolog
, WT1-interacting protein homolog
, Wilms tumor 1 interacting protein