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The protein encoded by MAF is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Zusätzlich bieten wir Ihnen V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (Avian) Antikörper (142) und V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (Avian) Kits (27) und viele weitere Produktgruppen zu diesem Protein an.
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these data demonstrate that c-Maf is an indispensable yet constitutive transcription factor for IL-10 (zeige IL10 Proteine) gene expression in LPS (zeige TLR4 Proteine)-activated B cells
The control of cMaf expression at the translational level by mTOR (zeige FRAP1 Proteine) regulated the expression of inflammatory genes in response to lipopolysaccharide challenge.
results suggest that pathobiont-dependent inflammatory bowel disease is driven by microbiota-reactive T cells that have escaped this c-MAF-dependent mechanism of iTreg-TH17 homeostasis
c-Maf is a critical transcription factor regulating T-cell specialization in mice, essential for generation of both RORgammat(+) Tregs and T follicular regulatory cells, but not for adipose-resident Tregs. c-Maf is induced in Tregs by IL-6 (zeige IL6 Proteine) and TGF-beta (zeige TGFB1 Proteine).
interplay between MATalpha1, c-Myc (zeige MYC Proteine), and Maf proteins, and their deregulation during chronic cholestasis may facilitate cholangiocarcinoma oncogenesis
MafB (zeige MAFB Proteine) and c-Maf have different expression patterns in macrophages, suggesting differences in function.
HERC4 (zeige HERC4 Proteine) mediates c-Maf ubiquitination and delays growth of multiple myeloma.
Collectively, these studies show that FGF signaling up-regulates expression of alphaA-crystallin (zeige CRYAA Proteine) both directly and indirectly via up-regulation of c-Maf.
Tec (zeige NR4A3 Proteine) enhances c-Maf-dependent IL-4 (zeige IL4 Proteine) promoter activity. This effect of Tec (zeige NR4A3 Proteine) is counteracted by Ptpn22 (zeige PTPN22 Proteine), which physically interacts with and facilitates tyrosine dephosphorylation of c-Maf thereby attenuating its transcriptional activity.
endogenous small-Maf factors negatively regulate beta-cell function by competing for MafA (zeige MAFA Proteine) binding, and thus, the inhibition of small-Maf activity can improve beta-cell function
common variant , rs889472, of c-MAF is associated with gout susceptibility.
we identified two heterozygous rare variants in genes that are involved in early cataract development; the novel c.809C>A; p.(Ser270Tyr) in MAF and the c.168C>G; p.(Tyr56 *) variant in CRYGD (zeige CRYGD Proteine), previously reported as pathogenic
UBE2O (zeige UBE2O Proteine) mediates c-Maf polyubiquitination and degradation, induces MM cell apoptosis, and suppresses myeloma tumor growth, which provides a novel insight in understanding myelomagenesis and UBE2O (zeige UBE2O Proteine) biology.
The interaction between c-Maf and RORgammat, and Blimp-1 (zeige PRDM1 Proteine).
Polymorphisms rs9939609 (FTO (zeige FTO Proteine) gene) and rs1424233 (MAF gene) were genotyped using allelic discrimination assays in a prospective multicenter cohort study; these polymorphisms did not show associations with birth weight, BMI and Ponderal Index at discharge, and weight gain, neither testing for a dominant, additive nor for a recessive model.
this study shows that genes associated with MAF-binding enhancers are suppressed in macrophages isolated from rheumatoid-arthritis patients, revealing a disease-associated signature of IFN-gamma (zeige IFNG Proteine)-mediated repression
Our results argued that increased expression of sIL6R from myeloid cells and subsequent c-Maf induction were adverse events for counteracting tumor-specific Th1 (zeige TH1L Proteine) generation. Overall, this work provides a mechanistic rationale for sIL6R targeting to improve the efficacy of T-cell-mediated cancer immunotherapy
These results define the role of MAF and GSK3 in the resistance of t(14;16) multiple myeloma to proteasome inhibitors.
Epidermal differentiation gene regulatory networks are controlled by MAF and MAFB (zeige MAFB Proteine).
The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor. This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene.
v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)
, V-maf musculoaponeurotic fibrosarcoma oncogene homolog
, c-Maf long form
, proto-oncogene c-maf
, transcription factor Maf
, Avian musculoaponeurotic fibrosarcoma (MAF) protooncogene
, T lymphocyte c-maf long form
, c-maf proto-oncogene
, proto-oncogene c-Maf
, transcription factor Maf-2
, Proto-oncogene c-maf