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The protein encoded by MAFB is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. Zusätzlich bieten wir Ihnen MAFB Antikörper (51) und viele weitere Produktgruppen zu diesem Protein an.
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These results suggest that MAFB and MAFF (zeige MAFF Proteine) play critical roles in the antitumor effects of retinoids by regulating the expression of retinoid target genes such as TFPI2 (zeige TFPI2 Proteine) and can be promising for developing therapies to combat HCC (zeige FAM126A Proteine) invasion.
MAFB enhanced leukemogenesis by the naturally occurring Notch1 (zeige NOTCH1 Proteine) mutants, decreased disease latency, and increased disease penetrance.
USP5 (zeige USP5 Proteine) regulates c-Maf (zeige MAF Proteine) stability and multiple myeloma cell survival.
Data suggest that SUMOylated MAFB promotes colorectal cancer tumorigenesis through cell cycle regulation.
these results demonstrate that MAFB critically determines the acquisition of the anti-inflammatory transcriptional and functional profiles of human macrophages
The present study demonstrated that miR (zeige MLXIP Proteine)-152 was downregulated in NPC (zeige NPC1 Proteine) tissues and cell lines. In addition, miR (zeige MLXIP Proteine)-152 expression and MAFB knockdown inhibited cell proliferation, migration and invasion, and miR (zeige MLXIP Proteine)-152 suppressed the expression of MAFB at the mRNA and protein levels.
Epidermal differentiation gene regulatory networks are controlled by MAF (zeige MAF Proteine) and MAFB.
Loss of MAFB Function Causes Duane Syndrome, Aberrant Extraocular Muscle Innervation, and Inner-Ear Defects.
Results indicate a hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) regulatory pathway involving MafB transcription factor and cyclin D1 (zeige CCND1 Proteine), the dysfunction of which drives proliferative character in HCC (zeige FAM126A Proteine).
DNMT3A (zeige DNMT3A Proteine) R882 mutation is associated with elevated expression of MAFB and M4/M5 immunophenotype of acute myeloid leukemia (zeige BCL11A Proteine) blasts.
Vegfc (zeige VEGFC Proteine) signaling increases mafba expression to control downstream transcription
The expression of the first protein in the classical complement pathway C1q is important for mediating efferocytosis and is reduced in Mafb-deficient macrophages.
present findings indicate that MafB enhances efferocytosis by regulating Axl (zeige AXL Proteine) expression in RAW264.7 macrophages
Therefore, MafB promotes differentiation in postmitotic keratinocytes and simultaneously has potential to promote growth when ectopically expressed in undifferentiated basal keratinocytes.
MAFB localized in Leydig and Sertoli cells in testes at E18.5 while it localized in Leydig cells, Sertoli cells, and pachytene spermatocytes in adult testes. Examination revealed that MAFB-deficient testes developed normally by E18.5, and spermatogenesis was not disrupted in adult mice. MAFB MAFB might be critical for phagocytosis activity of Sertoli cells.
MafB controls endothelial sprouting in vitro and in vivo in postnatal retinal angiogenesis.
Macrophage-specific inhibition of MafB may destabilize atherosclerotic plaques in advanced lesions
a protective role of oxLDL-associated LPS (zeige TLR4 Proteine) on beta-cell function during hyperlipidemia by inducing miR (zeige MLXIP Proteine)-155-5p, which prevents the upregulation of MafB and beta-to-alpha-cell reprogramming.
Increased mafB at the common myeloid progenitor stage steers their lineage away from the megakaryocyte erythrocyte progenitor production and drives the terminal fate of these progenitors to form macrophages vs. dendritic cells, causing anemia, monocytosis, and dendritic cell loss. It is a transcriptional activator of M-CSFR (zeige CSF1R Proteine) and a repressor of transferrin (zeige Tf Proteine) receptors, promoting macrophages and plasmacytoid dendritic cells.
An elevation of MSR1 (zeige MSR1 Proteine) levels in infiltrating myeloid cells observed 3 d after experimental stroke was dependent on the transcription factor Mafb. Mafb deficiency in infiltrating myeloid cells caused impaired clearance of DAMPs, more severe inflammation, and exacerbated neuronal injury in a murine model of ischemic stroke.
a Mafb-driven Cre strain was generated to determine whether any dendritic cells (DCs) identified by Zbtb46 (zeige ZNF340 Proteine)-green fluorescent protein expression originate from a Mafb-expressing population.
The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. The encoded nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells. This gene contains no introns.
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
, v-maf musculoaponeurotic fibrosarcoma oncogene protein B
, v-maf musculoaponeurotic fibrosarcoma oncogene homolog B
, Transcription factor MafB
, bzip transcription factor mafB
, transcription factor MafB
, Kreisler maf-related leucine zipper homolog
, MAFB/Kreisler basic region/leucine zipper transcription factor
, Kreisler maf-related leucine zipper homolog (b-maf)
, transcription factor Maf-1
, v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B
, transcription factor Val
, Kreisler (maf-related) leucine zipper protein
, V-maf musculoaponeurotic fibrosarcoma oncogene homolog B
, segmentation protein Kr