anti-Vitamin K-dependent protein C (PROC) Antikörper

PROC encodes a vitamin K-dependent plasma glycoprotein. Zusätzlich bieten wir Ihnen PROC Kits (66) und PROC Proteine (36) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
PROC 25268 P31394
PROC 19123 P33587
PROC 5624 P04070
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Top anti-PROC Antikörper auf antikoerper-online.de

Showing 10 out of 217 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IHC (p), WB Anti-Protein C antibody, Western blotting Lane 1: JURKAT Cell Lysate Lane 2: CEM Cell Lysate Lane 3: SMMC Cell Lysate Lane 4: HELA Cell Lysate Anti-Protein C antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$280.00
Details
Pferd Kaninchen Unkonjugiert IHC, WB WB Suggested Anti-PROC Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  MCF7 cell lysate Host:  Rabbit  Target Name:  PROC  Sample Type:  Human Adult Placenta  Antibody Dilution:  1.0ug/ml 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert WB WB Suggested Anti-PRH2 Antibody Titration: 1.0 ug/ml Positive Control: Fetal Heart 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$319.00
Details
Ziege Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-PROC Antibody Titration:  2.5ug/ml  Positive Control:  Transfected 293T 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$229.00
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of Protein C expression in HeLa (A), Raw264.7 (B), H9C2 (C) whole cell lysates. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Kaninchen Unkonjugiert WB WB Image Sample (30 ug of whole cell lysate) A: Molt-4 , 10% SDS PAGE antibody diluted at 1:3000 100 μL Anmelden zum Anzeigen 3 bis 4 Tage
$466.18
Details
Human Kaninchen Unkonjugiert ELISA, IHC (p), WB Immunohistochemistry (IHC) analysis of paraffin-embedded Human Colon, antibody was diluted at 1:100. 100 μL Anmelden zum Anzeigen Verfügbar
$181.73
Details
Human Ziege Unkonjugiert ELISA, IEP, IHC, IHC (p) Vessels, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Liver, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) 250 μg Anmelden zum Anzeigen 11 bis 14 Tage
$727.83
Details
Fledermaus Kaninchen Unkonjugiert WB 100 μg Anmelden zum Anzeigen 11 bis 14 Tage
$493.17
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Am meisten referenzierte anti-PROC Antikörper

  1. Human Polyclonal PROC Primary Antibody für IHC (p), WB - ABIN3044486 : Liu, An, Liu, Li, Tang, Chen: Mouse lung slices: An ex vivo model for the evaluation of antiviral and anti-inflammatory agents against influenza viruses. in Antiviral research 2015 (PubMed)
    Show all 10 Pubmed References

  2. Cow (Bovine) Polyclonal PROC Primary Antibody für EIA, RIA - ABIN613777 : Satou, Nishi, Hishinuma, Hosoda, Kangawa, Sugimoto: Identification of activated protein C as a ghrelin endopeptidase in bovine plasma. in The Journal of endocrinology 2014 (PubMed)

Weitere Antikörper gegen PROC Interaktionspartner

Mouse (Murine) Vitamin K-dependent protein C (PROC) Interaktionspartner

  1. These results support the concept that APC-induced, PAR1-dependent biased signaling following R46 cleavage is central to the in vivo benefits of APC.

  2. Data show that activated protein C signals via protease activated receptors PAR2/PAR3 to expand Treg cells, mitigating the disease in mice.

  3. insulin and aPC converge on a common spliced-X-box binding protein-1 (sXBP1) signaling pathway to maintain endoplasmic reticulum (ER) homeostasis.

  4. loss of the convertase furin or PC5/6 in hepatocytes results in a approximately 30% decrease in APC levels, with no significant contribution from PACE4. We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin activation.

  5. APC modifies pulmonary fibrosis by limiting thrombin-dependent macrophage recruitment.

  6. Small interfering RNA-mediated silencing of protein C in apolipoprotein E-deficient mice creates a condition that allows the occurrence of spontaneous atherothrombosis.

  7. These findings reveal a novel biological function and mechanism of the protein C pathway in which protein S and the aPC-cleaved form of fV are cofactors for anti-inflammatory cell signaling by aPC in the context of endotoxemia and infection

  8. activated PC-EPCR-PAR1 signaling promotes hematopoietic stem cell retention in bone marrow.

  9. impaired EPCR/protein C-binding interactions not only result in procoagulant and proinflammatory effects, but also impact hematopoiesis

  10. SOD prevents thrombomodulin methionine oxidation, promotes protein C activation, and protects against arterial and venous thrombosis in mice.

  11. sPLA2-V plays a thrombogenic role by impairing the ability of EPCR to promote protein C activation.

  12. Data identify anticoagulant activated protein C as a "metaplastic molecule", capable of shifting the threshold of LTP towards further potentiation

  13. Histones regulate activated protein C formation in a manner similar to PF4 and suggest heparinoids may be benificial in sepsis.

  14. EPCR and APC play a limited role in the host response during pulmonary tuberculosis.

  15. Inhibition of the anticoagulant function of activated protein C does not interfere with its protective role during Gram-negative pneumosepsis, suggesting a more prominent role for cytoprotective effects of APC .

  16. RNA interference of Serpinc1 and/or Proc allows for evaluation of the function of these genes in vivo and provides a novel, controlled mouse model for spontaneous venous thrombosis.

  17. Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc.

  18. Polyphosphate can elicit potent pro-inflammatory responses through the activation of NF-kappaB, which are counteracted by activated protein C.

  19. The aPC mechanism of action is complex, involving induction of Treg differentiation, inhibition of inflammation, and possibly direct cyto-protective effects on beta cells.

  20. We conclude that activated protein C generation and function can be modulated by changes in phospholipid occupancy of its endothelial cell receptor.

Human Vitamin K-dependent protein C (PROC) Interaktionspartner

  1. The frequency of SERPINC1, PROC, and PROS1 mutations and their thromboembolic manifestations was characterized in patients with AT, PC, or PS deficiencies, inhabiting southern Poland.

  2. The fusion protein recapitulates the functional and structural properties of the thrombin-thrombomodulin complex, prolongs the clotting time by generating pharmacological quantities of activated protein C and effectively diagnoses protein C deficiency in human plasma.

  3. Polymorphisms of F2, PROC, PROZ, and F13A1 Genes are Associated With Recurrent Spontaneous Abortion in Chinese Han Women.

  4. Laboratory tests and direct sequencing of PROC and SERPINC1 were conducted for the patient and his family members. Coagulation tests revealed that the patient presented type I antithrombin deficiency combined with decreased protein C activity resulting from a small insertion mutation c.848_849insGATGT in SERPINC1 and a short deletion variant c.572_574delAGA in PROC.

  5. Patients with rheumatoid arthritis, polymyositis, systemic lupus erythematosus and ankylosing spondylitis showed higher serum levels of than healthy control individuals.

  6. Using protein C-factor VII chimera demonstrate that APC light chain amino acid residues outside the EPCR-binding site enable cytoprotective PAR1 signaling.

  7. We recently identified a venous thrombosis patient whose plasma level of protein C antigen is normal, but its anticoagulant activity is only 34 % of the normal level. Genetic analysis revealed that the proband and her younger brother carry a novel heterozygous mutation c.346G>A, p.Gly74Ser (G74S) in PROC.

  8. Developed functional protein S assays that measure both the activated protein C- and TFPI-cofactor activities of protein S in plasma, which are hardly if at all affected by the FV Leiden mutation.

  9. Protein C seems inversely associated with mortality in patients with advanced prostate, lung and pancreatic cancer. Further research should validate protein C as a biomarker for mortality, and explore the effects of protein C on progression of cancer.

  10. Genetically higher protein C was associated with a lower risk of ischaemic heart disease.

  11. EPCR occupancy recruits G-protein coupled receptor kinase 5, thereby inducing beta-arrestin-2 biased PAR1 signaling by both APC and thrombin. In

  12. A novel mutation of A309V in PROC was determined in a family of two patients with late onset protein C deficiency

  13. loss of the convertase furin or PC5/6 in hepatocytes results in a approximately 30% decrease in APC levels, with no significant contribution from PACE4. We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin activation.

  14. Both probands had hereditary protein C deficiencies, for which their parents were all carriers.

  15. Variants influencing circulating protein C levels in the CELSR2-PSRC1-SORT1 region may indicate a novel genetic link between lipoprotein metabolism and hemostasis.

  16. These findings suggest that the anti-inflammatory function of APC at therapeutic concentrations may include the inhibition of NETosis in an EPCR-, PAR3-, and Mac-1-dependent manner, providing additional mechanistic insight into the diverse functions of neutrophils and APC in disease states including sepsis.

  17. Collectively, these data depict a pivotal role for AMPK signaling in inhibiting ER stress responses via the activation of APC during MGO-induced cardiomyocyte apoptosis. Thus, APC may be a potential novel therapeutic target for the management of diabetic cardiovascular complications such as diabetic cardiomyopathy.

  18. An activation-resistant homozygous protein C R229W mutation was linked to perinatal intracranial bleeding and delayed onset of thrombosis.

  19. Structural and functional studies of novel heterozygous mutations in the PROC gene confirmed that the mutations were pathogenetic in two Chinese families with types I and II protein C deficiency.

  20. The odds ratio of developing idiopathic fatal pulmonary embolism as a variant carrier for PROC is 85.6 (95% CI, 13.0-448.9; P = 2.0 x 10- 5.

Cow (Bovine) Vitamin K-dependent protein C (PROC) Interaktionspartner

  1. Activated protein c is a ghrelin endopeptidase.

  2. Activated protein C(APC) combined with protein S(PS) had significant antithrombotic effect. APC combined with PS prolonged clotting time. Dependence on APC-cofactor activity of PS for expression of anticoagulant activity by APC.

PROC Antigen-Profil

Protein Überblick

This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.

Genbezeichner und Symbole assoziert mit PROC

  • protein C (inactivator of coagulation factors Va and VIIIa), a (proca) Antikörper
  • protein C, inactivator of coagulation factors Va and VIIIa (PROC) Antikörper
  • protein C (inactivator of coagulation factors Va and VIIIa) (PROC) Antikörper
  • protein C, inactivator of coagulation factors Va and VIIIa S homeolog (proc.S) Antikörper
  • protein C, inactivator of coagulation factors Va and VIIIa (proc) Antikörper
  • vitamin K-dependent protein C (CpipJ_CPIJ000393) Antikörper
  • vitamin K-dependent protein C (CpipJ_CPIJ002754) Antikörper
  • vitamin K-dependent protein C (CpipJ_CPIJ003717) Antikörper
  • vitamin K-dependent protein C (CpipJ_CPIJ003718) Antikörper
  • vitamin K-dependent protein C (CpipJ_CPIJ014440) Antikörper
  • vitamin K-dependent protein C (CpipJ_CPIJ018032) Antikörper
  • vitamin K-dependent protein C (CpipJ_CPIJ018737) Antikörper
  • protein C, inactivator of coagulation factors Va and VIIIa (Proc) Antikörper
  • protein C (Proc) Antikörper
  • APC Antikörper
  • MGC64425 Antikörper
  • PC Antikörper
  • PROC Antikörper
  • PROC1 Antikörper
  • si:ch1073-188c16.3 Antikörper
  • THPH3 Antikörper
  • THPH4 Antikörper
  • zgc:63987 Antikörper

Bezeichner auf Proteinebene für PROC

protein C , procl , anticoagulant protein C , vitamin K-dependent protein C , protein C (inactivator of coagulation factors Va and VIIIa) , vitamin K-dependent protein C-like , autoprothrombin IIA , blood coagulation factor XIV , inactivator of coagulation factors Va, VIII , catalytic region , protein C (precursor of vitamin K-dependent serine protease)

GENE ID SPEZIES
393327 Danio rerio
395085 Gallus gallus
459593 Pan troglodytes
100302329 Ovis aries
380116 Xenopus laevis
548476 Xenopus (Silurana) tropicalis
100231143 Taeniopygia guttata
100448857 Pongo abelii
6031231 Culex quinquefasciatus
6033948 Culex quinquefasciatus
6035053 Culex quinquefasciatus
6035054 Culex quinquefasciatus
6047546 Culex quinquefasciatus
6052150 Culex quinquefasciatus
6052641 Culex quinquefasciatus
25268 Rattus norvegicus
19123 Mus musculus
5624 Homo sapiens
281428 Bos taurus
101096161 Felis catus
476104 Canis lupus familiaris
100051306 Equus caballus
396954 Sus scrofa
100009223 Oryctolagus cuniculus
699077 Macaca mulatta
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