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VAX2 encodes a homeobox protein and is almost exclusively expressed in the ventral portion of the retina during development. Zusätzlich bieten wir Ihnen VAX2 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.
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This study raises the interesting possibility for evaluating VAX2 as a candidate gene for cone dystrophy.
Although inappropriate promoter methylation was not invariantly associated with reduced transcript expression, a significant association was apparent for the ARHGEF4, PON3, STAT5a, and VAX2 gene transcripts (P<0.05). Herein, we present the first genome-wide DNA methylation analysis in a unique HG-NMIBC cohort, showing extensive and discrete methylation changes relative to normal bladder and low-intermediate-grade tumor
A susceptibility locus was identified with lead single nucleotide polymorphism rs3771395 on chromosome 2p13.3 (meta-analysis, P = 1.97 x 10(-7)) in the VAX2 gene for astigmatism.
vax1 and vax2 are expressed in overlapping domains encompassing the ventral retina, optic stalks and preoptic area; Hh signals act downstream of the Nodal pathway to promote Vax gene expression.
Vax1 and Vax2 genes counteract Mitf-induced respecification of the retinal pigment epithelium.
Vax2 is both necessary and sufficient for the control of intraretinal retinoic acid metabolism, which in turn contributes to the appropriate expression of cone opsins in the vertebrate eye.
This gene encodes a homeobox protein and is almost exclusively expressed in the ventral portion of the retina during development. In mouse studies, this gene was found to be required for the correct formation of the optic fissure and other aspects of retinal development.
ventral anterior homeobox 2
, ventral anterior homeobox 2b
, ventral anterior homeobox 3
, ventral anterior homeobox containing gene 2
, ventral retina homeodomain protein