Vpx Protein Proteine (VPX)

Plays a role in nuclear translocation of the viral pre- integration complex (PIC), thus is required for the virus to infect non-dividing cells. Zusätzlich bieten wir Ihnen Vpx Protein Antikörper (12) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
VPX 1490006 Q02842;
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Showing 2 out of 3 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) REACT_Human Immunodeficiency Virus His tag 100 μg Anmelden zum Anzeigen 11 Days
Escherichia coli (E. coli) REACT_Simian Immunodeficiency Virus His-SUMO Tag 100 μg Anmelden zum Anzeigen 11 Days

VPX Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Simian Immunodeficiency Virus (SIV)

Human Immunodeficiency Virus (HIV)

Weitere Proteine zu Vpx Protein (VPX) Interaktionspartnern

Simian Immunodeficiency Virus (SIV) Vpx Protein (VPX) Interaktionspartner

  1. Data suggest that a critical role of vpx in vivo/in vitro is to promote degradation of SAMHD1 (SAM domain/HD domain protein 1) in memory CD4+ T-lymphocytes, thereby generating high levels of plasma viremia and induction of immunodeficiency.

  2. Vpr and Vpx share a highly similar DCAF1-binding motif, they interact with a different set of residues in DCAF1.

  3. SIV vpx is essential for macrophage infection but not for development of simian AIDS.

  4. Inhibition of deoxynucleotide hydrolysis by promoting SAMHD1 degradation is not the only mechanism by which Vpx rescues HIV-1 in mature monocyte-derived dendritic cells from the antiviral state.

  5. direct down-modulation of Vpx catalytic activity, mediated by the same binding event that leads to SAMHD1 recruitment to the E3 ubiquitin ligase for proteasome-dependent degradation

  6. The authors demonstrate that the Wx4Phix2Phix3APhixH motif in SIVmac Vpx is required for both the Vpx-DCAF1 interaction and/or Vpx-mediated degradation of SAMHD1.

  7. However, all the vpx mutant viruses were defective for replication in both human and pigtail monocyte-derived macrophages.

  8. Vpx induces proteasomal degradation of SAMHD1

  9. Vpx relieves the inhibition of lentivirus infection in macrophages by loading SAMHD1 onto the CRL4(DCAF1) E3 ubiquitin ligase, leading to highly efficient proteasome-dependent degradation of the protein

  10. This review describes the main functions ascribed to Vpr and Vpx in the context of both viral replication and modulation of host cell biology

  11. A single-point mutation in Vpx (H82A) abrogated binding to APOBEC3A and single-round infection of monocytes by HIV-1.

  12. Vpx is essential to overcome a block of early infection steps in primary monocytes

  13. host cell MAPK signal transduction pathway regulates an early step in SIV infection

  14. MacrophageS harbor a potent antiviral restriction; primate lentiviruses have evolved Vpx to counteract this restriction.

  15. when transferred in the context of a replication-competent viral clone, Vpx was required for replication in dendritic cells

Vpx Protein (VPX) Protein Überblick

Protein Überblick

Plays a role in nuclear translocation of the viral pre- integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription (By similarity). {ECO:0000250}.

Genbezeichner und Symbole assoziert mit Vpx Protein Proteine (VPX)

  • vpx protein (vpx)

Bezeichner auf Proteinebene für Vpx Protein Proteine (VPX)

Viral protein X , X ORF protein

1490006 Simian immunodeficiency virus
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