WNK Lysine Deficient Protein Kinase 4 Proteine (WNK4)

WNK4 encodes a member of the WNK family of serine-threonine protein kinases.

alle Proteine anzeigen Gen GeneID UniProt
Human WNK4 WNK4 65266 Q96J92
Maus WNK4 WNK4 69847 Q80UE6
Ratte WNK4 WNK4 287715 Q7TPK6
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$12,127.90
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
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Baculovirus infected Insect Cells Maus GST tag   5 μg Anmelden zum Anzeigen 10 bis 12 Tage
$352.75
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Insektenzellen Human GST tag   5 μg Anmelden zum Anzeigen 11 bis 12 Tage
$613.33
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Insektenzellen Maus GST tag   10 μg Anmelden zum Anzeigen 3 bis 4 Tage
$310.00
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Weitere Proteine zu WNK Lysine Deficient Protein Kinase 4 (WNK4) Interaktionspartnern

Human WNK Lysine Deficient Protein Kinase 4 (WNK4) Interaktionspartner

  1. 5 WNK4 sites (S47, S64, S1169, S1180, S1196) are phosphorylated downstream of AngII signaling in cultured cells and in vitro by PKC (zeige PRRT2 Proteine) and PKA. Phosphorylation at S64 and S1196 promoted phosphorylation of the WNK4 kinase T-loop at S332 (required for kinase activation) and increased phosphorylation of SPAK (zeige STK39 Proteine). Volume depletion induced phosphorylation of these sites in vivo, predominantly in the distal convoluted tubule.

  2. Modulation of WNK4 activity by [Cl]i can account for its dual role on the NCC (zeige SLC12A3 Proteine), and this has important physiological implications regarding the regulation of extracellular potassium concentration.

  3. This study provides substantial new insights into the role of phosphorylation of KLHL3 (zeige KLHL3 Proteine) in regulating the interaction with WNK4

  4. The distribution of allele frequency and genotype of WNK4 gene Ala589Ser polymorphism showed significant differences between essential hypertension subjects, with or without type 2 diabetes mellitus, and normotensive subjects.

  5. Data indicate that WNK lysine deficient protein kinase 4 protein (WNK4) was degraded not only by proteasomes but also by atypical protein kinase C scaffold protein p62 (p62)-kelch-like 3 protein (KLHL3)-mediated selective autophagy.

  6. this meta-analysis suggested that WNK4 G1155942T and C6749T gene polymorphisms may contribute to the susceptibility and development of hypertension.

  7. Akt (zeige AKT1 Proteine) and PKA phosphorylated KLHL3 (zeige KLHL3 Proteine) at S433, and phosphorylation of KLHL3 (zeige KLHL3 Proteine) by PKA inhibited WNK4 degradation.

  8. WNK4 is a substrate of SFKs and the association of c-Src (zeige SRC Proteine) and PTP-1D (zeige PTPN11 Proteine) with WNK4 at Tyr (zeige TYR Proteine)(1092) and Tyr (zeige TYR Proteine)(1143) plays an important role in modulating the inhibitory effect of WNK4 on ROMK (zeige KCNJ1 Proteine)

  9. WNK4 inhibits SNARE (zeige NAPA Proteine) formation of syntaxin 13 (zeige STX12 Proteine) with VAMP2 (zeige VAMP2 Proteine).

  10. Regulation of WNK4 by CUL3 (zeige CUL3 Proteine) and its relationship to blood pressure regulation and electrolyte homeostasis. [Review]

Mouse (Murine) WNK Lysine Deficient Protein Kinase 4 (WNK4) Interaktionspartner

  1. WNK4 protein affected the DNA-binding ability of C/EBPbeta (zeige CEBPB Proteine) and thereby reduced PPARgamma (zeige PPARG Proteine) expression. In the WNK4(-/-) mice, PPARgamma (zeige PPARG Proteine) and C/EBPalpha (zeige CEBPA Proteine) expression were decreased in adipose tissues, and the mice exhibited partial resistance to high-fat diet-induced adiposity.

  2. However, phosphorylation of SPAK (zeige STK39 Proteine) and NCC (zeige SLC12A3 Proteine) at distal convoluted tubules were almost completely absent even in WNK4(-/-)KLHL3 (zeige KLHL3 Proteine)(R528H/R528H) mice. In conclusion, increased WNK1 (zeige WNK1 Proteine) was unable to compensate for WNK4 deficiency and phosphorylate the NCC (zeige SLC12A3 Proteine), indicating that WNK4 is indispensable for the onset of PHAII.

  3. ENaC (zeige SCNN1A Proteine) and ROMK (zeige KCNJ1 Proteine) channel activity in kidney tubules are inhibited in TgWnk4(pseudoaldosteronism type II) mice. Wnk4(PHAII)-induced inhibition of ENaC (zeige SCNN1A Proteine) and ROMK (zeige KCNJ1 Proteine) may contribute to the suppression of K(+) secretion in the tubules.

  4. Accordingly, medullary WNK4 protein levels were significantly increased in the kidneys of KLHL2 (zeige KLHL2 Proteine)(-/-) mice. KLHL2 (zeige KLHL2 Proteine) is indeed a physiological regulator of WNK4 in vivo; however, its function might be different from that of KLHL3 (zeige KLHL3 Proteine) because KLHL2 (zeige KLHL2 Proteine) mainly localized in medulla.

  5. The results indicate that quite modest changes in dietary K intake affect plasma [K] and thiazide-sensitive NaCl cotransporter activity. These effects are mediated largely by WNK4, as this kinase exhibits unique Cl-sensitive properties.

  6. the increased NCC (zeige SLC12A3 Proteine) expression and activation is present in CMA which is highly associated with the enhanced WNK4-SPAK (zeige STK39 Proteine) signal pathway using WNK4-/- and SPAK (zeige STK39 Proteine)-/- mice.

  7. increased protein expression levels of WNK1 (zeige WNK1 Proteine) and WNK4 kinases cause PHAII by KLHL3 (zeige KLHL3 Proteine) R528H mutation due to impaired KLHL3 (zeige KLHL3 Proteine)-Cullin3-mediated ubiquitination.

  8. KLHL3 (zeige KLHL3 Proteine) is phosphorylated at serine 433 in the Kelch domain (a site frequently mutated in hypertension with hyperkalemia) by protein kinase C in cultured cells and that this phosphorylation prevents WNK4 binding and degradation.

  9. WNK4 is the major positive regulator of NCC (zeige SLC12A3 Proteine) in the kidneys.

  10. WNK1 (zeige WNK1 Proteine) stimulates the activity of the Na-Cl cotransporter (zeige SLC12A3 Proteine) via SPAK (zeige STK39 Proteine), an effect antagonized by WNK4.

WNK4 Protein Überblick

Protein Überblick

This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.

Genbezeichner und Symbole assoziert mit WNK4

  • WNK lysine deficient protein kinase 4 (WNK4)
  • WNK lysine deficient protein kinase 4 (Wnk4)
  • 2010002J11Rik Protein
  • Ac2-059 Protein
  • Pha2b Protein
  • Prkwnk4 Protein
  • WNK4 Protein

Bezeichner auf Proteinebene für WNK4

WNK lysine deficient protein kinase 4 , protein kinase lysine-deficient 4 , protein kinase with no lysine 4 , serine/threonine-protein kinase WNK4 , protein kinase, lysine deficient 4 , WNK4 Ser/Thr kinase , protein kinase, lysine-deficient 4

GENE ID SPEZIES
454699 Pan troglodytes
490959 Canis lupus familiaris
100139742 Bos taurus
100617641 Monodelphis domestica
65266 Homo sapiens
69847 Mus musculus
287715 Rattus norvegicus
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