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VRK1 encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases.
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vrk-1 has a role in early uterine development in Caenorhabditis elegans
By coordinating VRK-1- and PP2A-mediated signaling on BAF, Lem4 and LEM-4L (Y55F3BR.8) controls postmitotic nuclear envelope formation in a function conserved from worms to humans.
Genome-wide analysis of germ cell proliferation in C. elegans identifies vrk-1 as a key regulator of cep-1/p53 (zeige TP53 ELISA Kits).
Data show that expression of the fibroblast growth factor-like protein EGL-17 and its receptor EGL-15 is reduced in vrk-1 mutants, suggesting that VRK-1 might act at least partially through activation of FGF signaling.
this study not only provides a resource for investigating the unidentified functions of VRK1/VRK3, but also an insight into the regulatory roles of VRK1/VRK3 in biological processes.
Block the activation of the VRK1 promoter by Sox2 (zeige SOX2 ELISA Kits).
VRK1 and BANF1 yielded AUCs of 0.790 and 0.735, respectively.
VRK1 AND VRK2 (zeige VRK2 ELISA Kits) expression are predictive of tumor response to neoadjuvant chemoradiation therapy in rectal adenocarcinoma.
VRK1 was lowly expressed in adherent MM cells and highly expressed in suspended cells. In addition, VRK1 was positively correlated with the proliferation of MM cells by regulating the expression of cell cycle-related protein, such as cyclinD1, CDK2 (zeige CDK2 ELISA Kits) and p27(kip1 (zeige CDKN1B ELISA Kits)).
we conclude that VRK1 may be a candidate prognostic biomarker as well as a potential therapeutical target of hepatocellular carcinoma
VRK1 may act as a tumor promoter by controlling the level of cell cycle regulators associated with G1/S transition and could potentially serve as a therapeutic target and/or prognostic biomarker for HCC.
VRK1 is a novel regulator of CBs dynamics and stability in cell cycle by protecting coilin from ubiquitination and degradation in the proteasome, and propose a model of CB dynamics.
VRK1 regulation of NBS1 (zeige NBN ELISA Kits) contributes to the stability of the repair complex and permits the sequential steps in DNA damage response.
VRK1 is a novel chromatin component that reacts to its alterations and participates very early in DNA damage response, functioning by itself or in cooperation with Ataxia Telangiectasia Mutated (zeige ATM ELISA Kits) Proteins.
VRK1 self-represses its activity to phosphorylate PXR (zeige NR1I2 ELISA Kits) through cyclin-dependent kinase 2 (CDK2 (zeige CDK2 ELISA Kits)) in high glucose conditions, resulting in the repression of the PCK1 (zeige PCK1 ELISA Kits) gene. This PXR (zeige NR1I2 ELISA Kits) phosphorylation was also observed in fasting mouse livers. Thus, the VRK1-CDK2 (zeige CDK2 ELISA Kits)-PXR (zeige NR1I2 ELISA Kits)-PP2Calpha (zeige PPM1A ELISA Kits)-SGK2 (zeige SGK2 ELISA Kits) pathway can be a novel physiological cell signaling that regulates gluconeogenesis in response to glucose.
VRK1 deficiency in human and mouse leads to downregulation of amyloid-beta precursor protein (APP (zeige APP ELISA Kits)). APP (zeige APP ELISA Kits) overexpression rescues the phenotype caused by Vrk1 knockdown, suggesting that VRK1 affects neuronal migration through an APP (zeige APP ELISA Kits)-dependent mechanism.
Data suggest that VRK1 is required for both follicle development and oocyte growth in mammalian female reproduction system.
Protein kinase (zeige CDK7 ELISA Kits) Cdelta regulates phosphorylation and down-regulation of Vaccinia-related kinase 1 (VRK1), thereby contributing to cell cycle arrest and apoptotic cell death in a p53 (zeige TP53 ELISA Kits)-dependent manner.
reduction of VRK1 activity causes a delay in meiotic progression during oogenesis
VRK1 is required for the proliferation and differentiation of undifferentiated spermatogonia, which are essential for spermatogenic cell maintenance
Depletion of VRK1 leads to progressive male infertility as a result of a cessation of spermatogonial proliferation.
These findings collectively support a role of VRK1 as a novel mitotic histone H3 (zeige HIST3H3 ELISA Kits) kinase in mammals.
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.
vaccinia related kinase 1
, serine/threonine-protein kinase VRK1
, serine/threonine-protein kinase VRK1-like
, vaccinia virus B1R-related kinase 1
, vaccinia-related kinase 1
, serine/threonine-protein kinase 51PK